7-nitro-N-(thiophen-2-ylmethyl)-2,1,3-benzoxadiazole-4-amine | 869771-26-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶二唑类
• 英文名称: 7-nitro-N-(thiophen-2-ylmethyl)-2,1,3-benzoxadiazole-4-amine
• 英文别名: N4-(2-thienylmethyl)-7-nitro-2,1,3-benzoxadiazol-4-amine；4-nitro-N-(thiophen-2-ylmethyl)-2,1,3-benzoxadiazol-7-amine
• CAS: 869771-26-6
• 化学式: C₁₁H₈N₄O₃S
• 分子量: 276.276
• InChiKey: QJQJHCJXIXFXJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  125
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  7-nitro-N-(thiophen-2-ylmethyl)-2,1,3-benzoxadiazole-4-amine 、 氯甲酸烯丙酯 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 12.08h， 以89%的产率得到7-nitro-2,1,3-benzoxadiazole-4-allyl-N-(thiophen-2-ylmethyl)carbamate
  参考文献：
  名称：

  Highly selective and sensitive fluorescence chemosensor for the detection of palladium species based on Tsuji–Trost reaction

  摘要：

  A new chemosensor 7-nitro-2,1,3-benzoxadiazole-4-allyl-N-(thiophen-2-ylmethyl)carbamate (NBDTC) was synthesized and utilized for palladium detection based on the Tsuji-Trost reaction. NBDTC displayed specific and ratiometric fluorescent responses toward palladium species. The chemosensor showed more than 50-fold enhancement in fluorescence intensity with the presence of PEG400 and palladium because NBDTC can be transformed to NBDT under palladium-catalyzing Tsuji-Trost reaction. NBDTC displayed high selectivity and sensitivity for palladium species with the detection limit of 1.13 x 10(-9) M. (C) 2015 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2015.03.130
• 作为产物：
  描述：

  2-噻吩甲胺 、 4-氯-7-硝基苯并-2-氧杂-1,3-二唑 以 乙腈 为溶剂， 反应 0.5h， 以52%的产率得到7-nitro-N-(thiophen-2-ylmethyl)-2,1,3-benzoxadiazole-4-amine
  参考文献：
  名称：

  Highly selective and sensitive fluorescence chemosensor for the detection of palladium species based on Tsuji–Trost reaction

  摘要：

  A new chemosensor 7-nitro-2,1,3-benzoxadiazole-4-allyl-N-(thiophen-2-ylmethyl)carbamate (NBDTC) was synthesized and utilized for palladium detection based on the Tsuji-Trost reaction. NBDTC displayed specific and ratiometric fluorescent responses toward palladium species. The chemosensor showed more than 50-fold enhancement in fluorescence intensity with the presence of PEG400 and palladium because NBDTC can be transformed to NBDT under palladium-catalyzing Tsuji-Trost reaction. NBDTC displayed high selectivity and sensitivity for palladium species with the detection limit of 1.13 x 10(-9) M. (C) 2015 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2015.03.130

文献信息

• SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND HEMATOLOGICAL DISEASES
  申请人：Thede Kai

  公开号：US20100305085A1

  公开（公告）日：2010-12-02

  The invention relates to dihydropyrazolon-derivatives of formula (I), to methods for their production, to their use for treating and/or for preventing diseases and their use for producing medicaments for treating and/or for preventing diseases, in particular cardiovascular and haematological diseases, kidney diseases and for promoting the healing of wounds.

  这项发明涉及式(I)的二氢吡唑酮衍生物，以及它们的生产方法，它们用于治疗和/或预防疾病以及用于生产治疗和/或预防疾病的药物，特别是心血管和血液疾病、肾脏疾病以及促进伤口愈合的用途。
• 2,1,3-BENZOXADIAZOL DERIVATIVES FOR THE INHIBITION OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION
  申请人：Pike Pharma GmbH

  公开号：EP2427442A1

  公开（公告）日：2012-03-14
• US8389520B2
  申请人：——

  公开号：US8389520B2

  公开（公告）日：2013-03-05
• US8653111B2
  申请人：——

  公开号：US8653111B2

  公开（公告）日：2014-02-18
• US8987261B2
  申请人：——

  公开号：US8987261B2

  公开（公告）日：2015-03-24