3-mercapto-6-furfuryl-1,2,4-triazin-5-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 3-mercapto-6-furfuryl-1,2,4-triazin-5-one
• 英文别名: 6-(furan-2-ylmethyl)-3-sulfanylidene-2H-1,2,4-triazin-5-one
• 化学式: C₈H₇N₃O₂S
• 分子量: 209.228
• InChiKey: AZNSSTGHNZIUTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  98.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-mercapto-6-furfuryl-1,2,4-triazin-5-one 、 碘甲烷 在 sodium ethanolate 作用下， 反应 0.5h， 以91%的产率得到6-(furan-2-ylmethyl)-3-methylsulfanyl-4H-1,2,4-triazin-5-one
  参考文献：
  名称：

  Khamaev, V. Kh.; Danilov, V. A.; Khannanov, R. N., Russian Journal of Organic Chemistry, 1994, vol. 30, # 5.2, p. 825 - 829

  摘要：

  DOI：
• 作为产物：
  描述：

  5-(furan-2-ylmethylene)thiazolidine-2,4-dione 、 氨基硫脲 在 氢氧化钾 作用下， 反应 3.0h， 以15%的产率得到3-mercapto-6-furfuryl-1,2,4-triazin-5-one
  参考文献：
  名称：

  Khamaev, V. Kh.; Danilov, V. A.; Khannanov, R. N., Russian Journal of Organic Chemistry, 1994, vol. 30, # 5.2, p. 825 - 829

  摘要：

  DOI：

文献信息

• Compositions and methods for stabilizing benzothiazole luciferin analogs
  申请人：PROMEGA CORPORATION

  公开号：US11136615B2

  公开（公告）日：2021-10-05

  Disclosed herein are compositions and methods for stabilizing a benzothiazole luciferin analog such as D-luciferin and 6-amino-D-luciferin. The compositions may include the benzothiazole luciferin analog, a thionucleobase compound of formula (I), and a liquid medium, in which the thionucleobase is present in an amount effective to stabilize the luminogenic composition against decomposition. The methods provided herein may stabilize the benzothiazole luciferin analog against decomposition by contacting the benzothiazole luciferin analog with an effective amount of the thionucleobase compound in the presence of a liquid medium. Also provided herein is a kit containing the composition.

  本文公开了稳定苯并噻唑荧光素类似物（如 D-荧光素和 6-氨基-D-荧光素）的组合物和方法。这些组合物可包括苯并噻唑荧光素类似物、式（I）的硫代核酸酯化合物和液体培养基，其中硫代核酸酯的含量可有效稳定发光组合物，防止其分解。本文提供的方法可通过在液体介质存在下使苯并噻唑荧光素类似物与有效量的硫代核酸酶化合物接触来稳定苯并噻唑荧光素类似物，防止其分解。本文还提供了一种含有该组合物的试剂盒。
• COMPOSITIONS AND METHODS FOR STABILIZING LUMINOGENIC SUBSTRATES
  申请人：Promega Corporation

  公开号：EP3146066B1

  公开（公告）日：2018-03-14
• COMPOSITIONS AND METHODS FOR STABILIZING BENZOTHIAZOLE LUCIFERIN ANALOGS
  申请人：Promega Corporation

  公开号：EP3661932B1

  公开（公告）日：2021-10-06
• US9676997B2
  申请人：——

  公开号：US9676997B2

  公开（公告）日：2017-06-13
• [EN] COMPOSITIONS AND METHODS FOR STABILIZING LUMINOGENIC SUBSTRATES<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE STABILISATION DE SUBSTRATS LUMINOGÈNES
  申请人：PROMEGA CORP

  公开号：WO2015179864A1

  公开（公告）日：2015-11-26

  Disclosed herein are compositions and methods for stabilizing a luminogenic substrate such as coelenterazine or a functional analog thereof. The functional analog may be furimazine. The composition may include the luminogenic substrate, a thionucleoside, and an organic solvent, in which the thionucleoside is present in an amount effective to stabilize the luminogenic composition against decomposition. The method provided herein stabilizes the luminogenic substrate against decomposition by contacting the luminogenic substrate with an effective amount of the thionucleoside in the presence of the organic solvent. Also provided herein is a kit containing the composition.