9-乙氧基甲基-4-甲酰基-3,8-二羟基-1,6-二甲基-11-氧代二苯并[b,e][1,4]二氧杂卓-7-羧酸 | 489-49-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 中文名称: 9-乙氧基甲基-4-甲酰基-3,8-二羟基-1,6-二甲基-11-氧代二苯并[b,e][1,4]二氧杂卓-7-羧酸
• 中文别名: 10,10'-氧代二-5,10-二氢苯并砷嗪并英
• 英文名称: cetraric acid
• 英文别名: 4-(ethoxymethyl)-10-formyl-3,9-dihydroxy-1,7-dimethyl-6-oxobenzo[b][1,4]benzodioxepine-2-carboxylic acid
• CAS: 489-49-6
• 化学式: C₂₀H₁₈O₉
• 分子量: 402.358
• InChiKey: SPLUKWYWJOQKMJ-UHFFFAOYSA-N

物化性质

• 沸点：
  657.9±55.0 °C(Predicted)
• 密度：
  1.480±0.06 g/cm3(Predicted)
• LogP：
  4.930 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  140
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  9-乙氧基甲基-4-甲酰基-3,8-二羟基-1,6-二甲基-11-氧代二苯并[b,e][1,4]二氧杂卓-7-羧酸 、 furan-2,3,5(4H)-trione pyridine (1:1) 、 alkaline earth salt of/the/ methylsulfuric acid 生成 4,5-二甲基间苯二酚
  参考文献：
  名称：

  Ueber Cetrarsäure

  摘要：

  DOI：

  10.1002/ardp.19062440607
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 作用下， 生成 9-乙氧基甲基-4-甲酰基-3,8-二羟基-1,6-二甲基-11-氧代二苯并[b,e][1,4]二氧杂卓-7-羧酸
  参考文献：
  名称：

  Asahina; Tanase, Chemische Berichte, 1934, vol. 67, p. 411,413

  摘要：

  DOI：

文献信息

• HEPTACYCLIC COMPOUNDS AND THE PHARMACEUTICAL USES THEREOF FOR PREVENTING AND TREATING DIABETES AND METABOLIC SYNDROME
  申请人：Shen Jianhua

  公开号：US20100173905A1

  公开（公告）日：2010-07-08

  The invention discloses a new use of a class of heptacyclic compounds in the preparation of formulations for the prevention and treatment of diabetes and metabolic syndromes; the present invention also discloses a new class of heptacyclic compounds; the present invention also discloses a process for preparing the heptacyclic compounds and a composition containing the same. The heptacyclic compounds of the present invention can be used to effectively preventing or treating diseases such as diabetes and metabolic syndromes.

  本发明公开了一类七环化合物在制备用于预防和治疗糖尿病和代谢综合症的配方中的新用途；本发明还公开了一类新的七环化合物；本发明还公开了一种制备七环化合物和含有七环化合物的组成物的方法。本发明的七环化合物可用于有效地预防或治疗糖尿病和代谢综合症等疾病。
• Magnetic recording medium and cleaning tape
  申请人：SONY CORPORATION

  公开号：EP0827135A1

  公开（公告）日：1998-03-04

  This invention provides a magnetic recording medium which, even when the friction time is prolonged or the scan speed is increased to achieve a long time recording, will leave no burnt matters onto a magnetic head, reduce spacing loss , and prevent an increase in error rate. This invention also provides a cleaning tape which, without causing any wear and damage of a magnetic head, will remove the head of burnt matters adherent thereto. They are actually a magnetic recording medium and cleaning tape which hold an antiseize agent containing a compound with a pyridine skeleton and two or more ligand sites. Alternatively, they are a magnetic recording medium and cleaning tape which hold an antiseize agent containing a diketone compound. The antiseize agent may contain a titanium coupling agent, carboxylic acid, and phosphor-containing compound, in addition to the above compound.

  本发明提供了一种磁记录介质，即使延长摩擦时间或提高扫描速度以实现长时间记录，也不会在磁头上留下烧焦物，减少间距损失，并防止错误率增加。本发明还提供了一种清洁带，它能在不对磁头造成任何磨损和损坏的情况下清除磁头上附着的烧焦物。 它们实际上是一种磁记录介质和清洁磁带，其中含有一种抗咬合剂，这种抗咬合剂含有一种具有吡啶骨架和两个或两个以上配位位点的化合物。或者，它们是一种磁记录介质和清洁胶带，其中含有一种含二酮化合物的抗咬合剂。除上述化合物外，防卡剂还可能含有钛偶联剂、羧酸和含磷化合物。
• COMPOUNDS WITH 7-MEMBER CYCLE AND THE PHARMACEUTICAL USE THEREOF FOR PREVENTING AND TREATING DIABETES AND METABOLISM SYNDROME
  申请人：Shanghai Institute of Materia Medica, Chinese Academy of Sciences

  公开号：EP2199295A1

  公开（公告）日：2010-06-23

  The invention discloses a new use of a class of heptacyclic compounds in the preparation of formulations for the prevention and treatment of diabetes and metabolic syndromes; the present invention also discloses a new class of heptacyclic compounds; the present invention also discloses a process for preparing the heptacyclic compounds and a composition containing the same. The heptacyclic compounds of the present invention can be used to effectively preventing or treating diseases such as diabetes and metabolic syndromes.

  本发明公开了一类庚环化合物在制备预防和治疗糖尿病和代谢综合征的制剂中的新用途；本发明还公开了一类新的庚环化合物；本发明还公开了制备庚环化合物和含有庚环化合物的组合物的工艺。本发明的庚环化合物可用于有效预防或治疗糖尿病和代谢综合征等疾病。
• Nanogel networks including polyion polymer fragments and biological agent compositions thereof
  申请人：——

  公开号：US20020136769A1

  公开（公告）日：2002-09-26

  The present invention relates to nanogel networks having at least one cross-linked polyionic polymer fragment and at least one nonionic water-soluble polymer fragment, and compositions thereof, having at least one suitable biological agent.

  本发明涉及具有至少一种交联聚阴离子聚合物片段和至少一种非离子水溶性聚合物片段的纳米凝胶网络及其组合物，其中含有至少一种合适的生物制剂。
• Cross-linked ionic core micelles
  申请人：UNIVERSITY OF NEBRASKA BOARD OF REGENTS

  公开号：US20040228823A1

  公开（公告）日：2004-11-18

  The present invention provides polymer micelles with cross-linked ionic cores as delivery vehicles for therapeutics, diagnostics, nucleic acids, proteins, small molecules and the like. The present invention provides additionally methods of synthesis and uses for such micelles.

  本发明提供具有交联离子核的聚合物胶束，作为治疗、诊断、核酸、蛋白质、小分子等的输送载体。本发明还提供了此类胶束的合成方法和用途。