[1-(2-hydroxyethyl)-1-Me-piperidinium] iodide | 67889-35-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: [1-(2-hydroxyethyl)-1-Me-piperidinium] iodide
• 英文别名: 1-(2-hydroxy-ethyl)-1-methyl-piperidinium; iodide；1-(2-Hydroxy-aethyl)-1-methyl-piperidinium; Jodid；2-(1-Methylpiperidin-1-ium-1-yl)ethanol;iodide
• CAS: 67889-35-4
• 化学式: C₈H₁₈NO*I
• 分子量: 271.142
• InChiKey: GCZKCOBZLKNNIR-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.39
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [1-(2-hydroxyethyl)-1-Me-piperidinium] iodide 在 Dowex 550A 作用下， 以 甲醇 为溶剂， 生成 2-(1-Methylpiperidin-1-ium-1-yl)ethanol;hydroxide
  参考文献：
  名称：

  Tetraphenylboroxinate(1-) salts of monoborate cations: Synthesis and single-crystal X-ray structures of [Ph2B{OCH2CH2N(Me)(CH2)n}2][Ph4B3O3] (n=4, 5)

  摘要：

  The salts, [Ph(2)B{OCH(2)CH(2)N(Me)(CH(2))(n)}(2)][Ph(4)B(3)O(3)](n = 4,5), were prepared in moderate yields in MeOH solution from reaction of Ph(2)BOBPh(2) with [N(CH(2))n(Me)(CH(2)CH(2)OH)][OH] and PhB(OH)(2) in a 1:2:4 ratio. The reactions also lead to Ph(3)B(3)O(3). Both salts were characterized by NMR ((1)H, (13)C, (11)B) IR, and single-crystal XRD studies. The salts are comprised of cationic monoborates (zwitterionic, 2N(+) and 1B(-)) and tetraphenylboroxinate anions. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2009.09.026
• 作为产物：
  描述：

  N-羟乙基哌啶 、 碘甲烷 以 乙腈 为溶剂， 以90 %的产率得到[1-(2-hydroxyethyl)-1-Me-piperidinium] iodide
  参考文献：
  名称：

  ECHINOCANDIN ANALOGUES AND PREPARATION METHOD THEREFOR

  摘要：

  本发明涉及一种棘白菌素衍生物及其制备方法。所述化合物可用于预防或治疗真菌感染，或用于预防、稳定或抑制真菌生长或杀灭真菌。示例性化合物由式I表示，其中R1、R2、R3和G组的定义如说明中所述。

  公开号：

  EP4063381A1

文献信息

• PROCESS FOR PRODUCING ETHYLENE GLYCOL CATALYZED BY IONIC LIQUID
  申请人：Zhang Suojiang

  公开号：US20130072727A1

  公开（公告）日：2013-03-21

  Disclosed is a process for producing ethylene glycol catalyzed by an ionic liquid, characterized in that the process includes the following three steps: (a) a carbonylation step of ethylene oxide and CO 2 catalyzed by an ionic liquid composite catalyst comprising a hydroxyl functionalized ionic liquid and an alkali metal salt under an aqueous condition to produce ethylene carbonate and ethylene glycol; (b) a hydrolysis step of reacting the reaction solution containing ethylene carbonate and the ionic liquid composite catalyst obtained in step (a) with water to produce ethylene glycol; (c) a purification step of dehydrating and refining ethylene glycol from the aqueous solution containing ethylene glycol and the catalyst produced in step (b). The present process has the following advantages: the catalyst has high activity, high suitability, and good stability, the reaction condition is wild, the conversion of ethylene oxide is high, the selectivity of ethylene glycol is high, and the process is simple.

  揭示了一种由离子液体催化生产乙二醇的过程，其特征在于该过程包括以下三个步骤：(a) 由含有羟基官能化离子液体和碱金属盐的离子液体复合催化剂在水相条件下催化乙烯氧化物和CO2的羰基化步骤，以产生碳酸乙烯酯和乙二醇；(b) 将步骤(a)中获得的含有碳酸乙烯和离子液体复合催化剂的反应溶液与水反应以产生乙二醇的水解步骤；(c) 从含有乙二醇和步骤(b)中产生的催化剂的水溶液中脱水和精制乙二醇的纯化步骤。该过程具有以下优点：催化剂活性高、适用性强、稳定性好，反应条件宽松，乙烯氧化物转化率高，乙二醇选择性高，过程简单。
• ECHINOCANDIN ANALOGUES AND PREPARATION METHOD THEREFOR
  申请人：Shanghai Senhui Medicine Co., Ltd.

  公开号：EP4063381A1

  公开（公告）日：2022-09-28

  The present invention relates to an echinocandin analogue and a preparation method therefor. The compound can be used for preventing or treating fungal infection, or for preventing, stabilizing or inhibiting fungal growth or killing fungi. An exemplary compound is represented by formula I, wherein the definitions of R1, R2, R3 and G groups are as described in the description.

  本发明涉及一种棘白菌素衍生物及其制备方法。所述化合物可用于预防或治疗真菌感染，或用于预防、稳定或抑制真菌生长或杀灭真菌。示例性化合物由式I表示，其中R1、R2、R3和G组的定义如说明中所述。
• v. Braun; Anton; Weissbach, Chemische Berichte, 1930, vol. 63, p. 2847,2861
  作者：v. Braun、Anton、Weissbach

  DOI：——

  日期：——
• Hazard et al., Therapie, 1954, vol. 9, p. 324,328
  作者：Hazard et al.

  DOI：——

  日期：——
• US8658842B2
  申请人：——

  公开号：US8658842B2

  公开（公告）日：2014-02-25