diglycidyl 2,7-naphthalenedicarboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: diglycidyl 2,7-naphthalenedicarboxylate
• 英文别名: Bis(oxiran-2-ylmethyl) naphthalene-2,7-dicarboxylate
• 化学式: C₁₈H₁₆O₆
• 分子量: 328.321
• InChiKey: JHXXYQXOUONPNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  77.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,7-萘二羧酸二甲酯 、 缩水甘油 在 三十二烷基甲基氯化铵 作用下， 以 正己烷 、 甲苯 为溶剂， 反应 3.0h， 以51%的产率得到diglycidyl 2,7-naphthalenedicarboxylate
  参考文献：
  名称：

  季烷基烷基铵盐催化的甲基酯的酯交换反应将缩水甘油转化为缩水甘油酯

  摘要：

  缩水甘油的催化转化同时保持其环氧化物部分完整是具有挑战性的，因为通过氢键与羟基相互作用的末端环氧化物对于开环反应是不稳定的。我们发现季烷基铵盐通过甲酯的酯交换反应催化缩水甘油缩水合为缩水甘油酯。所开发的方法可用于多缩水甘油酯的合成，多缩水甘油酯是有价值的环氧树脂单体。机理研究表明，在非极性溶剂中缩水甘油与季烷基铵盐的结合络合物的形成，以及通过环氧化物的开环反应生成了作为催化剂的醇盐阴离子。对反应机理的计算研究表明，由缩水甘油产生的醇盐阴离子趋向于提取另一缩水甘油的质子，而不是作为亲核试剂起作用，从而引发了催化酯交换反应。由于阴离子和二醇之间存在双氢键，因此产生质子化的缩水甘油缩水甘油酯的Payne重排会产生不利于能量的不利反应，从而促进非选择性反应。季烷基铵阳离子和环氧化物部分之间的最小相互作用抑制了导致聚合的无规开环途径。由于阴离子和二醇之间的双氢键，在能量上不利。季烷基铵阳离子和环氧化

  DOI：

  10.1021/acscatal.7b03303

文献信息

• CHIP PROVIDED WITH FILM HAVING HOLE PATTERN WITH THE USE OF THERMORESPONSIVE POLYMER AND METHOD OF PRODUCING THE SAME
  申请人：Toyama Prefecture

  公开号：EP1942179A1

  公开（公告）日：2008-07-09

  [PROBLEMS] To provide a novel chip useful for tretaing cells and the like which has a mechanism and a structure wherein the size of a hole pattern is arbitrarily changed so that cells can easily move in and get out from the hole in scattering or collecting cells but can hardly get out from the hole during washing or antigen-stimulation. [MEANS FOR SOLVING PROBLEMS A chip comprising a crosslinked product of a temperature-responsive polymer as a constituting member and being provided with a film having a hole pattern on the surface of a baseboard. A method of producing a chip which comprises a crosslinked product of a temperature-responsive polymer as a constituting member and is provided with a film having a hole pattern on the surface of the baseboard. This method comprises applying a composition containing a crosslinkable temperature-responsive polymer, a composition containing a crosslinkable temperature-responsive polymer and a crosslinking agent or a composition containing a temperature-responsive polymer and a crosslinking agent on the surface of a baseboard to thereby form a coating film, crosslinking the coating film to thereby form the crosslinked product as described above and then forming a hole pattern on the coating film of the crosslinked product.

  [问题] 提供一种用于收集细胞和类似物的新型芯片，它具有一种机制和结构，其中孔图案 的大小可任意改变，以便细胞在散射或收集细胞时容易移入和移出孔，但在洗涤或抗原激 活时几乎不能从孔中移出。[解决问题的方法 一种芯片，它由温度响应聚合物的交联产物作为构成部件，并在底板表面上设有具有孔图案的薄膜。一种生产芯片的方法，该芯片由温度响应性聚合物的交联产物作为构成成分，并在底板表面上附有一层具有孔图案的薄膜。该方法包括在基板表面涂敷含有可交联温度响应性聚合物的组合物、含有可交联温度响应性聚合物和交联剂的组合物或含有温度响应性聚合物和交联剂的组合物，从而形成涂膜，使涂膜交联从而形成上述交联产物，然后在交联产物的涂膜上形成孔图案。
• Chip Provided with film Having Hole Pattern with the Use of Thermoresponsive Polymer and Method of Producing the Same
  申请人：Tamiya Eiichi

  公开号：US20090130384A1

  公开（公告）日：2009-05-21

  [Problems] To provide a novel chip useful for treating cells and the like which has a mechanism and a structure wherein the size of a hole pattern is arbitrarily changed so that cells can easily move in and get out from the hole in scattering or collecting cells but can hardly get out from the hole during washing or antigen-stimulation. [Means for Solving Problems] A chip comprising a crosslinked product of a temperature-responsive polymer as a constituting member and being provided with a film having a hole pattern on the surface of a baseboard. A method of producing a chip which comprises a crosslinked product of a temperature-responsive polymer as a constituting member and is provided with a film having a hole pattern on the surface of the baseboard. This method comprises applying a composition containing a crosslinkable temperature-responsive polymer, a composition containing a crosslinkable temperature-responsive polymer and a crosslinking agent or a composition containing a temperature-responsive polymer and a crosslinking agent on the surface of a baseboard to thereby form a coating film, crosslinking the coating film to thereby form the crosslinked product as described above and then forming a hole pattern on the coating film of the crosslinked product.
• US8664003B2
  申请人：——

  公开号：US8664003B2

  公开（公告）日：2014-03-04
• Quaternary Alkyl Ammonium Salt-Catalyzed Transformation of Glycidol to Glycidyl Esters by Transesterification of Methyl Esters
  作者：Shinji Tanaka、Takuya Nakashima、Toshie Maeda、Manussada Ratanasak、Jun-ya Hasegawa、Yoshihiro Kon、Masanori Tamura、Kazuhiko Sato

  DOI：10.1021/acscatal.7b03303

  日期：2018.2.2

  ring-opening reaction of the epoxide. Computational studies of the reaction mechanism indicated that the alkoxide anion derived from glycidol tends to abstract the proton of another glycidol rather than work as a nucleophile, initiating the catalytic transesterification. Payne rearrangement of the deprotonated glycidol, which produces a destabilized base that promotes nonselective reactions, is energetically

  缩水甘油的催化转化同时保持其环氧化物部分完整是具有挑战性的，因为通过氢键与羟基相互作用的末端环氧化物对于开环反应是不稳定的。我们发现季烷基铵盐通过甲酯的酯交换反应催化缩水甘油缩水合为缩水甘油酯。所开发的方法可用于多缩水甘油酯的合成，多缩水甘油酯是有价值的环氧树脂单体。机理研究表明，在非极性溶剂中缩水甘油与季烷基铵盐的结合络合物的形成，以及通过环氧化物的开环反应生成了作为催化剂的醇盐阴离子。对反应机理的计算研究表明，由缩水甘油产生的醇盐阴离子趋向于提取另一缩水甘油的质子，而不是作为亲核试剂起作用，从而引发了催化酯交换反应。由于阴离子和二醇之间存在双氢键，因此产生质子化的缩水甘油缩水甘油酯的Payne重排会产生不利于能量的不利反应，从而促进非选择性反应。季烷基铵阳离子和环氧化物部分之间的最小相互作用抑制了导致聚合的无规开环途径。由于阴离子和二醇之间的双氢键，在能量上不利。季烷基铵阳离子和环氧化