4-苯基-4-乙氧甲酰哌啶盐酸盐 | 24465-45-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 4-苯基-4-乙氧甲酰哌啶盐酸盐
• 中文别名: 4-苯基哌啶-4-甲酸乙酯盐酸盐
• 英文名称: ethyl 4-phenyl-4-piperidinecarboxylate hydrochloride
• 英文别名: normeperidine hydrochloride；ethyl 4-phenyl-4-piperidinecarboxylate HCl；4-phenyl-piperidine-4-carboxylic acid ethyl ester; hydrochloride；4-Phenyl-piperidin-4-carbonsaeure-aethylester; Hydrochlorid；ethyl 4-phenylpiperidine-4-carboxylate hydrochloride；4-Phenyl-piperidine-4-carboxylic acid ethyl ester hydrochloride；ethyl 4-phenylpiperidine-4-carboxylate;hydrochloride
• CAS: 24465-45-0
• 化学式: C₁₄H₁₉NO₂*ClH
• 分子量: 269.771
• InChiKey: BBWMASBANDIFMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.07
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  42.9
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 储存条件：
  -20°C，密闭保存，干燥环境

制备方法与用途

Norepinephrine hydrochloride is a certified reference material classified as an opioid in terms of its structure.

反应信息

• 作为反应物：
  描述：

  4-苯基-4-乙氧甲酰哌啶盐酸盐 在 乙醇 、 sodium carbonate 、 铂 、 正丁醇 作用下， 生成 1-[3-(4-amino-phenyl)-propyl]-4-phenyl-piperidine-4-carboxylic acid ethyl ester
  参考文献：
  名称：

  Strong Analgesics. The Preparation of Some Ethyl 1-Aralkyl-4-phenylpiperidine-4-carboxylates¹

  摘要：

  DOI：

  10.1021/ja01565a050
• 作为产物：
  描述：

  4-氰基-4-苯基哌嗪 在 硫酸 作用下， 以 乙醇 、 水 为溶剂， 生成 4-苯基-4-乙氧甲酰哌啶盐酸盐
  参考文献：
  名称：

  Dipeptides which promote release of growth hormone

  摘要：

  式(I)的化合物是生长激素释放肽类似物，对于治疗和预防骨质疏松症很有用。

  公开号：

  US05936089A1

文献信息

• Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors
  作者：Lorraine C. Axford、Piyush K. Agarwal、Kelly H. Anderson、Laura N. Andrau、John Atherall、Stephanie Barker、James M. Bennett、Michael Blair、Ian Collins、Lloyd G. Czaplewski、David T. Davies、Carlie T. Gannon、Dushyant Kumar、Paul Lancett、Alastair Logan、Christopher J. Lunniss、Dale R. Mitchell、Daniel A. Offermann、James T. Palmer、Nicholas Palmer、Gary R.W. Pitt、Stéphanie Pommier、Daniel Price、B. Narasinga Rao、Rashmi Saxena、Tarun Shukla、Amit K. Singh、Mahipal Singh、Anil Srivastava、Christopher Steele、Neil R. Stokes、Helena B. Thomaides-Brears、Edward M. Tyndall、David Watson、David J. Haydon

  DOI：10.1016/j.bmcl.2013.10.058

  日期：2013.12

  The discovery and optimisation of a new class of benzothiazole small molecules that inhibit bacterial DNA gyrase and topoisomerase IV are described. Antibacterial properties have been demonstrated by activity against DNA gyrase ATPase and potent activity against Staphylococcus aureus, Enterococcus faecalis, Streptococcus pyogenes and Haemophilus influenzae. Further refinements to the scaffold designed

  描述和优化抑制细菌DNA促旋酶和拓扑异构酶IV的新型苯并噻唑小分子的发现和优化。对DNA促旋酶ATPase的活性和对金黄色葡萄球菌，粪肠球菌，化脓性链球菌和流感嗜血杆菌的活性证明了抗菌性能。设计用于增强药物相似性的支架的进一步改进包括带有羧酸基团的α-取代基的类似物，从而产生出色的溶解性和良好的药代动力学特性。
• Substituted piperidines as melanocortin-4 receptor agonists
  申请人：Merck & Co., Inc.

  公开号：US06350760B1

  公开（公告）日：2002-02-26

  Certain novel substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction. Also provided are methods of treating sexual dysfunction with a compound that is a selective agonist of MC-4R over any other human melanocortin receptor.

  某些新型替代哌啶化合物是人类黑色素皮质素受体的激动剂，特别是人类黑色素皮质素-4受体（MC-4R）的选择性激动剂。因此，它们对于治疗、控制或预防对MC-4R激活敏感的疾病和紊乱是有用的，例如肥胖症、糖尿病、性功能障碍，包括勃起功能障碍和女性性功能障碍。还提供了使用对MC-4R具有选择性激动剂的化合物治疗性功能障碍的方法，而不是其他任何人类黑色素皮质素受体。
• 1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives
  申请人：Janssen Pharmaceutica N.V.

  公开号：US04369184A1

  公开（公告）日：1983-01-18

  Novel 1-(cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives, bearing in the 4-position of the cyclohexyl ring a cyano group and an aryl moiety, said compounds displaying useful antihistaminic properties.

  新颖的1-(环己基)-4-芳基-4-哌啶羧酸衍生物，在环己基环的4位带有氰基和芳基基团，这些化合物具有有用的抗组胺性能。
• Gas Chromatographic Analysis of Meperidine and Normeperidine: Determination in Blood after a Single Dose of Meperidine
  作者：Peyton Jacob、Jean F. Rigod、Susan M. Pond、Neal L. Benowitz

  DOI：10.1002/jps.2600710207

  日期：1982.2

  A method is described for the determination of meperidine and its pharmacologically active metabolite, normeperidine, in blood, plasma, and urine using gas chromatography with nitrogen-phosphorus detection. Structural analogs of both meperidine and normeperidine were used as internal standards. Unlike previously reported assays, this procedure was sensitive and convenient enough for use in pharmacokinetic

  描述了一种使用氮磷检测的气相色谱法测定血液，血浆和尿液中甲哌丁啶及其药理活性代谢物诺美哌啶的方法。哌啶和去甲哌啶的结构类似物均用作内标。与以前报道的测定法不同，此程序灵敏且方便，足以用于单次注射哌替啶后的哌替啶和去甲哌啶的药代动力学研究。该测定对从1毫升生物样品中提取的5 ng甲哌啶/ ml和2.5 ng甲哌啶/ ml敏感。在这些浓度下，测定之间的变异系数分别为9.4％和10.4％。
• FMO3 inhibitors for treating pain
  申请人：Akron Molecules GmbH

  公开号：EP2674161A1

  公开（公告）日：2013-12-18

  The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies.

  本发明涉及治疗疼痛和相关疾病的新疗法，以及用于上述疗法的药物化合物。