1-丙酰基-4-哌啶酮 | 91623-91-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-丙酰基-4-哌啶酮
• 英文名称: 1-propionyl-4-piperidone
• 英文别名: 1-Propanoylpiperidin-4-one
• CAS: 91623-91-5
• 化学式: C₈H₁₃NO₂
• mdl: MFCD09948033
• 分子量: 155.197
• InChiKey: QOLXLZRNPULJIL-UHFFFAOYSA-N

物化性质

• 沸点：
  237.2±15.0 °C(Predicted)
• 密度：
  1.094±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-丙酰基-4-哌啶酮 在 titanium(IV) isopropylate 、 palladium on activated charcoal 、 甲酸铵 、 sodium cyanoborohydride 、 三乙胺 作用下， 以 甲醇 、 乙醇 、 乙腈 为溶剂， 生成 4-fluoro-N-(1-propionyl-piperidin-4-yl)-benzenesulfonamide
  参考文献：
  名称：

  4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs

  摘要：

  Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-amino-piperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9. active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer's disease. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00437-2
• 作为产物：
  描述：

  4-氧代哌啶酮盐酸盐 、 丙酰氯 在 potassium carbonate 作用下， 以 氯仿 为溶剂， 以72%的产率得到1-丙酰基-4-哌啶酮
  参考文献：
  名称：

  4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs

  摘要：

  Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-amino-piperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9. active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer's disease. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00437-2

文献信息

• [EN] OXASPIRO [2.5] OCTANE DERIVATIVES AND ANALOGS<br/>[FR] DÉRIVÉS D'OXASPIRO[2.5]OCTANE ET ANALOGUES
  申请人：ZAFGEN CORP

  公开号：WO2012122264A1

  公开（公告）日：2012-09-13

  The invention provides oxaspiro[2.5]octane derivatives and analogs, methods for preparation thereof, intermediates thereto, pharmaceutical compositions, and uses thereof in the treatment of various disorders and conditions, such as overweight and obesity.

  这项发明提供了氧杂螺[2.5]辛烷衍生物和类似物，其制备方法，中间体，药物组合物以及在治疗各种疾病和状况中的用途，例如超重和肥胖。
• [EN] SPIRO[CYCLOBUTANE-1,3'-INDOLIN]-2'-ONE DERIVATIVES AS BROMODOMAIN INHIBITORS<br/>[FR] DÉRIVÉS SPIRO [CYCLOBUTANE -1,3 '-INDOLIN] -2 '-ONE UTILISÉS EN TANT QU'INHIBITEURS DE BROMODOMAINES
  申请人：ORION CORP

  公开号：WO2016203112A1

  公开（公告）日：2016-12-22

  The present invention provides novel spiro[cyclobutane-1,3'-indolin]-2'- derivatives of formula (I) in which Cy R1, R2, R4, L and 'm' are have the meaning given in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula (I) are useful as bromodomain inhibitors in the treatment or prevention of diseases or disorders where bromodomain inhibition is desired.

  本发明提供了具有式(I)的新颖螺环[环丁烷-1,3'-吲哚]-2'-衍生物，其中Cy、R1、R2、R4、L和'm'的含义如规范中所述，并且其药用盐。式(I)的化合物在需要溴域抑制的疾病或疾病的治疗或预防中作为溴域抑制剂是有用的。
• POLYMER CONJUGATES OF GLP-1
  申请人：Bossard Mary J.

  公开号：US20100210505A1

  公开（公告）日：2010-08-19

  Conjugates of a GLP-I moiety may be covalently attached to one or more water-soluble polymers. For instance, a GLP-I polymer conjugate may include a GLP-I moiety releasably attached at its N-terminus to a water-soluble polymer. The GLP-I polymer conjugate may include a GLP-I moiety covalently attached to a water-soluble polymer, wherein the GLP-I moiety possesses an N-methyl substituent. The GLP-I polymer conjugate may include a GLP-I moiety covalently attached at a polymer attachment site to a water-soluble polymer, wherein the GLP-I moiety is glycosylated at a site separate from the polymer attachment site.

  GLP-I基团的共轭物可以共价地附加在一个或多个水溶性聚合物上。例如，GLP-I聚合物共轭物可以包括一个GLP-I基团可释放地附着在其N-末端到水溶性聚合物上。GLP-I聚合物共轭物可以包括一个GLP-I基团共价附着在水溶性聚合物上，其中GLP-I基团具有一个N-甲基取代基。GLP-I聚合物共轭物可以包括一个GLP-I基团共价附着在聚合物附着位点到水溶性聚合物上，其中GLP-I基团在与聚合物附着位点分离的位点被糖基化。
• Oxaspiro[2.5]Octane Derivatives and Analogs
  申请人：Vath James E.

  公开号：US20150045427A1

  公开（公告）日：2015-02-12

  The invention provides oxaspiro[2.5]octane derivatives and analogs, methods for preparation thereof, intermediates thereto, pharmaceutical compositions, and uses thereof in the treatment of various disorders and conditions, such as overweight and obesity.

  本发明提供了氧杂螺[2.5]辛烷衍生物和类似物，其制备方法，中间体，制药组合物以及在治疗各种疾病和病况（例如超重和肥胖）中的应用。
• SULFONYL CONTAINING BENZOTHIAZOLE INHIBITORS OF ENDOTHELIAL LIPASE
  申请人：Bristol-Myers Squibb Company

  公开号：US20140011799A1

  公开（公告）日：2014-01-09

  The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.

  本发明提供了公式(I)的化合物：如规范中所定义的和包含任何此类新化合物的组合物。这些化合物是内皮细胞脂肪酶抑制剂，可用作药物。