4-[[4-(二甲氨基)苯基]-(4-甲基苯基)甲基]-N,N-二甲基苯胺 | 641-58-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 中文名称: 4-[[4-(二甲氨基)苯基]-(4-甲基苯基)甲基]-N,N-二甲基苯胺
• 英文名称: 4,4'-[(4-methylphenyl)methylene]bis(N,N-dimethylaniline)
• 英文别名: 4,4'-(p-tolylmethylene)-bis-(N,N-dimethylaniline)；bis-(4-dimethylamino-phenyl)-p-tolyl-methane；Bis-(4-dimethylamino-phenyl)-p-tolyl-methan；p-Methyl-leukomalachitgruen；4'.4''-Bis-dimethylamino-4-methyl-triphenylmethan；4-[[4-(dimethylamino)phenyl]-(4-methylphenyl)methyl]-N,N-dimethylaniline
• CAS: 641-58-7
• 化学式: C₂₄H₂₈N₂
• 分子量: 344.5
• InChiKey: SUYRYQPXJMNDTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-[[4-(二甲氨基)苯基]-(4-甲基苯基)甲基]-N,N-二甲基苯胺 在 硫酸 作用下， 生成 5-(4,4'-bis-dimethylamino-benzhydryl)-2-methyl-benzenesulfonic acid
  参考文献：
  名称：

  Noelting; Gerlinger, Chemische Berichte, 1906, vol. 39, p. 2053

  摘要：

  DOI：
• 作为产物：
  描述：

  对甲基苯甲醛 、 N,N-二甲基苯胺 在 N,N-dimethylformamidium hydrogen sulfate 作用下， 以 neat (no solvent) 为溶剂， 反应 3.0h， 以79%的产率得到4-[[4-(二甲氨基)苯基]-(4-甲基苯基)甲基]-N,N-二甲基苯胺
  参考文献：
  名称：

  AIL离子液体催化合成对称的三芳基甲烷衍生物

  摘要：

  摘要描述了一种有效的，生态友好的离子液体，用于通过酰胺离子液体作为催化剂，通过N，N-二甲基苯胺与不同的活性芳香醛化合物的Baeyer缩合反应合成对称的三芳基甲烷衍生物。首次使用酰胺离子液体作为催化剂完成了合成，消除了对挥发性有机溶剂的需求。该离子液体的优点是低成本和操作简单。 图形概要

  DOI：

  10.1007/s00706-017-2053-2

文献信息

• Halogen-Free Room-Temperature Brønsted Acidic Ionic Liquid [Hmim]⁺ HSO₄ ⁻ as a Recyclable Green “Dual Reagent” Catalysis for the Synthesis of Triarylmethanes (TRAM<scp>s</scp>)
  作者：Chhanda Mukhopadhyay、Arup Datta、Pradip Kumar Tapaswi

  DOI：10.1080/00397911.2011.560742

  日期：2012.8.15

  halogen-free Brønsted acidic ionic liquid methylimidazolium hydrogen sulfate ([Hmim]+ HSO4 −) acts as a very efficient catalyst for the one-pot, two-component Baeyer condensation of a variety of aromatic aldehydes with dimethyl or diethyl aniline at room temperature. This “green” reagent behaves as both catalyst and solvent; that is, it exhibits “dual-reagent catalysis.” The room-temperature acidic ionic liquid

  摘要 无卤 Brønsted 酸性离子液体硫酸氢甲基咪唑鎓 ([Hmim]+ HSO4 -) 是一种非常有效的催化剂，可用于多种芳香醛与二甲基或二乙基苯胺在室温下的一锅双组分拜耳缩合反应。温度。这种“绿色”试剂既是催化剂又是溶剂；也就是说，它表现出“双试剂催化作用”。室温酸性离子液体可以循环多次，反应收率几乎没有损失。这是 Baeyer 合成无卤离子液体的首次报道。图形概要
• Malachite Green Derivatives for Two-Photon RNA Detection
  作者：Jacques Lux、Eduardo José Peña、Frédéric Bolze、Manfred Heinlein、Jean-François Nicoud

  DOI：10.1002/cbic.201100747

  日期：2012.5.29

  A library of malachite green derivatives was designed in order to improve two‐photon detection of a malachite green RNA aptamer. Some of the prepared derivatives show remarkable affinity for the aptamer and improved two‐photon brightness as measured by two‐photon fluorescence correlation spectroscopy. These new derivatives show lower toxicity than the classical malachite green oxalate.

  设计了孔雀石绿色衍生物库，以改善孔雀石绿色RNA适体的双光子检测。通过双光子荧光相关光谱法测得，某些制备的衍生物对适体具有显着的亲和力，并改善了双光子亮度。这些新的衍生物显示出比传统的孔雀石绿草酸盐更低的毒性。
• Synthesis, Characterization and Application of N,N-Dimethyl-N-Sulfoethan Ammonium tetra-Chloro Aluminate: A Novel micro-Heterogeneous Cata-lyst for Synthesis of tri-Arylmethanes
  作者：Saeid Azimi、Niloofar Mohamadighader

  DOI：10.2174/1570178617999200925205313

  日期：2020.9.25

  liquid and heterogenised by changing the anion reaction. The new heterogeneous acidic catalyst was characterized by SEM images, EDS analysis, AFM images, Ft-IR, HNMR, 13CNMR and Mass Spectroscopy. It was applied to the synthesis of tri-arylmethanes throughout one-pot tri-component reactions among aromatic aldehydes, N,N-dimethylaniline and other carbonic nucleophiles such as anisole and indole. Hence, the

  一种新的固体催化剂由离子液体合成，并通过改变阴离子反应进行异质化。通过SEM图像、EDS分析、AFM图像、Ft-IR、HNMR、13 CNMR和质谱对新型多相酸性催化剂进行表征。它被应用于芳醛、N,N-二甲基苯胺和其他含碳亲核试剂（如苯甲醚和吲哚）之间的一锅三组分反应中合成三芳基甲烷。因此，引入了方便且廉价的微多相催化剂的合成，其效率得到了证实。此外，在这个简单而干净的过程中合成了各种有用的产品。
• SbCl₃-catalyzed one-pot synthesis of 4,4′-diaminotriarylmethanes under solvent-free conditions: Synthesis, characterization, and DFT studies
  作者：Ghasem Rezanejade Bardajee

  DOI：10.3762/bjoc.7.19

  日期：——

  A simple, efficient, and mild procedure for a solvent-free one-step synthesis of various 4,4′-diaminotriarylmethane derivatives in the presence of antimony trichloride as catalyst is described. Triarylmethane derivatives were prepared in good to excellent yields and characterized by elemental analysis, FTIR, ¹H and ¹³C NMR spectroscopic techniques. The structural and vibrational analysis were investigated by performing theoretical calculations at the HF and DFT levels of theory by standard 6-31G*, 6-31G*/B3LYP, and B3LYP/cc-pVDZ methods and good agreement was obtained between experimental and theoretical results.

  本文介绍了一种简单、高效、温和的无溶剂单步合成各种4,4'-二氨基三芳基甲烷衍生物的方法，该方法以三氯化锑为催化剂。三芳基甲烷衍生物的产率良好至优良，并通过元素分析、傅里叶变换红外光谱、¹H和¹³C NMR光谱技术进行了表征。通过标准6-31G*、6-31G*/B3LYP和B3LYP/cc-pVDZ方法进行理论计算，研究了结构和振动分析，并获得了实验和理论结果之间的良好一致性。
• MULTI-USE MULTIMODAL IMAGING CHELATES
  申请人：Bornhop Darryl J.

  公开号：US20080241873A1

  公开（公告）日：2008-10-02

  Cyclen-based chelates can be used as contrast agents for multi-modal imaging of tissue cells. The cyclen-based chelates are preferably polyazamacrocyclic molecules formed from 1,4,7,10 tetraazacyclododecane (“cyclen”) having varying chelating ions, phosphoester chains, and light harvesting moieties. By changing the chelating ion, phosphoester chain length and/or the light harvesting moiety different imaging techniques, such as MRI, CT, fluorescence and absorption, x-ray and NIR, may be employed to image the tissue cells. Additionally, the cyclen-based chelates may be conjugated to provide for site-specific delivery of the cyclen-based chelate to the desired tissue cells. The cyclen-based chelates may also be delivered to the tissue cells by attaching the cyclen-based to a polymeric delivery vehicle. Although these cyclen-based chelates have a wide variety of application, the preferred use is for imaging of cancer cells, such as brain cancer, for improving resection of a cancerous tissue.

  基于环丙氮（Cyclen）的螯合剂可用作多模态组织细胞成像的对比剂。这些基于环丙氮的螯合剂最好是由1,4,7,10-四氮杂环十二烷（“Cyclen”）形成的多氮杂大环分子，具有不同的螯合离子、磷酸酯链和光收集基团。通过改变螯合离子、磷酸酯链长度和/或光收集基团，可以使用不同的成像技术，如MRI、CT、荧光和吸收、X射线和近红外线来成像组织细胞。此外，可以将基于环丙氮的螯合剂共价结合，以实现对所需组织细胞的位点特异性递送。也可以通过将基于环丙氮的螯合剂连接到聚合物递送载体上来将其递送到组织细胞中。尽管这些基于环丙氮的螯合剂有广泛的应用，但首选用途是用于癌细胞成像，如脑癌，以改善癌组织切除。