25,26,27,28-tetrapentoxy-11-N,23-N-ditritylpentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(24),3,5,7(28),9,11,13(27),15(26),16,18,21(25),22-dodecaene-5,11,17,23-tetramine | 935739-56-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 25,26,27,28-tetrapentoxy-11-N,23-N-ditritylpentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(24),3,5,7(28),9,11,13(27),15(26),16,18,21(25),22-dodecaene-5,11,17,23-tetramine
• CAS: 935739-56-3
• 化学式: C₈₆H₉₆N₄O₄
• 分子量: 1249.73
• InChiKey: KFGYOKKIHTVZAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  22.7
• 重原子数：
  94
• 可旋转键数：
  30
• 环数：
  11.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  25,26,27,28-tetrapentoxy-11-N,23-N-ditritylpentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(24),3,5,7(28),9,11,13(27),15(26),16,18,21(25),22-dodecaene-5,11,17,23-tetramine 、 乙酸酐 在 三乙胺 作用下， 生成 N-[17-(1-hydroxyethylideneamino)-25,26,27,28-tetrapentoxy-11,23-bis(tritylamino)-5-pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(24),3,5,7(28),9,11,13(27),15(26),16,18,21(25),22-dodecaenyl]ethanimidic acid
  参考文献：
  名称：

  First Protection of a Wide-Rim Tetraamino Calix[4]arene in Opposite Positions

  摘要：

  The importance of tetraamino calix[4]arenes as starting materials is distinctly increased by the first versatile protective group for opposite amino functions. Reaction with trityl chloride leads to the 1,3-dialkylated derivative easily isolated in 34% yield; after a first acylation of the remaining amino groups, the trityl residues can be removed by TFA to introduce a second acyl group.

  DOI：

  10.1021/ol062943s
• 作为产物：
  描述：

  三苯基甲基溴 、 5,11,17,23-tetraamino-25,26,27,28-tetrapentoxy-calix<4>arene 在 三乙胺 作用下， 以 氯仿 为溶剂， 生成 、 25,26,27,28-tetrapentoxy-11-N,23-N-ditritylpentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(24),3,5,7(28),9,11,13(27),15(26),16,18,21(25),22-dodecaene-5,11,17,23-tetramine 、 、
  参考文献：
  名称：

  First Protection of a Wide-Rim Tetraamino Calix[4]arene in Opposite Positions

  摘要：

  The importance of tetraamino calix[4]arenes as starting materials is distinctly increased by the first versatile protective group for opposite amino functions. Reaction with trityl chloride leads to the 1,3-dialkylated derivative easily isolated in 34% yield; after a first acylation of the remaining amino groups, the trityl residues can be removed by TFA to introduce a second acyl group.

  DOI：

  10.1021/ol062943s

文献信息

• Stepwise Synthesis and Selective Dimerisation of Bis- and Trisloop Tetra-urea Calix[4]arenes
  作者：Yuliya Rudzevich、Yudong Cao、Valentyn Rudzevich、Volker Böhmer

  DOI：10.1002/chem.200701694

  日期：2008.4.7

  derivatives. A tetra-urea calix[4]arene of the AABB type, where A stands for a bisalkenyl- and B for a monoalkenyl-substituted urea unit, was used as precursor for the three loops. It was easily synthesised from a tetraamino calix[4]arene in which two adjacent amino groups were Boc-protected. The ABCB-type precursor for the two adjacent loops was prepared through protection of two opposite amino functions with

  使用四甲苯脲杯[4]芳烃作为模板，通过分子内烯烃复分解，被四个单或双烯基残基取代的四脲杯[4]芳烃已转化为双环或四环化合物。现在已使用相同的策略来合成具有相邻环的三环化合物和双环化合物，从而完成了一系列含环的四脲衍生物。使用AABB型的四脲杯[4]芳烃，其中A代表双烯基-，B代表单烯基取代的脲单元，被用作三个环的前体。它很容易从四氨基杯[4]芳烃中合成，其中两个相邻的氨基被Boc保护。通过用三苯甲基保护两个相对的氨基官能团，制备了两个相邻环的ABCB型前体。
• First Protection of a Wide-Rim Tetraamino Calix[4]arene in Opposite Positions
  作者：Yuliya Rudzevich、Valentyn Rudzevich、Dieter Schollmeyer、Volker Böhmer

  DOI：10.1021/ol062943s

  日期：2007.3.1

  The importance of tetraamino calix[4]arenes as starting materials is distinctly increased by the first versatile protective group for opposite amino functions. Reaction with trityl chloride leads to the 1,3-dialkylated derivative easily isolated in 34% yield; after a first acylation of the remaining amino groups, the trityl residues can be removed by TFA to introduce a second acyl group.