5-<1-(3-methoxylphenyl)-4-piperazino>methyl-2-amino-2-oxazoline | 144722-84-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-<1-(3-methoxylphenyl)-4-piperazino>methyl-2-amino-2-oxazoline
• 英文别名: 5-[1-(3-methoxyphenyl)-4-piperazinyl]methyl-2-amino-2-oxazoline；4,5-Dihydro-5-((4-(3-methoxyphenyl)-1-piperazinyl)methyl)-2-oxazolamine；5-[[4-(3-methoxyphenyl)piperazin-1-yl]methyl]-4,5-dihydro-1,3-oxazol-2-amine
• CAS: 144722-84-9
• 化学式: C₁₅H₂₂N₄O₂
• 分子量: 290.365
• InChiKey: JHNZJFIWXSOTQM-UHFFFAOYSA-N

物化性质

• 沸点：
  463.7±55.0 °C(Predicted)
• 密度：
  1.29±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  63.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-(3-甲氧基苯基)哌嗪 以 甲醇 、 乙醇 为溶剂， 反应 36.0h， 生成 5-<1-(3-methoxylphenyl)-4-piperazino>methyl-2-amino-2-oxazoline
  参考文献：
  名称：

  Synthesis and antidepressant activity of 5-(1-aryl-4-piperazino)methyl-2-amino-2-oxazolines

  摘要：

  The synthesis of 20 5-(1-aryl-4-piperazino)methyl-2-amino-2-oxazolines is described. Antidepressant activity was observed in mice using classical screening tests. Structure-activity relationships were studied and correlated with the nature of the aromatic substituent. Preliminary lipophilic and electronic properties of one lead compound (COR 3224) have been described.

  DOI：

  10.1016/0223-5234(92)90177-3

文献信息

• Bosc Jean Jacques, Forfar Isabelle, Jarry Christian, Laguerre Michel, Car+, Arch. Pharm., 327 (1994) N 3, S 187-192
  作者：Bosc Jean Jacques, Forfar Isabelle, Jarry Christian, Laguerre Michel, Car+

  DOI：——

  日期：——
• Synthesis and antidepressant activity of 5-(1-aryl-4-piperazino)methyl-2-amino-2-oxazolines
  作者：JJ Bosc、C Jarry、A Carpy、E Panconi、P Descas

  DOI：10.1016/0223-5234(92)90177-3

  日期：1992.8

  The synthesis of 20 5-(1-aryl-4-piperazino)methyl-2-amino-2-oxazolines is described. Antidepressant activity was observed in mice using classical screening tests. Structure-activity relationships were studied and correlated with the nature of the aromatic substituent. Preliminary lipophilic and electronic properties of one lead compound (COR 3224) have been described.