Methyl 8-azabicyclo[3.2.1]octane-8-carboxylate | 1005389-51-4

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: Methyl 8-azabicyclo[3.2.1]octane-8-carboxylate
• CAS: 1005389-51-4
• 化学式: C₉H₁₅NO₂
• 分子量: 169.224
• InChiKey: JAXYJRAJHYCGOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Methyl 8-azabicyclo[3.2.1]octane-8-carboxylate 在 碘代三甲硅烷 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 降莨菪鹼
  参考文献：
  名称：

  Efficient oxidation of alcohols electrochemically mediated by azabicyclo-N-oxyls

  摘要：

  Preparation of azabicyclo-N-oxyls and the electrochemical oxidation of alcohols using them as mediators have been exploited. This oxidation was applicable to a transformation of sterically hindered secondary alcohols into the corresponding ketones in high yields. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.11.016
• 作为产物：
  描述：

  methyl (1R,3s,5S)-3-chloro-8-azabicyclo[3.2.1]octane-8-carboxylate 在 Raney-Ni W-2 氢氧化钾 、 氢气 作用下， 以90%的产率得到Methyl 8-azabicyclo[3.2.1]octane-8-carboxylate
  参考文献：
  名称：

  Efficient oxidation of alcohols electrochemically mediated by azabicyclo-N-oxyls

  摘要：

  Preparation of azabicyclo-N-oxyls and the electrochemical oxidation of alcohols using them as mediators have been exploited. This oxidation was applicable to a transformation of sterically hindered secondary alcohols into the corresponding ketones in high yields. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.11.016

文献信息

• [EN] ALKYL 3-((2-AMIDOETHYL)AMINO)-8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE ANALOGS AS SELECTIVE M1 AGONISTS AND METHODS OF MAKING AND USING SAME<br/>[FR] ANALOGUES DE 3-((2-AMIDOÉTHYL)AMINO)-8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE D'ALKYLE COMME AGONISTES SÉLECTIFS POUR M1 ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：UNIV VANDERBILT

  公开号：WO2011087812A1

  公开（公告）日：2011-07-21

  In one aspect, the invention relates to compounds having a general structure: which are useful as selective allosteric or bitopic agonists of the M1 muscarinic receptor; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurodegenerative diseases, including Alzheimer's Disease. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• Efficient oxidation of alcohols electrochemically mediated by azabicyclo-N-oxyls
  作者：Yosuke Demizu、Hirofumi Shiigi、Takahisa Oda、Yoshihiro Matsumura、Osamu Onomura

  DOI：10.1016/j.tetlet.2007.11.016

  日期：2008.1

  Preparation of azabicyclo-N-oxyls and the electrochemical oxidation of alcohols using them as mediators have been exploited. This oxidation was applicable to a transformation of sterically hindered secondary alcohols into the corresponding ketones in high yields. (C) 2007 Elsevier Ltd. All rights reserved.