2-(Hexadecylsulfonyl)ethanol | 24475-69-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: 2-(Hexadecylsulfonyl)ethanol
• 英文别名: 2-hexadecylsulfonylethanol
• CAS: 24475-69-2
• 化学式: C₁₈H₃₈O₃S
• 分子量: 334.564
• InChiKey: OAOWTDYTNKQXBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  22
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(Hexadecylsulfonyl)ethanol 、 对硝基苯基氯甲酸酯 以 吡啶 为溶剂， 反应 5.0h， 以67%的产率得到
  参考文献：
  名称：

  On the use of hydrophobic probes in the chromatographic purification of solid-phase-synthesized peptides

  摘要：

  本文介绍了一种反相色谱纯化固相合成肽的策略，并通过合成 23 个聚合物的模型肽进行了说明；通过在树脂结合肽上附着疏水探针，可以将目标肽与终止副产物区分开来。

  DOI：

  10.1039/c39950000779
• 作为产物：
  描述：

  2-(hexadecylthio)ethanol 在 sodium tungstate 、 双氧水 作用下， 以 溶剂黄146 为溶剂， 反应 5.0h， 以78%的产率得到2-(Hexadecylsulfonyl)ethanol
  参考文献：
  名称：

  On the use of hydrophobic probes in the chromatographic purification of solid-phase-synthesized peptides

  摘要：

  本文介绍了一种反相色谱纯化固相合成肽的策略，并通过合成 23 个聚合物的模型肽进行了说明；通过在树脂结合肽上附着疏水探针，可以将目标肽与终止副产物区分开来。

  DOI：

  10.1039/c39950000779

文献信息

• Novel Biochip Substrate, Preparation Method and Application Thereof
  申请人：DALIAN UNIVERSITY OF TECHNOLOGY

  公开号：US20210011013A1

  公开（公告）日：2021-01-14

  The present disclosure discloses a novel biochip substrate, a preparation method and an application thereof. The surface of the novel biochip substrate contains active vinyl sulfone groups. The preparation method involves a one-step reaction of a compound containing vinyl sulfone groups on both ends with a silicon-hydroxyl group on the surface of a silicon-based biochip substrate material under catalytic conditions, to prepare the biochip substrate. The application immobilizes biomacromolecules by conducting Michael addition of amino or sulfydryl group in biomacromolecules and the vinyl sulfone group on the surface of the biochip substrate, realizing biological functionalization thereof. The biochip substrate has high-density active vinyl sulfone groups, which can be used for immobilization of various biomolecules with mild fixation conditions and simple operation. The preparation method does not require complex pretreatment processes, and has high operability and reproducibility, low cost, mild reaction conditions, simple operation, and environmentally friendly, which is a broad-spectrum biochip substrate with great potential.
• US4225449A
  申请人：——

  公开号：US4225449A

  公开（公告）日：1980-09-30
• On the use of hydrophobic probes in the chromatographic purification of solid-phase-synthesized peptides
  作者：Carlos García-Echeverría

  DOI：10.1039/c39950000779

  日期：——

  A strategy for the reversed-phase chromatographic purification of solid-phase-synthesized peptides is described and illustrated by the synthesis of a 23-mer model peptide; the target peptide is distinguished from terminated by-products by the attachment of a hydrophobic probe to the resin-bound peptide.

  本文介绍了一种反相色谱纯化固相合成肽的策略，并通过合成 23 个聚合物的模型肽进行了说明；通过在树脂结合肽上附着疏水探针，可以将目标肽与终止副产物区分开来。