1-hydroxy-3,4,7,8-tetramethoxyxanthone | 54557-68-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1-hydroxy-3,4,7,8-tetramethoxyxanthone
• 英文别名: 8-hydroxy-1,2,5,6-tetramethoxy-xanthen-9-one；1-Hydroxy-3,4,7,8-tetramethoxy-xanthon；8-Hydroxy-1,2,5,6-tetramethoxyxanthen-9-one
• CAS: 54557-68-5
• 化学式: C₁₇H₁₆O₇
• 分子量: 332.31
• InChiKey: IVIHXSCDINRQJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  83.4
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  重氮甲烷 、 1,7-dihydroxy-3,4,8-trimethoxyxanthone 以 乙醚 为溶剂， 反应 48.0h， 以50 mg的产率得到1-hydroxy-3,4,7,8-tetramethoxyxanthone
  参考文献：
  名称：

  Pentaoxygenated xanthones from Bredemeyera floribunda

  摘要：

  A chloroform extract of the roots of Bredemeyera floribunda yielded two new pentaoxygenated xanthones, 1,7-dihydroxy-3,4,8-trimethoxyxanthone and 1,3,7-trihydroxy-4,8-dimethoxyxanthone, and the ethanol extract of the resulting marc yielded 1,3,6-trihydroxy-2,7-dimethoxyxanthone. Structure determination of these pentaoxygenated xanthones was accomplished by spectral analysis, mainly NMR, including normal and inverse detection techniques such as HETCOR and HMBC. Chemical derivatization and comparison to literature data were also used.

  DOI：

  10.1016/0031-9422(95)00103-e

文献信息

• Xanthone Glycoside Constituents of <i>Swertia kouitchensis</i> with α-Glucosidase Inhibitory Activity
  作者：Luo-Sheng Wan、Qiu-Xia Min、Yong-Long Wang、Yao-Dong Yue、Jia-Chun Chen

  DOI：10.1021/np400082g

  日期：2013.7.26

  Ten new xanthone glycosides, kouitchensides A–J (1–10), and 11 known analogues were isolated from an n-butanol fraction of Swertia kouitchensis. The structures of these glycosides were determined on the basis of extensive spectroscopic data interpretation and comparison with data reported in the literature. In an in vitro test, compounds 2, 4, 5, 6, 11, 12, and 13 (IC50 values in the range 126 to 451

  从Swertia kouitchensis的正丁醇级分中分离出十个新的黄酮苷，kouitchensides A–J（1 – 10）和11种已知的类似物。这些糖苷的结构是在广泛的光谱数据解释和与文献报道的数据比较的基础上确定的。在体外测试中，化合物2，4，5，6，11，12，和13（IC 50个范围为126至451μM值）显示对α葡糖苷酶活性更有效的抑制效果比阳性对照，阿卡波糖（ IC 50 值627μM）。