多硫化钡硫钡粉

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱土金属有机物
• 中文名称: 多硫化钡硫钡粉
• 中文别名: 硫钡合剂
• 英文名称: barium(2+);sulfide
• 化学式: BaS
• 分子量: 169.39
• InChiKey: CJDPJFRMHVXWPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.38
• 重原子数：
  2
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  1
• 氢给体数：
  0
• 氢受体数：
  1

ADMET

代谢

硫酸钡是一种不溶于水和酸的白色粉末，常用于医疗成像（如X射线）和工业应用。在医疗成像中，硫酸钡被用作对比剂，因为它在X射线下不透明，可以帮助医生更清楚地看到内部器官的结构。硫酸钡也被用于石油工业中的钻井泥浆，以及作为某些陶瓷和油漆的成分。由于硫酸钡的化学性质相对稳定，它通常被认为对人体和环境相对安全，但在高浓度下或长期接触下仍可能对健康造成影响。

Barium compounds are absorbed via ingestion and inhalation, the extent of which depends on the individual compound. In the body, the majority of the barium is found in the bone, while small amounts exists in the muscle, adipose, skin, and connective tissue. Barium is not metabolized in the body, but it may be transported or incorporated into complexes or tissues. Barium is excreted in the urine and faeces. (L214)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

钡是一种竞争性的钾通道拮抗剂，它阻断了细胞内钾的被动外流，导致钾从细胞外向细胞内间隔转移。细胞内钾的转移导致静息膜电位降低，使肌肉纤维失去电兴奋性，从而引起瘫痪。钡的这些效应中，有些可能也是由于钡诱导的神经肌肉阻滞和膜去极化所引起的。(L214)

Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis. Some of these barium's effects may also be due to barium induced neuromuscular blockade and membrane depolarization. (L214)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

对人类无致癌性（未列入国际癌症研究机构IARC清单）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

不同钡化合物的健康影响取决于化合物在水中或胃内容物中的溶解程度。在低剂量时，钡作为一种肌肉刺激剂，而较高剂量则影响神经系统，导致心脏不规律、震颤、虚弱、焦虑、呼吸困难、瘫痪甚至可能死亡。钡还可能引起胃肠不适，损害肾脏并导致体重下降。

The health effects of the different barium compounds depend on how well the compound dissolves in water or the stomach contents. At low doses, barium acts as a muscle stimulant, while higher doses affect the nervous system, causing cardiac irregularities, tremors, weakness, anxiety, dyspnea, paralysisand possibly death. Barium may also cause gastrointestinal disturbances, damage the kidneys and cause decreases in body weight. (L214)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

口服（L214）；吸入（L214）

Oral (L214) ; inhalation (L214)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

摄入过量的钡可能引起呕吐、腹部绞痛、腹泻、呼吸困难、血压升高或降低、面部周围麻木和肌肉无力。高剂量可能导致心律变化或麻痹，甚至可能死亡。

Ingesting excess barium may cause vomiting, abdominal cramps, diarrhea, difficulties in breathing, increased or decreased blood pressure, numbness around the face, and muscle weakness. High levels may result in changes in heart rhythm or paralysis and possibly death. (L214)

来源:Toxin and Toxin Target Database (T3DB)

反应信息

• 作为反应物：
  描述：

  多硫化钡硫钡粉 、 (alphaS,betaR)-alpha-(2,4-Difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol; [S-(R*,S*)]-alpha-(2,4-Difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol 、 硫酸 生成 barium sulfate 、 strontium sulfate 、 硫化氢
  参考文献：
  名称：

  Titania composite and preparing method thereof

  摘要：

  本发明提供了一种钛酸钡复合材料及其制备方法。所述钛酸钡复合材料包括内核和涂层膜层，其中内核为具有亚球形形状的硫酸钡晶体和/或硫酸锶晶体，粒径小于1μm，白度大于98%，涂层膜层为纳米金红石型钛酸钛。其制备方法包括以下步骤：(a)制备硫酸钡或硫酸锶；(b)涂层处理；(c)将钛酸钡复合材料进行高温热处理；(d)进行后处理。通过化学合成亚球形亚微米硫酸钡或硫酸锶，然后水解并涂覆钛酸钛形成涂层膜层，使钛酸钛均匀生长，从而获得亚球形钛酸钡复合材料。该复合材料的粒径小，粒径分布范围可控。

  公开号：

  US08221834B2

文献信息

• TITANIA COMPOSITE AND PREPARING METHOD THEREOF
  申请人：Hua Dong

  公开号：US20110253012A1

  公开（公告）日：2011-10-20

  A titania composite and a preparing method thereof are provided. The titania composite comprises an inner core and a coating film layer, wherein the inner core is a barium sulfate crystal and/or a strontitum sulfate crystal with subsphaeroidal shape, having a particle size of less than 1 μm and whiteness of more than 98%, and the coating film layer is nano rutile titania. The preparing method thereof comprises the following steps: (a) preparing barium sulfate or strontium sulfate; (b) coating treatment; (c) subjecting the titania composite to a high-temperature heat treatment; and (d) subjecting the titania composite to a post treatment. The subsphaeroidal titania composite is obtained by chemically synthesizing a subsphaeroidal submicron barium sulfide or strontium sulfide, and then hydrolyzing and coating thereon to form a coating film layer of titania to make titania grow evenly. The particle size of the titania composite is small, and the particle size distribution range of the titania composite is controllable.

  本发明提供了一种钛酸钡复合材料及其制备方法。该钛酸钡复合材料包括内核和涂层膜层，其中内核是具有亚球形形状的硫酸钡晶体和/或硫酸锶晶体，粒径小于1μm，白度大于98％，涂层膜层是纳米金红石型钛酸钛。其制备方法包括以下步骤：(a)制备硫酸钡或硫酸锶；(b)涂层处理；(c)将钛酸钡复合材料进行高温热处理；(d)将钛酸钡复合材料进行后处理。通过化学合成亚球形亚微米硫酸钡或硫酸锶，然后水解和涂层形成钛酸钛的涂层膜层，使钛酸钛均匀生长，获得亚球形钛酸钡复合材料。该钛酸钡复合材料的粒径小，粒径分布范围可控。