p-nitrophenyl 4-(4,4'-dimethoxytrityloxy)butyrate | 125697-62-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: p-nitrophenyl 4-(4,4'-dimethoxytrityloxy)butyrate
• 英文别名: 4-Nitrophenyl 4-(4,4'-dimethoxytrityloxy)-butyrate；4-Nitrophenyl 4-(4,4'-dimethoxytrityloxy)butyrate；(4-nitrophenyl) 4-[bis(4-methoxyphenyl)-phenylmethoxy]butanoate
• CAS: 125697-62-3
• 化学式: C₃₁H₂₉NO₇
• 分子量: 527.574
• InChiKey: UQMVYWFAURDAPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  39
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  99.8
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  p-nitrophenyl 4-(4,4'-dimethoxytrityloxy)butyrate 以80%的产率得到4-Nitrophenyl 4-[(9-phenyl-9-xanthyl)oxy]-butyrate
  参考文献：
  名称：

  Oligonucleotide-polyamide conjugates

  摘要：

  本文介绍了一种公式为X-L-Y的寡核苷酸-聚酰胺共轭物，其中X为聚酰胺，Y为寡核苷酸，L为连接剂，可形成与聚酰胺X的氨基端和寡核苷酸Y的3'磷酸基团的共价键。可以通过在固体支持基质上组装聚酰胺，加入适当的连接剂分子，然后合成寡核苷酸来合成共轭物。还描述了使用寡核苷酸-聚酰胺共轭物检测特定多核苷酸的方法。

  公开号：

  EP0972779A3
• 作为产物：
  描述：

  对硝基苯酚 、 4,4'-双甲氧基三苯甲基氯 、 sodium 4-hydroxybutanoate 在 N,N'-二环己基碳二亚胺 作用下， 生成 p-nitrophenyl 4-(4,4'-dimethoxytrityloxy)butyrate
  参考文献：
  名称：

  The solid phase synthesis of oligonucleotides containing a 3′-peptide moiety

  摘要：

  DOI：

  10.1016/s0040-4039(00)95628-4

文献信息

• Polyamide-oligonucleotide derivatives, their preparation and use
  申请人：Uhlmann Eugen

  公开号：US20050026817A1

  公开（公告）日：2005-02-03

  Polyamide-oligonucleotide derivatives of the formula F[(DNA-Li) q (PNA-Li) r (DNA-Li) s (PNA) t ] x F′ wherein q, r, s, t are, independently of one another, zero or 1, where the total of two or more adjacent q, r, s and t≧2; x is 1 to 20; DNA is a nucleic acid such as DNA or RNA or a known derivative thereof; Li is a covalent linkage between DNA and PNA, where the covalent linkage comprises a bond or an organic radical with at least one atom from the series consisting of C, N, O or S; PNA is a polyamide structure which contains at least one nucleotide base which is different from thymine; and F and F′ are end groups and/or are linked together by a covalent bond, and the physiologically tolerated salts thereof, a process for their preparation and their use as pharmaceutical, as gene probe and as primer, are described.

  本发明涉及一种多聚酰胺-寡核苷酸衍生物，其化学式为F[(DNA-Li)q(PNA-Li)r(DNA-Li)s(PNA)t]xF'，其中q、r、s、t独立地为0或1，相邻的两个或更多q、r、s和t的总和≧2；x为1到20；DNA是核酸，例如DNA或RNA或其已知衍生物；Li是DNA和PNA之间的共价连接，其中共价连接包括具有来自C、N、O或S系列中至少一个原子的键或有机基团；PNA是含有至少一个不同于胸腺嘧啶的核苷酸碱基的多聚酰胺结构；F和F'为末端基团和/或通过共价键连接在一起，以及其生理上可耐受的盐，描述了其制备过程以及作为制药、基因探针和引物的用途。
• Hybridization-triggered fluorescent detection of nucleic acids
  申请人：Epoch Biosciences, Inc.

  公开号：US20030113765A1

  公开（公告）日：2003-06-19

  Compositions and methods for fluorescent detection of nucleic acids are provided. The compositions can be detected by fluorescence when hybridized to a nucleic acid containing a target sequence, but are non-fluorescent in the non-hybridized state. Alternatively, the fluorescence properties of the compositions change in a detectable manner upon hybridization to a nucleic acid containing a target sequence. Methods for synthesis and methods of use of the compositions are also provided.

  本发明提供了用于荧光检测核酸的组合物和方法。这些组合物在与含有目标序列的核酸杂交时可以通过荧光检测，但在非杂交状态下是非荧光的。 或者，这些组合物的荧光特性在与含有目标序列的核酸杂交时以可检测的方式发生变化。还提供了合成和使用这些组合物的方法。
• ——
  作者：Beatriz G. de la Torre、Juan Carlos Morales、Anna Aviñó、Daniela Iacopino、Andrea Ongaro、Donald Fitzmaurice、Deirdre Murphy、Hugh Doyle、Gareth Redmond、Ramon Eritja

  DOI：10.1002/1522-2675(200209)85:9<2594::aid-hlca2594>3.0.co;2-r

  日期：2002.9

  Oligodeoxynucleotide conjugates 1-15 carrying anchoring groups such as amino, thiol, pyrrole, and carboxy groups were prepared. A post-synthetic modification protocol was developed. In this method 2'-deoxy-O-4-(p-nitrophenyl)uridine-3-phosphoramidite was prepared and incorporated in oligonucleotides. After assembly, the modified nucleoside was made to react with different amines carrying the anchoring groups. At the same time, protecting groups were removed to yield the desired oligonucleotide conjugates. In a second approach, amino, thiol, and carboxylic groups were introduced into the 3'-end of the oligonucleotides by preparing solid supports loaded with the appropriate amino acids. Oligonucleotide-gold conjugates were prepared and their binding properties were examined.
• OLIGONUCLEOTIDE-POLYAMIDE CONJUGATES
  申请人：HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE

  公开号：EP0383803B1

  公开（公告）日：2000-05-03
• EP0383803A4
  申请人：——

  公开号：EP0383803A4

  公开（公告）日：1991-03-20