(2-tritylsulfanylphenyl)-methanol | 947171-86-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (2-tritylsulfanylphenyl)-methanol
• 英文别名: (2-Tritylsulfanylphenyl)-methanol；(2-tritylsulfanylphenyl)methanol
• CAS: 947171-86-0
• 化学式: C₂₆H₂₂OS
• 分子量: 382.526
• InChiKey: HEYDXTWKMBKXLS-UHFFFAOYSA-N

物化性质

• 沸点：
  537.1±50.0 °C(Predicted)
• 密度：
  1.22±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2-tritylsulfanylphenyl)-methanol 在 pyridinium chlorochromate 作用下， 生成
  参考文献：
  名称：

  Peptide ligation assisted by an auxiliary attached to amidyl nitrogen

  摘要：

  New thiol-containing auxiliaries were developed for peptide ligation. They were placed at the amidyl N-atom in the second amino acid residue of a peptide fragment. With the new auxiliaries, peptide ligation could be conducted at non-Cys and non-Gly sites. Compared to other recently developed auxiliaries, an important feature of the present design was that the new auxiliaries were generally applicable and readily removable. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.01.108
• 作为产物：
  描述：

  methyl 2-(tritylthio)benzoate 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 (2-tritylsulfanylphenyl)-methanol
  参考文献：
  名称：

  Peptide ligation assisted by an auxiliary attached to amidyl nitrogen

  摘要：

  New thiol-containing auxiliaries were developed for peptide ligation. They were placed at the amidyl N-atom in the second amino acid residue of a peptide fragment. With the new auxiliaries, peptide ligation could be conducted at non-Cys and non-Gly sites. Compared to other recently developed auxiliaries, an important feature of the present design was that the new auxiliaries were generally applicable and readily removable. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.01.108

文献信息

• [EN] PYRIMIDOPYRIDAZINE DERIVATIVES USEFUL AS P38 MAPK INHIBITORS<br/>[FR] DÉRIVÉS DE PYRIMIDOPYRIDAZINE UTILES COMME INHIBITEURS DE LA P38 MAP KINASE
  申请人：PULMAGEN THERAPEUTICS INFLAMMA

  公开号：WO2010094955A1

  公开（公告）日：2010-08-26

  A compound formula (IA) or (IB), or a pharmaceutically acceptable thereof; wherein the substituents are defined as in the claims, and their use as P38 MAP kinase.

  一种化合物公式（IA）或（IB），或其制药可接受物；其中取代基如权利要求中所定义，并且它们的用途是P38 MAP激酶。
• PYRIMIDOPYRIDAZINE DERIVATIVES USEFUL AS P38 MAPK INHIBITORS
  申请人：Beswick Amanda

  公开号：US20120077809A1

  公开（公告）日：2012-03-29

  A compound formula (IA) or (IB), or a pharmaceutically acceptable thereof; wherein the substituents are defined as in the claims, and their use as P38 MAP kinase.

  一种化合物公式（IA）或（IB），或其药学上可接受的衍生物；其中取代基如权利要求中所定义，并且它们的用途是P38 MAP激酶。
• Pyrimidopyridazine derivatives useful as P38 MAPK inhibitors
  申请人：Beswick Amanda

  公开号：US08450314B2

  公开（公告）日：2013-05-28

  A compound formula (IA) or (IB), or a pharmaceutically acceptable thereof; wherein the substituents are defined as in the claims, and their use as P38 MAP kinase.

  一种化合物公式（IA）或（IB），或其药学上可接受的衍生物；其中取代基的定义如权利要求中所述，并且它们的用途是P38 MAP激酶。
• US8450314B2
  申请人：——

  公开号：US8450314B2

  公开（公告）日：2013-05-28
• Peptide ligation assisted by an auxiliary attached to amidyl nitrogen
  作者：Juan Li、Hong-Kui Cui、Lei Liu

  DOI：10.1016/j.tetlet.2010.01.108

  日期：2010.3

  New thiol-containing auxiliaries were developed for peptide ligation. They were placed at the amidyl N-atom in the second amino acid residue of a peptide fragment. With the new auxiliaries, peptide ligation could be conducted at non-Cys and non-Gly sites. Compared to other recently developed auxiliaries, an important feature of the present design was that the new auxiliaries were generally applicable and readily removable. (C) 2010 Elsevier Ltd. All rights reserved.