(2,3-dibromo-propyl)-urea | 54377-64-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: (2,3-dibromo-propyl)-urea
• 英文别名: (2,3-Dibrom-propyl)-harnstoff；N-(β.γ-Dibrom-propyl)-harnstoff；beta,gamma-Dibromopropylurea；2,3-dibromopropylurea
• CAS: 54377-64-9
• 化学式: C₄H₈Br₂N₂O
• 分子量: 259.928
• InChiKey: DWZVRVQLOMGRPV-UHFFFAOYSA-N

物化性质

• 沸点：
  298.2±40.0 °C(Predicted)
• 密度：
  1.985±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (2,3-dibromo-propyl)-urea 在 甲醇 、 sodium hydrogensulfide 、 硫化氢 作用下， 50.0~60.0 ℃ 、509.9 kPa 条件下， 生成 (2,3-dimercapto-propyl)-urea
  参考文献：
  名称：

  Pavlic; Lazier; Signaigo, Journal of Organic Chemistry, 1949, vol. 14, p. 61

  摘要：

  DOI：
• 作为产物：
  描述：

  烯丙基脲 在 水 、 溴 作用下， 生成 (2,3-dibromo-propyl)-urea
  参考文献：
  名称：

  Andreasch, Monatshefte fur Chemie, 1884, vol. 5, p. 45

  摘要：

  DOI：

文献信息

• Endogenous Anticholinergic Substances May Exist During Acute Illness in Elderly Medical Patients
  作者：J. M. Flacker、J. Y. Wei

  DOI：10.1093/gerona/56.6.m353

  日期：2001.6.1

  Background. The purpose of this study was to determine if serum anticholinergic activity (SACA) arises from endogenous substances produced during illness.Methods. Elderly medical inpatients (N = 612) were screened for anticholinergic medication use in the week prior to the study by interviews of subjects and proxies and review of emergency room, hospital, and nursing home medication administration records. Of 24 subjects without a recent anticholinergic medication history, 15 were recruited and 10 completed the study. Serum samples were obtained on Day 2 of hospital admission. SAGA was measured using a radionuclide displacement assay. Medications taken by subjects were assayed for central muscarinic receptor binding at therapeutic concentrations.Results. Eight of the ten subjects had SAGA detectable in the serum. No medication used by these subjects had anticholinergic activity at usual therapeutic concentrations.Conclusions. Endogenous anticholinergic substances may exist during acute illness. Characterization of such substances may increase the depth of our understanding of delirium and lead to useful intervention strategies.
• Diels, Justus Liebigs Annalen der Chemie, 1923, vol. 432, p. 125
  作者：Diels

  DOI：——

  日期：——
• DE265726
  申请人：——

  公开号：——

  公开（公告）日：——
• Rundqvist, Archiv der Pharmazie, 1898, vol. 236, p. 465
  作者：Rundqvist

  DOI：——

  日期：——
• Paal; Heupel, Chemische Berichte, 1891, vol. 24, p. 3045
  作者：Paal、Heupel

  DOI：——

  日期：——