N-<4-(1,1-Dimethylethyl)phenylmethyl>-α,N-dimethyl-1-naphthalinmethanamin

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-<4-(1,1-Dimethylethyl)phenylmethyl>-α,N-dimethyl-1-naphthalinmethanamin
• 英文别名: N-(4-tert-butylbenzyl)-N-methyl-1-(naphthalen-1-yl)ethanamine；N-4-tert-Butylbenzyl-N-methyl-1-(1-naphthyl)ethylamine；N-[(4-tert-butylphenyl)methyl]-N-methyl-1-naphthalen-1-ylethanamine
• 化学式: C₂₄H₂₉N
• 分子量: 331.501
• InChiKey: MBFIPZYGAXBFHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (S)-N-methyl-N-1-(1-naphthyl)ethyl amine 以74%的产率得到
  参考文献：
  名称：

  Stanetty Peter, Wallner Herbert, Arch. Pharm., 326 (1993) N 6, S 341- 350

  摘要：

  DOI：

文献信息

• Amine derivatives and fungicides containing the same
  申请人：Kaken Pharmaceutical Co., Ltd.

  公开号：US05021458A1

  公开（公告）日：1991-06-04

  Amine derivatives having the general formula (I): ##STR1## wherein X is selected from the group consisting of ##STR2## wherein Q is oxygen, sulfur or nitrogen atom, and ##STR3## wherein Q is as above; Y is selected from the group consisting of ##STR4## R.sup.1 is hydrogen atom or an alkyl group; R.sup.2 is hydrogen atom or an alkyl group; R.sup.3 is hydrogen atom, a halogen atom or an alkyl group; R.sup.4 is hydrogen atom, an alkyl group, a cycloalkyl group, a halogenated alkyl group or a halogen atom; R.sup.5 is hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, nitro group or hydroxy group; R.sup.5 is attached to an arbitrary position of X, and R.sup.3 or R.sup.4 is attached to an arbitrary position of Y. The amine derivatives (I) are useful as fungicides.

  具有通式(I)的胺衍生物：##STR1##其中X从以下组中选择：##STR2##其中Q是氧、硫或氮原子，以及##STR3##其中Q如上；Y从以下组中选择：##STR4##R.sup.1是氢原子或烷基；R.sup.2是氢原子或烷基；R.sup.3是氢原子、卤素原子或烷基；R.sup.4是氢原子、烷基、环烷基、卤素化烷基或卤素原子；R.sup.5是氢原子、烷基、烷氧基、卤素原子、硝基或羟基；R.sup.5连接到X的任意位置，而R.sup.3或R.sup.4连接到Y的任意位置。胺衍生物(I)可用作杀菌剂。
• Amine derivatives, processes for preparing the same and fungicides containing the same
  申请人：Kaken Pharmaceutical Co., Ltd.

  公开号：EP0164697A2

  公开（公告）日：1985-12-18

  Amine derivatives having the general formula (I): wherein X is selected from the group consisting of wherein Q is oxygen, sulfur or nitrogen atom, and wherein Q is as above; Y is selected from the group consisting of R' is hydrogen atom or an alkyl group; R2 is hydrogen atom or an alkyl group; R3 is hydrogen atom, a halogen atom or an alkyl group; R4 is hydrogen atom, an alkyl group, a cycloalkyl group, a halogenated alkyl group or a halogen atom; R5 is hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, nitro group or hydroxy group; R5 is attached to an arbitrary position of X, and R3 or R4 is attached to an arbitrary position of Y. The amine derivatives (II are useful as fungicides.

  具有通式(I)的胺衍生物：其中X选自由Q为氧、硫或氮原子组成的组，Q如上；Y选自由R'为氢原子或烷基；R2为氢原子或烷基；R3为氢原子、卤素原子或烷基；R4为氢原子、烷基、环烷基、卤代烷基或卤素原子；R5为氢原子、烷基、烷氧基、卤素原子、硝基或羟基；R5连接到X的任意位置，R3或R4连接到Y的任意位置。
• Chiral derivatives of Butenafine and Terbinafine: synthesis and antifungal activity
  作者：Erik Fuglseth、Eli Otterholt、Hanne Høgmoen、Eirik Sundby、Colin Charnock、Bård Helge Hoff

  DOI：10.1016/j.tet.2009.09.067

  日期：2009.11

  Two series of allylamines/benzylamines have been synthesised and evaluated for their antifungal activity towards Cryptococcus neoformans. All compounds are chiral derivatives of Butenafine and Terbinafine, having additional substituents at the carbon connected to the central nitrogen atom. In both series. the antifungal activity was strongly dependent on both the steric bulk and the electronic nature of the substituents. Compared to the parent compounds (Butenafine and Terbinafine), the activity was maintained when the hydrogen was replaced with a methyl group. Lower activity was observed for ethyl, whereas introduction of -CH2F, -CHF2, -CF3 or -CN substituents removed all antifungal activity. Testing of (R)- and (S)-N-(4-tert-butylbenzyl)-N-methyl-1-(naphthalen-1-yl)ethanamine against C. neoformans. Cryptococcus diffluens and Trichosporon cutaneum revealed that most of the activity resides in the (R)-enantiomer. The (R)-enantiomer performed as well as, or better (lower MIC values) than Butenafine against each test strain, suggesting that antimycotics based on this compound might be an improvement of existing Butenafine-based formulations. (C) 2009 Elsevier Ltd. All rights reserved.
• Stanetty Peter, Wallner Herbert, Arch. Pharm., 326 (1993) N 6, S 341- 350
  作者：Stanetty Peter, Wallner Herbert

  DOI：——

  日期：——
• US5021458A
  申请人：——

  公开号：US5021458A

  公开（公告）日：1991-06-04