5-methyl-2-methylsulfanyl-4,5-dihydro-thiazole | 63880-70-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 5-methyl-2-methylsulfanyl-4,5-dihydro-thiazole
• 英文别名: 5-Methyl-2-methylmercapto-4,5-dihydro-thiazol；5-methyl-2-methylthio-2-thiazoline；5-Methyl-2-methylsulfanyl-4,5-dihydro-1,3-thiazole
• CAS: 63880-70-6
• 化学式: C₅H₉NS₂
• 分子量: 147.265
• InChiKey: MFXACDCYMVVPHZ-UHFFFAOYSA-N

物化性质

• 沸点：
  222.1±9.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  63
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-methyl-2-methylsulfanyl-4,5-dihydro-thiazole 在 氯化铵 作用下， 以 乙醇 为溶剂， 生成 5-甲基-4,5-二氢-噻唑-2-基胺
  参考文献：
  名称：

  Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase

  摘要：

  Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.06.033
• 作为产物：
  描述：

  异丙醇胺 生成 5-methyl-2-methylsulfanyl-4,5-dihydro-thiazole
  参考文献：
  名称：

  593.噻唑啉田中的环化，环裂变和酰基迁移反应

  摘要：

  DOI：

  10.1039/jr9520003094

文献信息

• Derivatives of 2-iminothiazolidines and thiazolines
  申请人：Merck & Co., Inc.

  公开号：US04181661A1

  公开（公告）日：1980-01-01

  2-(Substituted imino)thiazolidines and thiazolines are inhibitors of indoleamine-N-methyl transferase in vivo. They are prepared by alkylation or acylation of the free imino group.

  (取代基亚胺基)噻唑烷和噻唑烯是体内吲哚胺-N-甲基转移酶的抑制剂。它们通过对游离亚胺基进行烷基化或酰化而制备。
• Method of treatment with 2-iminothiazolidines and thiazolines
  申请人：Merck & Co., Inc.

  公开号：US04029803A1

  公开（公告）日：1977-06-14

  A method of inhibiting indoleamine-N-methyl transferase comprises the administration to a host of a therapeutically effective amount of a 3-hydrocarbyl-2-imino-thiazolidine or thiazoline or a pharmaceutically acceptable salt thereof.

  一种抑制吲哚胺-N-甲基转移酶的方法，包括向宿主给予3-羟基烷基-2-亚氨基噻唑啉或噻唑环或其药学上可接受的盐的治疗有效量。
• Cyclic amidine inhibitors of indolamine N-methyltransferase
  作者：Joshua Rokach、Pierre Hamel、Norman R. Hunter、Grant Reader、Clarence S. Rooney、Paul S. Anderson、Edward J. Cragoe、Lewis R. Mandel

  DOI：10.1021/jm00189a004

  日期：1979.3

  Syntheses of a large number of mono- and bicyclic, as well as a few tricyclic, amidine derivatives related to 2,3,4,6,7,8,-hexahydropyrrolo[1,2-a]pyrimidine (DBN) are reported. In vitro potencies for inhibition of the enzyme indolamine N-methyltransferase (INMT) from rabbit and human lung are presented. Four bicyclic amidine derivatives and 11 monocyclic derivatives were found to be equal or superior to DBN in in vitro potencies. With the bicyclic amidines, increasing ring size or introduction of substituents reduced activity. Among the monocyclic analogues, the most potent representatives were five- or six-membered systems with an exocyclic imino group, combined with methyl of ethyl substituents on the endocyclic nitrogen. Introduction of additonal substituents decreased inhibitory potency. 2,3,5,6-Tetrahydro-8H-imidazo[2,1-c][1,4]thiazine and 3-methyl-2-iminothiazolidine have been shown to cause inhibition of lung INMT when administered orally to rabbits.
• Laduranty; Barbot; Miginiac, Canadian Journal of Chemistry, 1987, vol. 65, # 4, p. 859 - 867
  作者：Laduranty、Barbot、Miginiac

  DOI：——

  日期：——
• Amino Acids. VII. N,N'-Di-(ι-carboxyalkylthiocarbamyl)- and N,N'-Di-(ι-carboxyalkylcarbamyl)-polymethylenediamines and their Derivatives
  作者：A. F. McKay、S. Gelblum、E. J. Tarlton、P. R. Steyermark、M. A. Mosley

  DOI：10.1021/ja01546a036

  日期：1958.7