3-Trifluoromethylphthalic Anhydride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 3-Trifluoromethylphthalic Anhydride
• 英文别名: 4-(trifluoromethyl)-2-benzofuran-1,3-dione
• 化学式: C₉H₃F₃O₃
• 分子量: 216.116
• InChiKey: QJBYSDFYFHNZHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-trichloromethylphthalic anhydride 、 三氟化锑 以 苯 为溶剂， 生成 3-Trifluoromethylphthalic Anhydride
  参考文献：
  名称：

  Phthalimide derivatives and their use as plant growth regulants

  摘要：

  这项发明是一类新型的邻苯二甲酰亚胺衍生物，其化学式表示为：其中W为氢或烷基C.sub.1 -C.sub.4；X和X'分别表示氢、卤素、烷基C.sub.1 -C.sub.4、CF.sub.3、烷氧基(C.sub.1 -C.sub.4)、苄氧基、二(C.sub.1 -C.sub.4)烷基氨基、烷基硫氧基、羟基、烷基磺酰基、烷酰氨基C.sub.1 -C.sub.4或硝基；Y为--COOR.sub.3、--CONHR.sub.8、--CONR.sub.3 R.sub.4、--CONHN(R.sub.5).sub.2、--CONHN.sup.+(R.sub.6).sub.3 . 卤化物.sup.-、--CN或--COR.sub.7，但X和X'至少有一个是氢以外的取代基；R.sub.1和R.sub.2分别表示烷基C.sub.1 -C.sub.4或与其连接的碳原子形成环烷基C.sub.4 -C.sub.11，可选择地用甲基取代；R.sub.3和R.sub.4分别表示氢或烷基C.sub.1 -C.sub.4；R.sub.5和R.sub.6分别表示烷基C.sub.1 -C.sub.2；R.sub.7为卤素，R.sub.8为--CH.sub.3或其中Z和Z'为氢、烷基C.sub.1 -C.sub.2、卤素、--CF.sub.3或--OCH.sub.3，是一个单键或双键，但环中只能有0或1个双键，并且提供了一种用这些化合物和具有上述结构的化合物调节植物生长的方法，其中X和X'分别表示氢。

  公开号：

  US03940419A1

文献信息

• [EN] N-SUBSTITUTED-5-SUBSTITUTED PHTHALAMIC ACIDS AS SORTILIN INHIBITORS<br/>[FR] ACIDES PHTALAMIQUES N-SUBSTITUÉS-5-SUBSTITUÉS UTILISÉS EN TANT QU'INHIBITEURS DE LA SORTILINE
  申请人：LUNDBECK & CO AS H

  公开号：WO2014114779A1

  公开（公告）日：2014-07-31

  The present invention is directed to N-substituted-5-substituted phthalamic acids which of formula (A). The compounds are considered useful for the treatment of diseases treatment of a neurodegenerative disease, psychiatric disease, motorneuron disease, peripheral neuropathies, pain, neuroinflammation or atherosclerosis such as Alzheimer's disease and Parkinson's disease.

  本发明涉及公式（A）的N-取代-5-取代邻苯二甲酰胺酸。这些化合物被认为对治疗神经退行性疾病、精神疾病、运动神经元疾病、外周神经病、疼痛、神经炎症或动脉粥样硬化等疾病的治疗有用，如阿尔茨海默病和帕金森病。
• N-SUBSTITUTED-5-SUBSTITUTED PHTHALAMIC ACIDS AS SORTILIN INHIBITORS
  申请人：H. Lundbeck A/S

  公开号：US20150368231A1

  公开（公告）日：2015-12-24

  The present invention is directed to N-substituted-5-substituted phthalamic acids which of formula (A). The compounds are considered useful for the treatment of diseases treatment of a neurodegenerative disease, psychiatric disease, motorneuron disease, peripheral neuropathies, pain, neuroinflammation or atherosclerosis such as Alzheimer's disease and Parkinson's disease.

  本发明涉及式(A)的N-取代-5-取代邻苯二甲酸衍生物。这些化合物被认为对治疗神经退行性疾病、精神疾病、运动神经元疾病、周围神经病、疼痛、神经炎症或动脉粥样硬化疾病如阿尔茨海默病和帕金森病具有用处。
• N-substituted-5-substituted phthalamic acids as sortilin inhibitors
  申请人：H. Lundbeck A/S

  公开号：US10195186B2

  公开（公告）日：2019-02-05

  The present invention is directed to N-substituted-5-substituted phthalamic acids which of formula (A). The compounds are considered useful for the treatment of diseases treatment of a neurodegenerative disease, psychiatric disease, motoneuron disease, peripheral neuropathies, pain, neuroinflammation or atherosclerosis such as Alzheimer's disease and Parkinson's disease.

  本发明涉及式（A）的 N-取代-5-取代酞胺酸。 这些化合物可用于治疗神经退行性疾病、精神疾病、运动神经元疾病、周围神经病、疼痛、神经炎症或动脉粥样硬化等疾病，如阿尔茨海默氏症和帕金森氏症。
• Phthalazinone compound, method for preparation thereof, pharmaceutical composition thereof, and use thereof
  申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

  公开号：US11040952B2

  公开（公告）日：2021-06-22

  Provided are a phthalazinone compound, method for preparation thereof, pharmaceutical composition thereof, and a use thereof; the structure of said phthalazinone compound is as represented by formula I; the compound of said formula I is targeted to a viral nucleocapsid; it can inhibit the replication of a virus by means of interference of the viral nucleocapsid, has a potent activity for inhibiting HBV DNA replication and a good liver targeting, can stably exist and enrich in the liver, and is a new and effective anti-HBV inhibitor.

  本发明提供了一种酞嗪酮类化合物、其制备方法、其药物组合物及其用途；所述酞嗪酮类化合物的结构如式I所示；所述式I化合物靶向于病毒核壳，通过干扰病毒核壳抑制病毒复制，具有抑制HBV DNA复制的强效活性和良好的肝脏靶向性，可在肝脏中稳定存在和富集，是一种新型有效的抗HBV抑制剂。
• N-Substituted-5-Substituted Phthalamic Acids as Sortilin Inhibitors
  申请人：H. Lundbeck A/S

  公开号：US20170239226A1

  公开（公告）日：2017-08-24

  The present invention is directed to N-substituted-5-substituted phthalamic acids which of formula (A). The compounds are considered useful for the treatment of diseases treatment of a neurodegenerative disease, psychiatric disease, motoneuron disease, peripheral neuropathies, pain, neuroinflammation or atherosclerosis such as Alzheimer's disease and Parkinson's disease.