2-ethyl-2-aza-bicyclo[3.3.1]nonane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-ethyl-2-aza-bicyclo[3.3.1]nonane
• 英文别名: 2-Aethyl-2-aza-bicyclo[3.3.1]nonan；2-ethyl-2-azabicyclo[3.3.1]nonane
• 化学式: C₁₀H₁₉N
• 分子量: 153.268
• InChiKey: AMTGNAJIJPERJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 copper oxide-chromium oxide 、 叔丁醇 作用下， 250.0 ℃ 、29.42 MPa 条件下， 生成 2-ethyl-2-aza-bicyclo[3.3.1]nonane
  参考文献：
  名称：

  AZABICYCLOALKANES. 2-AZABICYCLO[3·3·1]NONANE^1,2

  摘要：

  DOI：

  10.1021/jo01158a009

文献信息

• DIHYDROPTERIDINONE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF
  申请人：Tang Peng Cho

  公开号：US20120184543A1

  公开（公告）日：2012-07-19

  Dihydroperidinone derivatives, preparation process and pharmaceutical use thereof are disclosed. Specially, new dihydroperidinone derivatives represented by general formula (I), wherein each substituent of the general formula (I) is defined as in the description, their preparation process, pharmaceutical compositions comprising said derivatives and their use as therapeutical agents, especially as Plk kinase inhibitors are disclosed.

  二氢吡啶酮衍生物、其制备方法及药用途被揭示。特别是，根据通用式(I)表示的新二氢吡啶酮衍生物，其中通用式(I)的每个取代基如描述中所定义，它们的制备过程，包含所述衍生物的药物组合物以及它们作为治疗剂的用途，特别是作为Plk激酶抑制剂的用途被揭示。
• 6-AMINO QUINAZOLINE OR 3-CYANO QUINOLINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF
  申请人：Tang Peng Cho

  公开号：US20120165352A1

  公开（公告）日：2012-06-28

  6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof are disclosed. Specifically, the present disclosure discloses novel 6-amino quinazoline or 3-cyano quinoline derivatives presented by general formula (I), or tautomers, enantiomers, diastereomers, racemates or pharmaceutically acceptable salts thereof, or metabolites, metabolic precursors or prodrugs thereof, and their uses as treatment agents especially as protein kinase inhibitors, in which each substitutent group of general formula (I) is as defined in the specification.

  本文揭示了6-氨基喹唑啉或3-氰基喹啉衍生物的制备方法和药用。具体来说，本公开揭示了一般式(I)所示的新型6-氨基喹唑啉或3-氰基喹啉衍生物，或其互变体、对映体、非对映异构体、消旋体或其药学上可接受的盐，或其代谢物、代谢前体或前药，以及它们作为治疗剂的用途，特别是作为蛋白激酶抑制剂，其中一般式(I)的每个取代基如规范中所定义。
• Morphan derivatives or salts thereof and medicinal compositions containing the same
  申请人：Hisamitsu Pharmaceutical Co., Ltd.

  公开号：US06608080B1

  公开（公告）日：2003-08-19

  Medicinal compositions having an effect of regulating the activation of glycine receptor and novel morphan derivatives. Medicinal compositions comprising morphan derivatives or its salts and a pharmaceutically acceptable carrier. These compositions potentiate or inhibit the activation of glycine receptor, which makes them useful as drugs for the central nervous system. Novel 1- and/or 2-substituted morphan derivatives (2-azabicyclo[3.3.1]nonane derivatives) or salts thereof.

  具有调节甘氨酸受体激活作用的药物组合物和新型吗啡衍生物。药物组合物包括吗啡衍生物或其盐和药学上可接受的载体。这些组合物能够增强或抑制甘氨酸受体的激活，因此它们可用作中枢神经系统药物。新型1-和/或2-取代吗啡衍生物（2-氮杂双环[3.3.1]壬烷衍生物）或其盐。
• MORPHAN DERIVATIVES OR SALTS THEREOF AND MEDICINAL COMPOSITIONS CONTAINING THE SAME
  申请人：HISAMITSU PHARMACEUTICAL CO. INC.

  公开号：EP1167353A1

  公开（公告）日：2002-01-02

  Medicinal compositions having an effect of regulating the activation of glycine receptor and novel morphan derivatives. Medicinal compositions comprising morphan derivatives or its salts and a pharmaceutically acceptable carrier. These compositions potentiate or inhibit the activation of glycine receptor, which makes them useful as drugs for the central nervous system. Novel 1- and/or 2-substituted morphan derivatives (2-azabicyclo[3.3.1]nonane derivatives) or salts thereof.

  具有调节甘氨酸受体活化作用的药物组合物和新型吗啡烷衍生物。药用组合物包含吗啡烷衍生物或其盐类以及药学上可接受的载体。这些组合物能增强或抑制甘氨酸受体的活化，因此可作为中枢神经系统的药物。新型 1-和/或 2-取代吗啡衍生物（2-氮杂双环[3.3.1]壬烷衍生物）或其盐。
• AZABICYCLO-SUBSTITUTED TRIAZOLE DERIVATIVE, PREPARATION METHOD THEREOF, AND APPLICATION OF SAME IN MEDICINE
  申请人：Jiangsu Hengrui Medicine Co., Ltd.

  公开号：EP3564231A1

  公开（公告）日：2019-11-06

  The present invention relates to an azabicyclo-substituted triazole derivative, a preparation method thereof, and an application of the same in medicine. In particular, the present invention relates to a novel azabicyclo-substituted triazole derivative represented by general formula (I), a preparation method thereof, a pharmaceutical composition containing the derivative, a use thereof as a therapeutic agent, especially as an oxytocin antagonist, and a use of the same in preparing a drug for treating or preventing a disease or disorder known or shown to have beneficial effect thereon with oxytocin being suppressed. The definition of each substituent in the general formula (I) is the same as the definition in the specification.

  本发明涉及一种氮杂双环取代三唑衍生物、其制备方法及其在医药中的应用。特别是，本发明涉及一种由通式（I）表示的新型氮杂双环取代三唑衍生物、其制备方法、含有该衍生物的药物组合物、其作为治疗剂的用途，特别是作为催产素拮抗剂的用途，以及其在制备用于治疗或预防已知或显示对催产素被抑制的疾病或紊乱具有有益影响的药物中的用途。通式（I）中各取代基的定义与说明书中的定义相同。