dibenzyl methyl phosphate | 26292-51-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: dibenzyl methyl phosphate
• 英文别名: phosphoric acid dibenzyl ester-methyl ester；Phosphorsaeure-dibenzylester-methylester；Methyldibenzylphosphat；Dibenzylmethylphosphorate
• CAS: 26292-51-3
• 化学式: C₁₅H₁₇O₄P
• 分子量: 292.271
• InChiKey: DTIQMFGQHQWKBL-UHFFFAOYSA-N

物化性质

• 沸点：
  146 °C(Press: 0.2 Torr)
• 密度：
  1.204±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  dibenzyl methyl phosphate 在 奎宁环 、 草酰氯 作用下， 生成 benzyl methyl chlorophosphate
  参考文献：
  名称：

  从相应的苄基酯方便地“一锅”合成氯代膦酸酯，氯代磷酸酯和氯代磷酰胺

  摘要：

  使用奎尼丁对烷基膦酸酯，磷酸酯和磷酰胺苄基酯进行选择性单脱保护，然后对后续的盐进行氯化，可以方便的“一锅法”制备各种烷基膦酰氯，一氯磷酸酯和一氯磷酰胺。

  DOI：

  10.1016/0040-4039(95)00865-a
• 作为产物：
  描述：

  benzyl methyl N,N-diisopropylphosphoramidite 在 四氮唑 、 次氯酸叔丁酯 作用下， 以 四氯化碳 、 乙腈 为溶剂， 反应 12.5h， 生成 dibenzyl methyl phosphate
  参考文献：
  名称：

  Reactions of benzyl methyl substituted-benzyl phosphites with <i>tert</i>-butyl hypochlorite: "balanced TS" validating reactivity/selectivity principle

  摘要：

  DOI：

  10.1139/cjc-76-6-836

文献信息

• [EN] PRODRUG BIPYRIDYLAMINOPYRIDINES AS SYK INHIBITORS<br/>[FR] PROMÉDICAMENT BIPYRIDYLAMINOPYRIDINES EN TANT QU'INHIBITEURS DE SYK
  申请人：MERCK SHARP & DOHME

  公开号：WO2014074421A1

  公开（公告）日：2014-05-15

  The present invention provides compounds of Formula (I), which are prodrugs of trans-4-[(1R)-(6-[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid, a potent inhibitor of Syk. The compounds are useful in the treatment and prevention of diseases mediated by the enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.

  本发明提供了化合物的公式（I），这些化合物是trans-4-[(1R)-(6-[4-(二氟甲基)吡啶-2-基]氨基}-4-甲基-2,3'-联吡啶-6'-基)-1-羟乙基]环己烷羧酸的前药，是Syk的有效抑制剂。这些化合物在治疗和预防由该酶介导的疾病方面非常有用，如哮喘、慢性阻塞性肺病、类风湿性关节炎和癌症。
• The history of Iberian archaeology: one archaeology for two Spains
  作者：Arturo Ruiz、Alberto Sánchez、Juan P. Bellón

  DOI：10.1017/s0003598x00089973

  日期：2002.3

  Introduction

  In this article we set out to analyse, from an archaeological point of view, a political problem which, as demonstrated by current debate, including acts of violence, goes well beyond archaeology. Throughout the 19th century, and especially in its latter half, a centralist political model for Spain was developed in which a political balance could not be found between the State and [lie autonomous traditions of the varions regions of the Iherian Peninsula. As a result of this failure, legitimation programmes began to be constructed towards the end of 19th century, based on the history of the peoples of these regions. This led to a search in protohistorical archaeology [Iberians, Celts, Tartessians, etc.) for a possible solution to the political problems caused by a lack of institutional agreement between states and regions.

  引言 本文旨在从考古学的角度分析一个政治问题，正如当前的辩论（包括暴力行为）所表明 的那样，这个问题远远超出了考古学的范畴。在整个 19 世纪，尤其是后半叶，西班牙形成了一种中央集权的政治模式，在这种模式下，国家与伊赫里亚半岛各地区的自治传统之间无法达成政治平衡。由于这一失败，西班牙在 19 世纪末开始根据这些地区人民的历史制定合法化方案。这促使人们在原历史考古学（伊比利亚人、凯尔特人、鞑靼人等）中寻找可能的办法，以解决国家和地区之间缺乏制度性协议所造成的政治问题。
• SELECTIVE PHOSPHORYLATION ON PRIMARY ALCOHOLS OF UNPROTECTED POLYOLS
  作者：Sylvain Ladame、Samantha Claustre、Michèle Willson

  DOI：10.1080/10426500108040232

  日期：2001.8.1

  iododibenzyl phosphate and pyridine, of a very reactive pyridinium salt intermediate. This analysis shows that pyridine behaves as a covalent catalyst like DMAP in acylation reactions from acylchloride. Due to its steric hindrance and high reactivity, this species appears to be the efficient selective phosphorylation reagent but leads to dibenzylphosphoric esters. Under mild conditions, the cleavage of benzyl

  摘要 三联亚磷酸三苄基-碘-吡啶为未保护的α-二醇和多元醇的伯醇的磷酸化反应提供了一种通用的选择性方法。31P NMR 的机理研究证明了由碘二苄基磷酸酯和吡啶形成的非常活泼的吡啶鎓盐中间体。该分析表明，吡啶在酰氯的酰化反应中充当共价催化剂，如 DMAP。由于其空间位阻和高反应性，该物质似乎是有效的选择性磷酸化试剂，但会生成二苄基磷酸酯。在温和条件下，苄基裂解产生磷酸单酯。
• COPOLYMERS OF FORMULA (I) AND USES
  申请人：LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES

  公开号：US20170079928A1

  公开（公告）日：2017-03-23

  Disclosed is a copolymer of following formula (I): in which:—x is an integer between 10 and 250, preferably between 40 and 120, —y is an integer between 4 and 100, preferably between 10 and 100, preferably between 19 and 60, —z is an integer between 0 and (100−y), preferably equal to 0, —R represents an alkyl radical having 1 to 10 carbon atoms, a phospholipid, a glycosaminoglycan or an affinity ligand, and —R′ represents a hydrogen, the —CH 2 —C≡CH group, a —CH 2 -1H-1,2,3-triazole group, a —CH 2 —CH 2 —CH 2 —S—R″ group, in which R″ represents an alkyl radical having 1 to 10 carbon atoms, a phospholipid, a glycosaminoglycan, an affinity ligand or an imaging probe, and the uses of same.

  揭示的是以下公式（I）的共聚物：其中：-x是介于10和250之间的整数，最好介于40和120之间；-y是介于4和100之间的整数，最好介于10和100之间，最好介于19和60之间；-z是介于0和（100-y）之间的整数，最好等于0；-R代表具有1到10个碳原子的烷基基团，磷脂类，糖氨基聚糖或亲和配体；-R'代表氢，-CH2—C≡CH基团，- -1H-1,2,3-三唑基团，- — — —S—R″基团，其中R″代表具有1到10个碳原子的烷基基团，磷脂类，糖氨基聚糖，亲和配体或成像探针，以及其用途。
• CARBODIIMIDES: PART III. (A) A NEW METHOD FOR THE PREPARATION OF MIXED ESTERS OF PHOSPHORIC ACID. (B) SOME OBSERVATIONS ON THE BASE-CATALYZED ADDITION OF ALCOHOLS TO CARBODIIMIDES
  作者：H. G. Khorana

  DOI：10.1139/v54-030

  日期：1954.3.1

  The preparation of a number of N,N′-di-p-tolyl-O-alkyl pseudourea ethers through the alkoxide catalyzed exothermic addition of alcohols to di-p-tolyl carbodiimide is described. Triethyl amine is not effective as a catalyst for such additions. Dicyclohexylcarbodiimide has been found not to undergo such additions at all.The N,N′-diaryl-O-alkyl pseudourea ethers decompose in the presence of mono-and disubstituted

  描述了通过醇盐催化放热加成到二对甲苯基碳二亚胺中，制备许多 N,N'-二对甲苯基-O-烷基假脲醚。三乙胺作为这种加成的催化剂是无效的。已发现二环己基碳二亚胺根本不进行此类加成。N,N'-二芳基-O-烷基假脲醚在单取代和二取代磷酸氢盐存在下分解，以优异的产率形成二芳基脲和中性磷酸叔酯。用这种方法制备了几种混合磷酸酯。