1-tert-butyl 4-ethyl 4-[(1-trityl-1H-imidazol-4-yl)methyl]piperidine-1,4-dicarboxylate | 1192189-81-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-tert-butyl 4-ethyl 4-[(1-trityl-1H-imidazol-4-yl)methyl]piperidine-1,4-dicarboxylate
• 英文别名: 1-tert-butyl 4-ethyl 4-((1-trityl-1H-imidazol-4-yl)methyl)piperidine-1,4-dicarboxylate；1-O-tert-butyl 4-O-ethyl 4-[(1-tritylimidazol-4-yl)methyl]piperidine-1,4-dicarboxylate
• CAS: 1192189-81-3
• 化学式: C₃₆H₄₁N₃O₄
• 分子量: 579.739
• InChiKey: VLTMCFBUCPVEND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  43
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  73.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-tert-butyl 4-ethyl 4-[(1-trityl-1H-imidazol-4-yl)methyl]piperidine-1,4-dicarboxylate 在 盐酸 、 甲醇 、 水 、 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 、 lithium hydroxide 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲醇 、 醋酸异丙酯 为溶剂， 反应 3.08h， 生成 3-{4-[(1H-imidazol-4-yl)methyl]piperidine-4-carboxamido}phenyl N,N-dimethylcarbamate
  参考文献：
  名称：

  Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma

  摘要：

  The structure of LX7101, a dual LIM-kinase and ROCK inhibitor for the treatment of ocular hypertension and associated glaucoma, is disclosed. Previously reported LIM kinase inhibitors suffered from poor aqueous stability due to solvolysis of the central urea. Replacement of the urea with a hindered amide resulted in aqueous stable compounds, and addition of solubilizing groups resulted in a set of compounds with good properties for topical dosing in the eye and good efficacy in a mouse model of ocular hypertension. LX7101 was selected as a clinical candidate from this group based on superior efficacy in lowering intraocular pressure and a good safety profile. LX7101 completed IND enabling studies and was tested in a Phase 1 clinical trial in glaucoma patients, where it showed efficacy in lowering intraocular pressure.

  DOI：

  10.1021/ml500367g
• 作为产物：
  描述：

  4-(氯甲基)-1-(三苯基甲基)-1H-咪唑 、 N-Boc-4-哌啶甲酸乙酯 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 1.17h， 以51%的产率得到1-tert-butyl 4-ethyl 4-[(1-trityl-1H-imidazol-4-yl)methyl]piperidine-1,4-dicarboxylate
  参考文献：
  名称：

  LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE

  摘要：

  LIM激酶2的抑制剂已被披露，以及包含它们的药物组合物和它们的使用方法。特定化合物的化学式如下：

  公开号：

  US20090264450A1

文献信息

• LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
  申请人：Burgoon Hugh Alfred

  公开号：US20090264450A1

  公开（公告）日：2009-10-22

  Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions comprising them and methods of their use. Particular compounds are of the formula:

  LIM激酶2的抑制剂已被披露，以及包含它们的药物组合物和它们的使用方法。特定化合物的化学式如下：
• LIMK2 inhibitors, compositions comprising them, and methods of their use
  申请人：Lexicon Pharmaceuticals, Inc.

  公开号：US08193202B2

  公开（公告）日：2012-06-05

  Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions comprising them and methods of their use. Particular compounds are of the formula:

  本发明揭示了LIM激酶2的抑制剂，以及包含它们的制药组合物和它们的使用方法。特别的化合物的化学式如下：
• US8193202B2
  申请人：——

  公开号：US8193202B2

  公开（公告）日：2012-06-05
• US8450332B2
  申请人：——

  公开号：US8450332B2

  公开（公告）日：2013-05-28
• [EN] LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE<br/>[FR] INHIBITEURS DE LIMK2, COMPOSITIONS LES COMPRENANT ET LEURS PROCÉDÉS D'UTILISATION
  申请人：LEXICON PHARMACEUTICALS INC

  公开号：WO2009131940A1

  公开（公告）日：2009-10-29

  Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions comprising them and methods of their use. Particular compounds are of the formula (I).