丹磺酰-苯胺 | 34532-47-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 丹磺酰-苯胺
• 英文名称: 5-(dimethylamino)naphthalene-1-sulfonic acid phenylamide
• 英文别名: 5-Dimethylamino-N-phenylnaphtalin-1-sulfonamid；5-dimethylamino-naphthalene-1-sulfonic acid anilide；5-Dimethylamino-naphthalin-1-sulfonsaeure-anilid；5-Dimethylaminonaphthalin-1-sulfonamido)benzol；(5-Dimethylaminonaphthalene-1-sulfonamido) benzene；5-(dimethylamino)-N-phenylnaphthalene-1-sulfonamide
• CAS: 34532-47-3
• 化学式: C₁₈H₁₈N₂O₂S
• 分子量: 326.419
• InChiKey: UCUULWNDKYKHTN-UHFFFAOYSA-N

物化性质

• 熔点：
  141.6-141.8 °C
• 沸点：
  494.2±37.0 °C(Predicted)
• 密度：
  1.302±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿、乙酸乙酯

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丹酰氯 、 苯胺 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以86%的产率得到丹磺酰-苯胺
  参考文献：
  名称：

  使用基于芳基硼酸与汞物种的置换反应的荧光探针，快速灵敏地检测无机汞和甲基汞。

  摘要：

  基于芳基硼酸与汞物种的置换反应，我们提出了基于反应的Hg2 +和CH3Hg +荧光探针（1）。图1显示了Hg2 +和CH3Hg +的有希望的传感特性，例如高选择性和灵敏度，开启响应，对Hg2 +的快速响应（<2分钟）和CH3Hg +（<5分钟），低检测限以及在纯水溶液中的操作。

  DOI：

  10.1039/c9cc09240d

文献信息

• 5-(Dimethylamino)-N-(4-ethynylphenyl)-1-naphthalenesulfonamide as a novel bifunctional antitumor agent and two-photon induced bio-imaging probe
  作者：C.-H. Chui、Q. Wang、W.-C. Chow、M. C.-W. Yuen、K.-L. Wong、W.-M. Kwok、G. Y.-M. Cheng、R. S.-M. Wong、S.-W. Tong、K.-W. Chan、F.-Y. Lau、P. B.-S. Lai、K.-H. Lam、E. Fabbri、X.-M. Tao、R. Gambari、W.-Y. Wong

  DOI：10.1039/b926908h

  日期：——

  A novel compound, (5-(dimethylamino)-N-(4-ethynylphenyl)-1-naphthalenesulfonamide), was prepared and characterized; it shows dual functional roles as an effective antitumor and a two-photon induced bio-imaging agent.

  一种新化合物（5-(二甲氨基)-N-(4-乙炔基苯基)-1-萘磺酰胺）被制备并表征；它表现出作为有效的抗肿瘤剂和双光子诱导生物成像剂的双重功能。
• Fluorescence modulation in anion sensing by introducing intramolecular H-bonding interactions in host–guest adducts
  作者：Yun Mi Chung、Balamurali Raman、Dae-Sik Kim、Kyo Han Ahn

  DOI：10.1039/b510795d

  日期：——

  Fluorescence signaling in anion binding is modulated from quenching to enhancement by intramolecular H-bonding stabilization of anion–ionophore adducts; the intramolecular H-bonding is suggested to suppress the quenching processes otherwise possible and increase the conformational rigidity of the anionic adducts, leading to fluorescence enhancement in a selective fashion towards cyanide ion, among the various anions examined.

  阴离子结合中的荧光信号通过分子内氢键稳定阴离子-离子载体加合物，从淬灭调节为增强；分子内氢键被认为抑制了可能发生的淬灭过程，并增加了阴离子加合物的构象刚性，从而在各类阴离子中选择性地增强了对氰离子的荧光增强效果。
• Kallmayer, H.-J.; Schwarz, P., Pharmazie, 1989, vol. 44, # 2, p. 119 - 122
  作者：Kallmayer, H.-J.、Schwarz, P.

  DOI：——

  日期：——
• Fluorescent Sensing and Selective Pb(II) Extraction by a Dansylamide Ion-Exchanger
  作者：Konstantinos Kavallieratos、Jay M. Rosenberg、Wei-Zhong Chen、Tong Ren

  DOI：10.1021/ja050296e

  日期：2005.5.1

  The (bis)dansylated sulfonamide 1,2-C6H4(NHSO2C10H6-5-N(CH3)2)2 (1) extracted Pb(II) selectively from water into 1,2-dichloroethane via an ion-exchange mechanism and showed fluorescence quenching upon Pb(II) extraction. The distribution ratios for metal extraction (determined by ICP-MS) for Pb(II) were 133-1410 times higher than those for other metal cations [Co(II), Ni(II), Cu(II), Zn(II), and Cd(II)] under identical conditions. Fluorescence quenching was observed upon Pb(II) extraction, which was dependent on Pb(II) concentration. The monodansylated control, C6H5NHSO2C10H6-5-N(CH3)2 (2), showed neither extraction nor quenching, indicating that the fluorescence effects are a direct result of Pb coordination to 1. The observed selectivity for Pb(II) is ascribed to the formation of a low-coordinate binary Pb(II)-Sulfonamido complex in the organic phase.
• KALLMAYER, H. -J.;SCHWARZ, P., PHARMAZIE, 44,(1989) N, C. 119-123
  作者：KALLMAYER, H. -J.、SCHWARZ, P.

  DOI：——

  日期：——