Dimethyl-peroxydicarbonat | 15411-45-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: Dimethyl-peroxydicarbonat
• 英文别名: Methoxycarbonyloxy methyl carbonate
• CAS: 15411-45-7
• 化学式: C₄H₆O₆
• 分子量: 150.088
• InChiKey: WFUPNMGWVAEEFM-UHFFFAOYSA-N

物化性质

• 沸点：
  191.59°C (rough estimate)
• 密度：
  1.4076 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

安全信息

• 安全说明：
  PEROXIDES,

反应信息

• 作为反应物：
  描述：

  Dimethyl-peroxydicarbonat 生成 methoxyl radical
  参考文献：
  名称：

  A COMPARATIVE STUDY OF SOME REACTIONS OF THE METHYL AND THE ETHOXY FREE RADICALS IN A GRADED SERIES OF SOLVENTS¹

  摘要：

  DOI：

  10.1021/jo01372a001
• 作为产物：
  描述：

  氯甲酸甲酯 在 sodium peroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 2.0h， 生成 Dimethyl-peroxydicarbonat
  参考文献：
  名称：

  Acyloxylation of 1-Methoxycyclohex-1-ene and Other Enol Ethers with Dimethyl Peroxydicarbonate

  摘要：

  二甲基过氧二碳酸酯 (DPDC) 对不同类型的烯醇醚（来自醛和酮）的酰氧基化反应，结果要么是在双键上加成，要么是以甲氧羰氧基的形式形式上替代了一个烯丙基氢，形成邻位氧化的碳氢化合物。没有观察到通过单酰氧基化形成的1,3-氧代产物。这些结果与铜(I)催化下的1-甲氧基环己-1-烯 (1a) 通过叔丁基过氧羧酸酯 2a, b 进行的酰氧基化反应的结果进行了比较。

  DOI：

  10.1055/s-1995-4026

文献信息

• Effects of oral and transdermal 17β-estradiol with cyclical oral norethindrone acetate on insulin sensitivity, secretion, and elimination in postmenopausal women
  作者：Christopher P. Spencer、Ian F. Godsland、Alison J. Cooper、David Ross、Malcolm I. Whitehead、John C. Stevenson

  DOI：10.1053/meta.2000.6238

  日期：2000.6

  Few studies have examined the effects of 17 beta-estradiol on parameters of insulin and glucose metabolism. We studied 42 healthy, untreated postmenopausal women seeking relief from menopausal symptoms. They were randomized to receive either oral 17 beta-estradiol 2 mg daily combined with sequential oral norethindrone acetate (NETA) 1 mg daily from days 12 to 22, or transdermal 17 beta-estradiol 0.05 mg daily combined with sequential oral NETA 1 mg daily from days 17 to 28. Intravenous glucose tolerance tests (IVGTTs) were performed at baseline and after 48 weeks (estrogen-alone phase) and 48 weeks (combined phase) of completed therapy. Mathematical modeling analysis of plasma glucose, insulin, and C-peptide concentration profiles provided measures of insulin resistance, secretion, and elimination. Both types of therapy were associated with a decrease in fasting insulin and glucose levels. Insulin sensitivity was increased by oral estradiol during the estrogen-alone phase but was reversed by the addition of NETA. Transdermal estradiol did not affect insulin sensitivity. Hepatic insulin uptake and insulin secretion were increased with both types of treatment. The oral regimen of estradiol therapy was favorable to both insulin elimination and sensitivity. Transdermal estradiol therapy had relatively few effects on insulin metabolism. Copyright (C) 2000 by W.B. Saunders Company.
• Kochikina, D. G.; Loginova, N. N.; Kulikova, N. M., Journal of applied chemistry of the USSR, 1983, vol. 56, # 4, p. 902 - 903
  作者：Kochikina, D. G.、Loginova, N. N.、Kulikova, N. M.、Ostrizhko, F. N.、Panshin, Yu. A.

  DOI：——

  日期：——
• Sortieren von Kunststoffen durch thermisch beeinflusste Hafteigenschaften
  作者：Sergej Aman、Jürgen Tomas

  DOI：10.1002/1522-2640(200011)72:11<1382::aid-cite1382>3.0.co;2-y

  日期：2000.11
• Goldschmidt, Angewandte Chemie, 1957, vol. 69, p. 132
  作者：Goldschmidt

  DOI：——

  日期：——
• Acyloxylation of 1-Methoxycyclohex-1-ene and Other Enol Ethers with Dimethyl Peroxydicarbonate
  作者：Kurt Schank、Horst Beck、Susanne Pistorius、Thomas Rapold

  DOI：10.1055/s-1995-4026

  日期：1995.8

  Acyloxylation of different types of enol ethers (derived from aldehydes and ketones) by dimethyl peroxydicarbonate (DPDC) results in either addition to the double bond or in a formal replacement of an allylic hydrogen by a methoxycarbonyloxy group forming vicinal oxygenated hydrocarbons. 1,3-Oxygenated products via monoacyloxylation could not be observed. The results are compared with copper(I)-catalyzed acyloxylations of 1-methoxycyclohex-1-ene (1a) by means of tert-butyl peroxycarboxylates 2a, b.

  二甲基过氧二碳酸酯 (DPDC) 对不同类型的烯醇醚（来自醛和酮）的酰氧基化反应，结果要么是在双键上加成，要么是以甲氧羰氧基的形式形式上替代了一个烯丙基氢，形成邻位氧化的碳氢化合物。没有观察到通过单酰氧基化形成的1,3-氧代产物。这些结果与铜(I)催化下的1-甲氧基环己-1-烯 (1a) 通过叔丁基过氧羧酸酯 2a, b 进行的酰氧基化反应的结果进行了比较。