4-fluoroisobutyrylfentanyl | 244195-32-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-fluoroisobutyrylfentanyl
• 英文别名: 4-FiBF；4-Fluoroisobutyryl fentanyl；N-(4-fluorophenyl)-2-methyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
• CAS: 244195-32-2
• 化学式: C₂₃H₂₉FN₂O
• 分子量: 368.494
• InChiKey: OZDOSQNUJIXEOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-fluoroisobutyrylfentanyl 在 盐酸 作用下， 生成 4-Fluoroisobutyrfentanyl hydrochloride
  参考文献：
  名称：

  Evaluation of Agonistic Activity of Fluorinated and Nonfluorinated Fentanyl Analogs on μ-Opioid Receptor Using a Cell-Based Assay System

  摘要：

  使用基于细胞的检测系统研究了含氟和不含氟的芬太尼类似物在μ-阿片受体上的拮抗活性。根据活性，芬太尼类似物的排名如下：芬太尼 > 异丁酰芬太尼 ≈ 丁酰芬太尼 ≈ 甲氧基乙酰芬太尼 > 乙酰芬太尼。然而，在N-苯环上含氟的芬太尼类似物中，2-氟类似物显示出最强活性，而3-氟类似物显示出最弱活性。这些结果表明，2-氟化的芬太尼类似物更可能导致中毒。

  DOI：

  10.1248/bpb.b20-00780
• 作为产物：
  描述：

  N-(2-苯乙基)-4-哌啶酮 在 sodium tetrahydroborate 作用下， 生成 4-fluoroisobutyrylfentanyl
  参考文献：
  名称：

  Evaluation of Agonistic Activity of Fluorinated and Nonfluorinated Fentanyl Analogs on μ-Opioid Receptor Using a Cell-Based Assay System

  摘要：

  使用基于细胞的检测系统研究了含氟和不含氟的芬太尼类似物在μ-阿片受体上的拮抗活性。根据活性，芬太尼类似物的排名如下：芬太尼 > 异丁酰芬太尼 ≈ 丁酰芬太尼 ≈ 甲氧基乙酰芬太尼 > 乙酰芬太尼。然而，在N-苯环上含氟的芬太尼类似物中，2-氟类似物显示出最强活性，而3-氟类似物显示出最弱活性。这些结果表明，2-氟化的芬太尼类似物更可能导致中毒。

  DOI：

  10.1248/bpb.b20-00780

文献信息

• NASAL DRUG PRODUCTS AND METHODS OF THEIR USE
  申请人：Adapt Pharma Limited

  公开号：US20170071851A1

  公开（公告）日：2017-03-16

  Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided.
• FENTANYL ANALOGUE DETECTION METHODS AND KITS THEREOF
  申请人：Veriteque USA, Inc.

  公开号：US20220390439A1

  公开（公告）日：2022-12-08

  A portable detection kit for identifying the presence of narcotic compounds (NCs) includes at least one chemical dye, a catalytic reagent, at least one solvent, and a least one surfactant. The at least one dry chemical dye is configured to undergo physic-chemical interaction with at least one predetermined NC to produce a color visible change. The at least one predetermined NC is selected from the group consisting of fentanyl analogues (FAs) and narcotics containing nitrogen heterocyclic moiety.
• [EN] IN-FIELD COLOUR TEST FOR SCREENING FENTANYL AND ANALOGUES THEREOF<br/>[FR] TEST DE COULEUR IN SITU POUR LE CRIBLAGE DE FENTANYLE ET D'ANALOGUES DE CE DERNIER
  申请人：UNIV SYDNEY TECHNOLOGY

  公开号：WO2021184082A1

  公开（公告）日：2021-09-23

  A method of detecting the presence of fentanyl or a fentanyl analogue in a sample which comprises contacting the sample with a 1,2 naphthoquinone (such as 1,2-naphthoquinone itself) in a solvent, preferably acetonitrile, and observing a colour change, which when present, correlates with the presence of fentanyl or a fentanyl analogue. Optionally, a buffer may be provided to maintain an alkaline environment and/or a metal halide catalyst and/or light source may be added to accelerate colour development.