(2-ethoxyphenyl)diphenylmethanol | 110247-86-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (2-ethoxyphenyl)diphenylmethanol
• 英文别名: (2-ethoxy-phenyl)-diphenyl-methanol；(2-Aethoxy-phenyl)-diphenyl-methanol；(2-Ethoxyphenyl)-diphenylmethanol
• CAS: 110247-86-4
• 化学式: C₂₁H₂₀O₂
• 分子量: 304.389
• InChiKey: LXJKVTKZBILTOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2-ethoxyphenyl)diphenylmethanol 在 甲酸 作用下， 生成 2-benzhydryl-phenetole
  参考文献：
  名称：

  852.自由基和自由基的稳定性。第十四部分。（乙氧基苯基）二苯基甲醇和自由基（邻乙氧基苯基）-二苯基甲基

  摘要：

  DOI：

  10.1039/jr9570004240
• 作为产物：
  描述：

  1-乙氧基-2-碘-苯 、 苯频哪醇 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 20.08h， 以70%的产率得到(2-ethoxyphenyl)diphenylmethanol
  参考文献：
  名称：

  频哪醇反应的钠-基自由基阴离子及其与碘代芳烃的偶联

  摘要：

  提出了在芳基碘化物和频哪醇之间无过渡金属的C–C键形成。薄荷醇很容易通过用NaH质子化而转化成其Na-pinacolates。室温下C–C键均质分解会原位生成相应的Na-酮基自由基阴离子，这些阴离子与各种芳基碘化物在均相芳族取代反应中反应，形成叔Na-醇盐。质子化最终以前所未有的方式提供了叔醇。

  DOI：

  10.1021/acs.orglett.6b02184

文献信息

• Amino acid loaded trityl alcohol resins, method of production of amino acid loaded trityl alcohol resins and therapeutics produced therewith
  申请人：Rohm and Haas Company

  公开号：EP1447408A1

  公开（公告）日：2004-08-18

  The present invention relates to a process for making a biologically active substance or therapeutic agent free of a chlorotrityl chloride linker-resin. The process includes reacting an activated amino acid or activated amino acid derivative with a substituted or unsubstituted trityl alcohol resin to obtain a resin-CT-AA product; and, reacting the resin-CT-AA product with other building blocks of the biologically active substance or therapeutic agent to obtain said biologically active substance or therapeutic. A product created by this process is also provided herein. The invention is particularly useful to create T-20 and T-1249 therapeutics.

  本发明涉及一种制造不含氯化三苯酯连接体-树脂的生物活性物质或治疗剂的工艺。该工艺包括使活化氨基酸或活化氨基酸衍生物与取代或未取代的三苯甲醇树脂反应，得到树脂-CT-AA 产物；以及使树脂-CT-AA 产物与生物活性物质或治疗剂的其他结构单元反应，得到所述生物活性物质或治疗剂。本发明还提供了通过该工艺制作的产品。本发明尤其适用于制造 T-20 和 T-1249 治疗剂。
• PROCESS FOR PREPARING HIGH-REACTIVITY ISOBUTENE HOMO- OR COPOLYMERS
  申请人：BASF SE

  公开号：EP3416991A1

  公开（公告）日：2018-12-26
• Amino acid loaded trityl alcohol resins, method of production of amino acid loaded trityl alcohol resins and biologically active substances and therapeutics produced therewith
  申请人：——

  公开号：US20040158037A1

  公开（公告）日：2004-08-12

  The present invention relates to a process for making a biologically active substance or therapeutic agent free of a chlorotrityl chloride linker-resin. The process includes reacting an activated amino acid or activated amino acid derivative with a substituted or unsubstituted trityl alcohol resin to obtain a resin-CT-AA product; and, reacting the resin-CT-AA product with other building blocks of the biologically active substance or therapeutic agent to obtain said biologically active substance or therapeutic. A product created by this process is also provided herein. The invention is particularly useful to create T-20 and T-1249 therapeutics.
• [EN] PROCESS FOR PREPARING HIGH-REACTIVITY ISOBUTENE HOMO- OR COPOLYMERS<br/>[FR] PROCÉDÉ DE PRÉPARATION D'HOMOPOLYMÈRES OU DE COPOLYMÈRES D'ISOBUTÈNE HAUTEMENT RÉACTIFS
  申请人：BASF SE

  公开号：WO2017140602A1

  公开（公告）日：2017-08-24

  The present invention relates to a process for preparing high- reactivity isobutene homo- or copolymers with a content of terminal vinylidene double bonds per polyisobutene chain end of at least 70 mol%, which comprises polymerizing isobutene or an isobutene-comprising monomer mixture in the presence of an aluminum trihalide-donor complex effective as a polymerization catalyst or an alkylaluminum halide-donor complex effective as a polymerization catalyst, wherein the aluminum trihalide or alkylaluminum halide is treated with at least one inorganic hydrate.