| 1414891-07-8

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• CAS: 1414891-07-8
• 化学式: C₉H₁₈SeSi
• 分子量: 233.287
• InChiKey: QXOZGDNNUQQVRG-UHFFFAOYSA-N

物化性质

• 沸点：
  231.7±23.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.75
• 重原子数：
  11.0
• 可旋转键数：
  3.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  、 叠氮苯 在 四丁基氟化铵 、 copper diacetate 、 sodium ascorbate 作用下， 以 四氢呋喃 为溶剂， 以55%的产率得到
  参考文献：
  名称：

  4-Organochalcogenoyl-1H-1,2,3-triazoles: synthesis and functionalization by a nickel-catalyzed Negishi cross-coupling reaction

  摘要：

  A general method for the synthesis of triazoles containing selenium and tellurium was accomplished via a CuCAAC reaction between organic azides and a terminal triple bond, generated by in situ deprotection of the silyl group. The reaction tolerates alkyl and arylazides, with alkyl and aryl substituents directly bonded to the chalcogen atom. The products were readily functionalized by a nickel-catalyzed Negishi cross-coupling reaction, furnishing the aryl-heteroaryl products at the 4-position in good yields. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.09.062

文献信息

• Ytterbium-catalyzed formal [4+2] cycloaddition: Synthesis of chalcogen-quinolines 3-unsubstituted
  作者：Isadora M. de Oliveira、Mariana P. Darbem、C. Henrique A. Esteves、Daniel C. Pimenta、Julio Zukerman-Schpector、Hélio A. Stefani、Flávia Manarin

  DOI：10.1016/j.tetlet.2018.09.022

  日期：2018.10

  A regioselective ytterbium-catalyzed annulation reaction between ethylglyoxalate, anilines and silyl-alkynes bearing selenyl- and telluryl-moieties for the formation of poly-substituted quinolones is described. A series of examples formed under mild conditions are presented, including a scaled-up reaction and a study on catalyst recyclability.

  描述了乙二醛酸乙二酸酯，苯胺和带有硒烯基和碲基部分的甲硅烷基炔烃之间的区域选择性催化的环化反应，用于形成多取代的喹诺酮。提出了在温和条件下形成的一系列实例，包括放大反应和研究催化剂的可回收性。
• Copper(<scp>i</scp>)/succinic acid cooperatively catalyzed one-pot synthesis of organoselenium-propargylamines <i>via</i> A³-coupling
  作者：Isadora M. de Oliveira、Daniel C. Pimenta、Julio Zukerman-Schpector、Hélio A. Stefani、Flávia Manarin

  DOI：10.1039/c8nj01543k

  日期：——

  Selenium propargylamines were synthesized via an A3-coupling approach using piperidine, p-methoxybenzaldehyde, and trimethylsilyl selenium–acetylene, catalyzed by copper(I) chloride and succinic acid as an additive, in good to excellent yields. This method is advantageous in that desilylation of the trimethylsilyl selenium–acetylene occurs in situ. The reaction time was monitored by FTIR studies and

  硒炔丙基胺是通过哌啶，对甲氧基苯甲醛和三甲基甲硅烷基硒-乙炔，以氯化铜（I）和琥珀酸为添加剂，通过A 3偶联方法合成的，收率良好。该方法的优势在于原位发生了三甲基甲硅烷基硒-乙炔的甲硅烷基化反应。通过FTIR研究监测反应时间，并描述了可能的机理。放大也以令人满意的产率进行。这些硒炔丙基胺可以被氢卤化以合成卤化亚硒基。立体化学由正丁基锂和偶联常数（J1 H NMR光谱中的）值。乙烯基硒化物用于Sonogashira交叉偶联反应中，生成相应的烯炔，收率从中等到良好。