cyclopropylmethoxytrimethylsilane | 85696-54-4

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: cyclopropylmethoxytrimethylsilane
• 英文别名: (cyclopropylmethoxy)trimethylsilane；Silane, (cyclopropylmethoxy)trimethyl-；cyclopropylmethoxy(trimethyl)silane
• CAS: 85696-54-4
• 化学式: C₇H₁₆OSi
• 分子量: 144.289
• InChiKey: UHNNKGHEOUDWJJ-UHFFFAOYSA-N

物化性质

• 沸点：
  166.0±8.0 °C(Predicted)
• 密度：
  0.869±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.25
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  cyclopropylmethoxytrimethylsilane 在 Wilkinson's catalyst 氢气 作用下， 以 甲苯 为溶剂， 130.0 ℃ 、405.33 kPa 条件下， 反应 18.0h， 生成 (异丙基甲氧基)三甲基硅烷
  参考文献：
  名称：

  Selective, Catalytic Carbon−Carbon Bond Activation and Functionalization Promoted by Late Transition Metal Catalysts

  摘要：

  The selective catalytic activation and functionalization of carbon-carbon bonds in a series of substituted cyclopropane substrates has been developed using commercially available transition metal catalysts. Catalytic hydrogenation and olefination procedures, tolerant of a range of functional groups, have been discovered. Introduction of a chelate-assisting substituent such as [PPh2] is effective in altering the kinetic selectivity and lowering the activation barrier for the catalytic processes.

  DOI：

  10.1021/ja028912j
• 作为产物：
  描述：

  羟甲基环丙烷 生成 cyclopropylmethoxytrimethylsilane
  参考文献：
  名称：

  Synthesis of diosphenol ethers by means of alkoxytrimethylsilanes

  摘要：

  DOI：

  10.1016/s0040-4039(00)85105-9

文献信息

• [EN] HETEROCYCLIC INHIBITORS OF BETA - SECRETASE FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES<br/>[FR] INHIBITEURS HÉTÉROCYCLIQUES DE LA BÊTA-SECRÉTASE POUR LE TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2012071458A1

  公开（公告）日：2012-05-31

  The invention provides novel tricyclic compounds of Formula I' that inhibit β-secretase cleavage of APP and are useful as therapeutic agents for treating neurodegenerative diseases.

  本发明提供了一种抑制β-分泌酶裂解APP的新颖三环化合物，式I'，可用作治疗神经退行性疾病的治疗剂。
• COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES
  申请人：Cook Adam

  公开号：US20120157448A1

  公开（公告）日：2012-06-21

  The invention provides novel tricyclic compounds of Formula I′ that inhibit β-secretase cleavage of APP and are useful as therapeutic agents for treating neurodegenerative diseases.

  该发明提供了一种新型三环化合物I'的公式，它能够抑制β-分泌酶对APP的剪切，并且可用作治疗神经退行性疾病的治疗剂。
• The influence of α-trialkylsilyloxy groups on the rate of ring opening of cyclopropylmethyl radicals
  作者：D.C. Nonhebel、C.J. Suckling、J.C. Walton

  DOI：10.1016/s0040-4039(00)85632-4

  日期：1982.1

  The rate of ring opening of α-trialkylsilyloxycyclopropylmethyl radicals is about ten times slower than of the cyclopropylmethyl radical at 298K.

  α-三烷基甲硅烷基氧基环丙基甲基的开环速率比在298K下环丙基甲基的开环速率慢约十倍。
• PONARAS A. A.; MEAH MD. YOUNUS, TETRAHEDRON LETT., 27,(1986) N 41, 4953-4956
  作者：PONARAS A. A.、 MEAH MD. YOUNUS

  DOI：——

  日期：——
• Selective, Catalytic Carbon−Carbon Bond Activation and Functionalization Promoted by Late Transition Metal Catalysts
  作者：Suzanne C. Bart、Paul J. Chirik

  DOI：10.1021/ja028912j

  日期：2003.1.1

  The selective catalytic activation and functionalization of carbon-carbon bonds in a series of substituted cyclopropane substrates has been developed using commercially available transition metal catalysts. Catalytic hydrogenation and olefination procedures, tolerant of a range of functional groups, have been discovered. Introduction of a chelate-assisting substituent such as [PPh2] is effective in altering the kinetic selectivity and lowering the activation barrier for the catalytic processes.