2-(4-benzylpiperidin-1-yl)-1-chloroethane | 109870-35-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-(4-benzylpiperidin-1-yl)-1-chloroethane
• 英文别名: 2-(4-benzyl-1-piperidinyl)ethyl chloride；2-(4-benzylpiperidino)-1-chloro ethane；4-benzyl-1-(2-chloroethyl)piperidine；2-(4-benzylpiperidino)chloroethane；4-benzyl-1-(2-chloro-ethyl)-piperidine；N-(2-Chloraethyl)-4-benzylpiperidin
• CAS: 109870-35-1
• 化学式: C₁₄H₂₀ClN
• mdl: MFCD14614578
• 分子量: 237.772
• InChiKey: BBDCCXMBOJDLMO-UHFFFAOYSA-N

物化性质

• 沸点：
  330.0±25.0 °C(Predicted)
• 密度：
  1.057±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(4-benzylpiperidin-1-yl)-1-chloroethane 、 4-羟基苯硫酚 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 18.0h， 生成 4-[2-(4-Benzyl-piperidin-1-yl)-ethylsulfanyl]-phenol
  参考文献：
  名称：

  一系列亚型选择性NMDA受体拮抗剂的平行合成。

  摘要：

  通过使用平行合成快速研究了一系列的1-（杂芳硫基烷基）-4-苄基哌啶，以研究其对NR1A / 2B受体亚型的结合亲和力。

  DOI：

  10.1016/s0960-894x(00)00035-4
• 作为产物：
  描述：

  2-(4-benzyl-piperidin-1-yl)-ethanol 在 氯化亚砜 作用下， 以 氯仿 为溶剂， 生成 2-(4-benzylpiperidin-1-yl)-1-chloroethane
  参考文献：
  名称：

  一系列亚型选择性NMDA受体拮抗剂的平行合成。

  摘要：

  通过使用平行合成快速研究了一系列的1-（杂芳硫基烷基）-4-苄基哌啶，以研究其对NR1A / 2B受体亚型的结合亲和力。

  DOI：

  10.1016/s0960-894x(00)00035-4

文献信息

• Polycyclic amine compounds and their enantiomers, their method of
  申请人：Elf Sanofi

  公开号：US05340822A1

  公开（公告）日：1994-08-23

  The invention relates to polycyclic amine compounds of formula (I) ##STR1## where Y. m. Ar', n, p, Q, T, q and Z are defined herein. The invention also relates to methods of making the compounds of formula (I) and pharmaceutical compositions which contain the compounds of formula (I). The inventive compounds are useful as neurokinin receptor antagonists, and are useful for the treatment of any substance P-dependent and neurokinin-dependent pathological condition.

  该发明涉及公式（I）的多环胺化合物 其中Y、m、Ar'、n、p、Q、T、q和Z在此处被定义。该发明还涉及制备公式（I）化合物的方法和含有公式（I）化合物的药物组合物。这些创新化合物可用作神经激肽受体拮抗剂，适用于治疗任何物质P依赖性和神经激肽依赖性的病理状况。
• Aromatic derivatives, their preparation and their use as antimicrobial
  申请人：Sanofi

  公开号：US04916156A1

  公开（公告）日：1990-04-10

  The present invention relates to aromatic derivatives of the formula: ##STR1## in which: n represents an integer between 2 and 10; R.sub.1 and R.sub.2 are identical or different and represent a cycloalkyl containing 3 to 6 carbon atoms or an alkyl containing from 1 to 6 carbon atoms which is unsubstituted or substituted by a phenyl or benzyl group; or R.sub.1 and R.sub.2, together with the nitrogen atom to which they are bonded, form a heterocycle selected from pyrrolidin-1-yl, piperidino, azepin-1-yl, hexamethyleneimino, 4-methylpiperidino, 4-benzylpiperidino, 4-phenylpiperidino, 1,2,3,4-tetrahydroisoquinol-2-yl, morpholino and imidazol-1-yl groups; R.sub.3 represents a hydrogen, a halogen, a methyl or a phenyl; R.sub.4 represents a hydrogen, a halogen or a methyl; or R.sub.3 and R.sub.4, taken together with the benzene ring to which they are bonded, form a naphth-1-yl or naphth-2-yl group; Y represents a direct bond, a methyleneoxy group, a methylenethio group or a vinylene group; and R.sub.5 represents an alkyl containing from 5 to 18 carbon atoms, a cycloalkyl containing from 3 to 8 carbon atoms, an adamantyl, naphth-1-yl or naphth-2-yl group, an unsubstituted phenyl group or a phenyl group substituted by one or 2 substituents selected from halogen atoms, the trifluoromethyl group, the nitro group and the phenyl group; and to their salts with mineral or organic acids.

  本发明涉及公式为：##STR1## 的芳香族衍生物，其中：n表示介于2和10之间的整数；R.sub.1和R.sub.2相同或不同，表示含有3至6个碳原子的环烷基或含有1至6个碳原子的烷基，该烷基未被取代或被苯基或苄基取代；或者R.sub.1和R.sub.2与它们结合的氮原子一起形成从吡咯烷-1-基、哌啶基、氮杂环-1-基、六亚甲基、4-甲基哌啶基、4-苄基哌啶基、4-苯基哌啶基、1,2,3,4-四氢异喹啉-2-基、吗啉和咪唑-1-基中选择的杂环；R.sub.3表示氢、卤素、甲基或苯基；R.sub.4表示氢、卤素或甲基；或者R.sub.3和R.sub.4与它们结合的苯环一起形成萘-1-基或萘-2-基；Y表示直接键、亚甲氧基、亚甲硫基或乙烯基；R.sub.5表示含有5至18个碳原子的烷基、含有3至8个碳原子的环烷基、金刚烷基、萘-1-基或萘-2-基、未被取代的苯基或被卤素原子、三氟甲基基团、硝基和苯基中的1或2个取代基取代的苯基；以及它们与矿物酸或有机酸的盐。
• Antimicrobial aromatic derivatives substituted by an (omega amino)
  申请人：Sanofi

  公开号：US04820717A1

  公开（公告）日：1989-04-11

  The present invention relates to new aromatic derivatives of formula: ##STR1## wherein: Alk is an alkylene group with 1 to 10 carbon atoms, R.sub.1 is hydrogen or an alkyl with 1 to 6 carbon atoms, R.sub.2 and R.sub.3 are similar or different and represent a cycloalkyl with 3 to 6 carbon atoms or a striaght or branched alkyl with 1 to 6 carbon atoms, either substituted or non-substituted by a phenyl or methyl phenyl group, or R.sub.2 and R.sub.3 form, together with the atom of nitrogen to which they are bonded, a mono-nitrogenous heterocycle containing no other heteroatom, such as pyrrolidino, piperidino, azepino, hexamethylene-imino, 4-methyl-piperidino, 4-phenyl-piperidino, 1,2,3,4-tetrahydro-2-isoquinolyl, 4-benzyl-piperidino; R.sub.4 is hydrogen, halogen, methyl or phenyl, R.sub.5 is hydrogen, halogen or methyl, or R.sub.4 and R.sub.5 together with the benzene ring to which they are bonded, constitute a 1-naphthyl or 2-naphthyl group, and the pharmaceutically acceptable salts with mineral or organic acids. The invention compounds possess interesting antimicrobial properties.

  本发明涉及公式为：##STR1##的新芳香衍生物，其中：Alk是具有1到10个碳原子的烷基，R.sub.1是氢或具有1到6个碳原子的烷基，R.sub.2和R.sub.3相似或不同，代表具有3到6个碳原子的环烷基或直链或支链的具有1到6个碳原子的烷基，可以是取代或非取代的苯基或甲基苯基基团，或R.sub.2和R.sub.3与它们结合的氮原子一起形成不含其他杂原子的单氮杂环，例如吡咯啉基，哌啶基，氮杂二环己烷基，己烷亚甲基，4-甲基哌啶基，4-苯基哌啶基，1,2,3,4-四氢-2-异喹啉基，4-苄基哌啶基；R.sub.4是氢，卤素，甲基或苯基，R.sub.5是氢，卤素或甲基，或R.sub.4和R.sub.5与它们结合的苯环一起构成1-萘基或2-萘基基团，以及与矿物质或有机酸形成的药物可接受的盐。本发明化合物具有有趣的抗微生物活性。
• Aromatic derivatives and their use as antimicrobial agents
  申请人：Sanofi

  公开号：US05089251A1

  公开（公告）日：1992-02-18

  The present invention relates to aromatic derivatives of the formula: ##STR1## in which: n represents an integer between 2 and 10; R.sub.1 and R.sub.2 are identical or different and represent a cycloalkyl containing 3 to 6 carbon atoms or an alkyl containing from 1 to 6 carbon atoms which is unsubstituted or substituted by a phenyl or benzyl group; or R.sub.1 and R.sub.2, together with the nitrogen atom to which they are bonded, form a heterocycle selected from pyrrolidin-1-yl, piperidino, azepin-1-yl, hexamethyleneimino, 4-methylpiperidino, 4-benzylpiperidino, 4-phenylpiperidino, 1,2,3,4-tetrahydroisoquinol-2-yl, morpholino and imidazol-1-yl groups; R.sub.3 represents a hydrogen, a halogen, a methyl or a phenyl; R.sub.4 represents a hydrogen, a halogen or a methyl; or R.sub.3 and R.sub.4, taken together with the benzene ring to which they are bonded, form a naphth-1-yl or naphth-2-yl group; Y represents a direct bond, a methyleneoxy group, a methylenethio group or a vinylene group; and R.sub.5 represents an alkyl containing from 5 to 18 carbon atoms, a cycloalkyl containing from 3 to 8 carbon atoms, an adamantyl, naphth-1-yl or naphth-2-yl group, an unsubstituted phenyl group or a phenyl group substituted by one or 2 substituents selected from halogen atoms, the trifluoromethyl group, the nitro group and the phenyl group; and to their salts with mineral or organic acids. Application: antimicrobial agents.

  本发明涉及公式为：##STR1## 的芳香族衍生物，其中：n表示2至10之间的整数；R.sub.1和R.sub.2相同或不同，表示含有3至6个碳原子的环烷基或含有1至6个碳原子的烷基，该烷基未被取代或被苯基或苄基取代；或R.sub.1和R.sub.2与它们所连接的氮原子一起形成选自吡咯烷-1-基、哌啶基、氮杂环己烷-1-基、六亚甲基、4-甲基哌啶基、4-苄基哌啶基、4-苯基哌啶基、1,2,3,4-四氢异喹啉-2-基、吗啉和咪唑-1-基的杂环；R.sub.3表示氢、卤素、甲基或苯基；R.sub.4表示氢、卤素或甲基；或R.sub.3和R.sub.4与它们所连接的苯环一起形成萘-1-基或萘-2-基；Y表示直接键、亚甲氧基、亚甲硫基或乙烯基；R.sub.5表示含有5至18个碳原子的烷基、含有3至8个碳原子的环烷基、金刚烷基、萘-1-基或萘-2-基、未取代的苯基或被卤素原子、三氟甲基基团、硝基基团和苯基中的1个或2个取代基取代的苯基；以及它们与矿物酸或有机酸的盐。应用：抗微生物剂。
• Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof
  申请人：Ishikawa, Masayuki

  公开号：EP0040793A1

  公开（公告）日：1981-12-02

  A 5,6,7-substituted-2,4 (1H,3H)-quinazolinedione compound of the formula (I), wherein R1, R2, R3, A and B as defined in claim 1 and its acid addition salt; and a vasodilating and hypotensive composition containing the aforesaid compound.

  一种式（I）的 5，6，7-取代的-2，4（1H，3H）-喹唑啉二酮化合物、 其中 R1、R2、R3、A 和 B 如权利要求 1 所定义及其酸加成盐；以及含有上述化合物的血管扩张和降血压组合物。