magnesium peroxide

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱土金属有机物
• 英文名称: magnesium peroxide
• 英文别名: magnesium dioxide；manesium peroxide；magnesium;peroxide
• 化学式: MgO₂
• 分子量: 56.3038
• InChiKey: SPAGIJMPHSUYSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.76
• 重原子数：
  3
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.1
• 氢给体数：
  0
• 氢受体数：
  2

ADMET

毒理性

• 解毒与急救

立即急救：确保已经进行了充分去污。如果患者停止呼吸，开始人工呼吸，最好使用需求阀复苏器、气囊面罩装置或口袋面罩，按训练进行操作。根据需要执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果发生呕吐，让患者前倾或置于左侧（如果可能的话，头部向下）以保持呼吸道畅通，防止吸入。保持患者安静，维持正常体温。寻求医疗帮助。/镁及相关化合物/

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Magnesium and Related Compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

基本治疗：建立专利气道（如果需要的话，使用口咽或鼻咽气道）。必要时进行吸痰。观察呼吸不足的迹象，必要时辅助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，并在必要时治疗……。监测休克，并在必要时治疗……。对于眼睛污染，立即用水冲洗眼睛。在转运过程中，用0.9%的生理盐水（NS）连续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的呕吐反射且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……。/镁及其相关化合物/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . /Magnesium and Related Compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于失去意识、严重肺水肿或严重呼吸困难的病人，考虑进行口咽或鼻咽气管插管以控制气道。使用气囊面罩装置的正压通气技术可能有益。考虑使用药物治疗肺水肿……监测心率和必要时治疗心律失常……开始静脉输注D5W/SRP：“保持通路畅通”，最低流速/。如果出现低血容量的迹象，使用0.9%盐水（NS）或乳酸钠林格氏液（LR）。对于伴有低血容量迹象的低血压，谨慎给予液体。如果病人在正常液体容量下出现低血压，考虑使用血管加压药。注意液体过载的迹象……使用丙美卡因盐酸协助眼部冲洗……/镁及其相关化合物/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Magnesium and Related Compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 生态毒性摘录

/其他毒性信息/ 含有MgO2的微孔过滤器在去除和灭活自来水中的细菌和病毒方面显示出有效性。通过这些过滤器收集的铜绿假单胞菌、cepacia假单胞菌和大肠杆菌的数量在24小时内迅速减少到无法检测的水平。相比之下，通过不含MgO2的相同过滤器收集的相同细菌数量要么迅速增加，要么保持不变。脊髓灰质炎病毒1型、埃可病毒1型、呼肠孤病毒3型和轮状病毒SA-11被发现容易吸附到过滤器上。与对照过滤器相比，从含有MgO2的过滤器中可以回收的病毒数量随时间迅速减少。通过过滤器流动的自来水中的细菌或病毒没有显著灭活，强烈表明微生物是在吸附到过滤器上时被灭活的，而不是通过过滤器释放到水中的物质被灭活。即使通过小直径过滤器流动大量自来水，并且在存在被污水污染的自来水的情况下，这些过滤器仍然有效。这种过滤器可能对小社区和个人水系统的水源消毒非常有用。

/OTHER TOXICITY INFORMATION/ Microporous filters containing MgO2 were shown to be effective in the removal and inactivation of bacteria and viruses from tap water. Pseudomonas aeruginosa, P. cepacia and Escherichia coli collected by the filters were found to rapidly decrease in numbers to undetectable levels within 24 hours. In contrast, the same bacteria collected on identical filters not containing MgO2, either rapidly increased in numbers or their numbers remained unchanged. Poliovirus type 1, Echovirus type 1, Reovirus type 3 and Rotavirus SA-11 were found to readily adsorb to the filters. The numbers of viruses which could be recovered from the MgO2 containing filters decreased rapidly with time as compared to control filters. No significant inactivation of bacteria or viruses occurred in tap water passed through the filters, strongly suggesting that the microorganisms were being inactivated while adsorbed to the filters and not by substances released by the filters into the water. The filters remained effective even after the passage of large volumes of tap water through small diameter filters and in the presence of raw sewage contaminated tap water. Such filters could potentially be useful for disinfection of water supplies for small community and individual water systems.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 生态毒性摘录

硫酸盐还原菌（SRB）是无氧条件下引起微生物影响材料腐蚀的主要微生物群体之一，负责产生硫化氢。本研究旨在减少SRB的存在，评估了一种新颖的替代方法，即添加过氧化镁（MgO2）化合物，使用试剂级MgO2和一种商业产品（ORC）作为抑制实验室批处理柱中SRB的手段。当柱中出现黑色硫化物沉淀时，向柱中添加了不同浓度的MgO2。实验结果表明，MgO2能够抑制生物生成的硫化物。SRB的数量、硫化物浓度和硫酸盐还原率（SRR）都有所下降。作为添加剂，ORCtrade mark能够更有效地降低水中的硫化物浓度，并且在使用ORCtrade mark时，SRB的控制效果能够维持更长的时间。氧化还原电位（ORP）的水平与硫化物/硫酸盐比率呈线性关系，是SRB活性的良好指标。通过荧光原位杂交（FISH）确定，添加更多的MgO2可以抑制大部分SRB的生长。硫化物的浓度反映了SRB的丰富程度。有机物的利用率超过了理论上的SRB利用率，表明在添加MgO2之后，兼性异养菌成为了优势菌。本研究的结果为进一步研究评估实际情况下生物腐蚀问题的解决方案提供了有用的信息。

/OTHER TOXICITY INFORMATION/ Sulfate-reducing bacteria (SRB), which cause microbiologically influenced material corrosion under anoxic conditions, form one of the major groups of microorganisms responsible for the generation of hydrogen sulfide. In this study, which is aimed at reducing the presence of SRB, a novel alternative approach involving the addition of magnesium peroxide (MgO2) compounds involving the use of reagent-grade MgO2 and a commercial product (ORC) was evaluated as a means of inhibiting SRB in laboratory batch columns. Different concentrations of MgO2 were added in the columns when black sulfide sediment had appeared in the columns. The experimental results showed that MgO2 is able to inhibit biogenic sulfide. The number of SRB, the sulfide concentration and the sulfate reducing rate (SRR) were decreased. ORC trade mark as an additive was able to decrease more effectively the concentration of sulfide in water and the SRB-control effect was maintained over a longer time period when ORCtrade mark was used. The level of oxidation-reduction potential (ORP), which has a linear relationship to the sulfide/sulfate ratio, is a good indicator of SRB activity. As determined by fluorescence in-situ hybridization (FISH), most SRB growth was inhibited under increasing amounts of added MgO2. The concentration of sulfide reflected the abundance of the SRB. Utilization of organic matter greater than the theoretical SRB utilization rate indicated that facultative heterotrophs became dominant after MgO2 was added. The results of this study could supply the useful information for further study on evaluating the solution to biocorrosion problems in practical situations.

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  magnesium peroxide 在 偏磷酸 作用下， 以 水 为溶剂， 生成 双氧水
  参考文献：
  名称：

  Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: O: MVol.2, 49, page 282 - 283

  摘要：

  DOI：
• 作为产物：
  描述：

  magnesium hydroxide 在 水 、 双氧水 作用下， 以 水 为溶剂， 反应 2.17h， 生成 magnesium peroxide
  参考文献：
  名称：

  US2004/266622

  摘要：

  公开号：
• 作为试剂：
  描述：

  维生素 C 在 magnesium hydroxide 、 magnesium peroxide 作用下， 以 水 为溶剂， 反应 3.5h， 以65%的产率得到magnesium L-threonate
  参考文献：
  名称：

  一种L-苏糖酸镁的制备方法

  摘要：

  本发明提供了一种L‑苏糖酸镁的工业化制备方法。该方法以维生素C为原料，在水溶液中溶解，以过氧化镁为氧化剂，发生反应，之后向反应体系中添加过氧化物酶，除去多余的氧化剂，使用乙醇水溶液结晶常温析晶制得L‑苏糖酸镁。经过工艺优化，筛选出一种可供工业生产的，工艺简单、条件温和、易于操作掌握的，且收率高、环境友好、成本较低的制备方法。

  公开号：

  CN106083567B

文献信息

• A New Model for Magnesium Chemistry in the Upper Atmosphere
  作者：John M. C. Plane、Charlotte L. Whalley

  DOI：10.1021/jp211526h

  日期：2012.6.21

  10–12; and k(MgO + CO → Mg + CO2) = (1.1 ± 0.3) × 10–11 cm3 molecule–1 s–1. Electronic structure calculations of the relevant potential energy surfaces combined with RRKM theory were performed to interpret the experimental results and also to explore the likely reaction pathways that convert MgCO3 and OMgO2 into long-lived reservoir species such as Mg(OH)2. Although no reaction was observed in the laboratory

  本文描述了许多涉及中性含Mg物种的气相反应的动力学研究，这对于上部中层/下部热层区域的流星烧蚀镁的化学起重要作用。这项研究的动机是使用卫星出生的紫外-可见光谱对90公里左右的全球原子镁层进行的最近观测。在实验室中，Mg原子在快流管的上游部分产生热量，然后转化为分子种类MgO，MgO 2，OMgO 2和MgCO 3。通过添加适当的试剂。在更下游添加原子O，并通过激光诱导的荧光在流管的下游端检测到Mg。在300 K下确定以下速率系数：k（MgO + O→Mg + O 2）=（6.2±1.1）×10 –10 ; k（MgO 2 + O→MgO + O 2）=（8.4±2.8）×10 –11 ; k（MgCO 3 + O→MgO 2 + CO 2）≥4.9×10 –12；和k（MgO + CO→Mg + CO 2）=（1.1±0.3）×10 –11 cm 3分子–1 s –1。结合RRKM理论进行
• Substituted cephene-4-carboxylates and their method of preparation
  申请人：Roussel-UCLAF

  公开号：US03962223A1

  公开（公告）日：1976-06-08

  Novel desacetoxycephalosporin derivatives of the formula ##EQU1## in racemic or optically active form or cis and trans forms and mixtures thereof wherein R is selected from the group consisting of aminophenyl and R', R' is selected from the group consisting of phenyl optionally substituted with at least one member of the group consisting of halogen and nitro and a 5 to 6 member heterocyclic group, Y is selected from the group consisting of amino, NHCOOR" where R" is alkyl of 1 to 5 carbon atoms, hydrogen and hydroxy, A is selected from the group consisting of alkyl of 2 to 5 carbon atoms and cycloalkyl of 3 to 7 carbon atoms optionally containing a heteroatom and R.sub.1 is selected from the group consisting of hydrogen, easily acid hydrolyzable group and easily hydrogenolysis removable group, with the proviso that when R is aminophenyl Y is other than amino and NHCOOR" and R.sub.1 is hydrogen and when Y is amino, R.sub.1 is hydrogen and the non-toxic pharmaceutically acceptable addition salts of with organic and inorganic bases and acids where appropriate which have antibacterial activity and a novel process for their preparation and novel intermediates therefor.

  新型去乙酰氧基头孢菌素衍生物，其化学式为##EQU1##，以消旋或光学活性形式或顺反式及其混合物存在，其中R选自氨基苯基和R'，R'选自苯基，该苯基可选择性地被至少一个选自卤素、硝基和5至6元杂环基团的成员取代；Y选自氨基、NHCOOR"（其中R"为1至5个碳原子的烷基、氢和羟基）；A选自2至5个碳原子的烷基和3至7个碳原子的环烷基，该环烷基可选择性地含有一个杂原子；R.sub.1选自氢、易酸解的基团和易氢解移除的基团，但条件是当R为氨基苯基时，Y不是氨基和NHCOOR"，且R.sub.1为氢；当Y为氨基时，R.sub.1为氢；以及与适当的有机和无机碱和酸形成的非毒性药用可接受的加成盐，这些盐具有抗菌活性，并涉及一种制备它们的新方法及其新中间体。
• Benzamide derivatives as vasopressin antagonists
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US06211242B1

  公开（公告）日：2001-04-03

  This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc. and represented by the general formula (I): wherein R1 is aryl optionally substituted with lower alkyl, etc., R2 is lower alkyl, etc., R3 is hydrogen, etc., R4 is aryl, etc., X is CH or N, and Y is CH or N, and pharmaceutically acceptable salts thereof, to processes for the preparation thereof and to a pharmaceutical composition comprising the same.

  该发明涉及具有抗利尿激素拮抗活性的新苯甲酰胺衍生物等，其通式（I）表示如下：其中R1是芳基，可选择地取代为较低烷基等，R2是较低烷基等，R3是氢等，R4是芳基等，X是CH或N，Y是CH或N，以及其药学上可接受的盐，制备方法和含有该物质的药物组合物。
• Electroluminescent efficiency
  申请人：Kwong Raymond

  公开号：US20060008671A1

  公开（公告）日：2006-01-12

  An organic light emitting device is provided. The device has an anode, a cathode, and an emissive layer disposed between the anode and the cathode. The emissive layer further includes a molecule of Formula I wherein an alkyl substituent at position R′ 5 results in high efficiency and operational stability in the organic light emitting device.

  提供一种有机发光器件。该器件具有阳极、阴极和位于阳极和阴极之间的发射层。发射层进一步包括式I的分子，其中在位置R'5处的烷基取代基导致有机发光器件具有高效率和操作稳定性。
• Pharmaceutical compositions and methods of inhibiting phenylethanolamine
  申请人：SmithKline Corporation

  公开号：US03988339A1

  公开（公告）日：1976-10-26

  Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using 7 and/or 8 substituted 1,2,3,4-tetrahydroisoquinoline compounds.

  药物组合物和使用7和/或8取代的1,2,3,4-四氢异喹啉化合物抑制苯乙醇胺N-甲基转移酶的方法。