3-propylvalerolactam | 90275-41-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-propylvalerolactam
• 英文别名: 3-propylpiperidin-2-one；tetrahydro-3-propylpyridin-2(1H)-one；3-propyl-2-piperidinone；3-Propyl-piperidin-2-on；α-propylvalerolactam
• CAS: 90275-41-5
• 化学式: C₈H₁₅NO
• 分子量: 141.213
• InChiKey: ADKCQAYBVJSZMZ-UHFFFAOYSA-N

物化性质

• 熔点：
  60-63 °C
• 沸点：
  280.1±9.0 °C(Predicted)
• 密度：
  0.922±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-propylvalerolactam 在 盐酸 作用下， 以 甲苯 为溶剂， 以1.9 g (11.9 mmol, 84%)的产率得到rac-5-amino-2-propylpentanoic acid monohydrochloride
  参考文献：
  名称：

  4'-methyl substituted fluorescein derivatives

  摘要：

  本发明涉及一种新型的用于荧光偏振免疫分析的示踪化合物。这种新型的4'-甲基荧光素衍生物通过环状连接剂与配体结合。

  公开号：

  US05986094A1
• 作为产物：
  描述：

  2-propyl-5-amino-pentanoic acid 生成 3-propylvalerolactam
  参考文献：
  名称：

  Aschan, Chemische Berichte, 1890, vol. 23, p. 3696

  摘要：

  DOI：

文献信息

• Photochemical Rearrangement of <i>N</i>-Chlorolactams: A Route to <i>N</i>-Heterocycles through Concerted Ring Contraction
  作者：Dana K. Winter、Alexandre Drouin、Jean Lessard、Claude Spino

  DOI：10.1021/jo100181h

  日期：2010.4.16

  We report a novel ring contraction allowing the direct conversion of N-chlorolactams to their corresponding ring-contraction N-heterocycles upon photolysis. Results show that the rearrangement occurs with a variety of N-chlorolactams and that the greater the substitution at the migrating carbon, the greater the yield of product. Importantly, stereochemistry at the migrating carbon is conserved in the

  我们报道了一种新颖的环收缩，其允许N-氯内酰胺在光解后直接转化为其相应的环收缩N-杂环。结果表明，各种N-氯内酰胺都发生了重排，并且在迁移的碳上取代量越大，产物的收率就越高。重要的是，产物中保留了迁移碳处的立体化学。分离出重排产物，其为氨基甲酸甲酯，收率从17％到58％不等，主要副产物为可回收的母体内酰胺。
• Concise syntheses of substituted indolizidine alkaloids via cyclization based on α-sulfinyl carbanions: preparation of (±)-indolizidines 167B and 209D, their epimers, and (±)-tashiromine
  作者：Manat Pohmakotr、Saisuree Prateeptongkum、Soontorn Chooprayoon、Patoomratana Tuchinda、Vichai Reutrakul

  DOI：10.1016/j.tet.2008.01.008

  日期：2008.3

  (±)-Indolizidines 167B and 209D, their epimers and (±)-tashiromine have been successfully synthesized, starting from simple γ- or α-lactams. The strategy involves the cyclization of α-sulfinyl carbanion onto the carbonyl group of the lactam ring as the key step, leading to the indolizidines containing the phenylsulfinyl group, which are used as precursors for the preparation of the title compounds

  从简单的γ-或α-内酰胺开始，已经成功地合成了（±）-吲哚唑烷167B和209D，它们的差向异构体和（±）-tashiromine。该策略涉及将α-亚磺酰基碳负环到内酰胺环的羰基上的环化作为关键步骤，从而导致含有苯基亚磺酰基的吲哚并咪唑用作制备标题化合物的前体。
• Fluorescent polarization immunoassay utilizing substituted
  申请人：Abbott Laboratories

  公开号：US04593089A1

  公开（公告）日：1986-06-03

  This disclosure relates to a method and reagents for determining ligands in biological fluids such as serum, plasma, spinal fluid, amnionic fluid and urine. In particular, this disclosure relates to a fluorescent polarization immunoassay procedure and to a novel class of tracer compounds employed as reagents in such procedures. The procedure disclosed combines the specificity of an immunoassay with the speed and convenience of fluorescent polarization techniques to provide a means for determining the amount of a specific ligand present in a sample.

  这项披露涉及一种用于确定生物体液中配体的方法和试剂，如血清、血浆、脑脊液、羊水和尿液。具体而言，这项披露涉及一种荧光极化免疫分析程序，以及一种作为此类程序中试剂的新型示踪化合物类。所披露的程序结合了免疫分析的特异性和荧光极化技术的速度和便利性，提供了一种确定样品中特定配体量的方法。
• Lactam and thiolactam derivatives as anesthetic and conscious sedation agents
  申请人：——

  公开号：US20030078283A1

  公开（公告）日：2003-04-24

  This invention relates to lactam and thiolactam derivatives having useful anesthetic and conscious sedation activity. Particularly useful compounds include the diethyl lactams such as 3,3-diethyl-2-pyrrolidinone. Methods for using these compounds and pharmaceutical compositions containing these compounds are provided.

  本发明涉及具有有用的麻醉和意识镇静活性的内酰胺和硫内酰胺衍生物。特别有用的化合物包括二乙基内酰胺，例如3,3-二乙基-2-吡咯酮。提供了使用这些化合物的方法和含有这些化合物的制药组合物。
• Triazinylaminofluoresceins
  申请人：Abbott Laboratories

  公开号：US05097097A1

  公开（公告）日：1992-03-17

  This disclosure relates to a method and reagents for determining ligands in biological fluids such as serum, plasma, spinal fluid, amnionic fluid and urine. In particular, this disclosure relates to a fluorescent polarization immunoassay procedure and to a novel class of tracer compounds employed as reagents in such procedures. The procedure disclosed combines the specificity of an immunoassay with the speed and convenience of fluorescent polarization techniques to provide a means for determining the amount of a specific ligand present in a sample.

  本公开涉及一种用于确定生物液体（如血清、血浆、脊髓液、羊水和尿液）中配体的方法和试剂。具体而言，本公开涉及一种荧光偏振免疫测定程序，以及用作这种程序中试剂的一类新型示踪剂化合物。所披露的程序将免疫测定的特异性与荧光偏振技术的速度和便利性相结合，以提供一种确定样品中特定配体数量的手段。