N-(p-anisyldiphenylmethyl) β-alanine | 135672-63-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: N-(p-anisyldiphenylmethyl) β-alanine
• 英文别名: 3-(N-monomethoxytritylamino)propionic acid；N-(4-monomethoxytrityl)-β-alanine；N-(4-methoxytrityl)-β-alanine；N-monomethoxytrityl-β-alanine；3-[[(4-Methoxyphenyl)-diphenylmethyl]amino]propanoic acid
• CAS: 135672-63-8
• 化学式: C₂₃H₂₃NO₃
• 分子量: 361.441
• InChiKey: WHONSVXAUKZMFC-UHFFFAOYSA-N

物化性质

• 沸点：
  533.1±50.0 °C(Predicted)
• 密度：
  1.166±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  紫杉醇 、 N-(p-anisyldiphenylmethyl) β-alanine 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以95%的产率得到[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-[3-[[(4-methoxyphenyl)-diphenylmethyl]amino]propanoyloxy]-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
  参考文献：
  名称：

  Hwu, Jih Ru; Tsay, Shwu-Chen; Sambaiah, Thota, Mendeleev Communications, 2001, # 6, p. 216 - 217

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲氧基三苯基氯甲烷 、 β-丙氨酸 在 二乙胺 作用下， 以 水 、 异丙醇 为溶剂， 反应 15.0h， 以55%的产率得到N-(p-anisyldiphenylmethyl) β-alanine
  参考文献：
  名称：

  Synthesis of New N-(Trifluoroacetyl) Doxorubicin Analogues

  摘要：

  Four new 14-O-acyl derivatives of N-(trifluoroacetyl) doxorubicin possessing a terminal primary amino group have been synthesized in a two steps process under mild reaction conditions.

  DOI：

  10.1080/00397919108019778

文献信息

• Two Successive Reactions on a DNA Template: A Strategy for Improving Background Fluorescence and Specificity in Nucleic Acid Detection
  作者：Raphael M. Franzini、Eric T. Kool

  DOI：10.1002/chem.201002426

  日期：2011.2.11

  cleavable linkers. When a 2‐STAR quenched probe successively binds adjacent to two mono‐triphenylphosphine‐(TPP)‐DNAs or one dual‐TPP‐DNA, the two quenchers are released, resulting in a fluorescence signal. Because of the requirement for two consecutive reactions, 2‐STAR probes display an unprecedented level of sequence specificity for template‐mediated probe designs. At the same time, background emission

  我们报告了一种模板介导的荧光化学的新策略，可提高核酸荧光检测的性能。在这种方法中，需要两个连续的模板化反应来诱导荧光信号，而不仅仅是一个。这些新的荧光素标记的寡核苷酸探针，称为 2-STAR（STAR=Staudinger 触发的 α-叠氮醚释放）探针，包含两个猝灭基团，由单独的可还原裂解接头连接。当 2-STAR 淬灭探针连续与相邻的两个单三苯基膦-(TPP)-DNA 或一个双 TPP-DNA 结合时，两个淬灭剂被释放，产生荧光信号。由于需要两个连续反应，2-STAR 探针显示出模板介导的探针设计前所未有的序列特异性水平。同时，
• [EN] REDUCTIVE RELEASE PROBES CONTAINING A CHEMOSELECTIVELY CLEAVABLE ALPHA-AZIDOETHER LINKER AND METHODS OF USE THEREOF<br/>[FR] SONDES À LIBÉRATION RÉDUCTRICE CONTENANT UN LIANT ALPHA-AZIDOÉTHER CLIVABLE DE FAÇON CHÉMIOSÉLECTIVE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2011005821A1

  公开（公告）日：2011-01-13

  Probes comprising one or more selectively cleavable α-azidoether moieties are provided; and linkers comprising the one or more selectively cleavable α-azidoether moieties. The α-azidoether moiety will undergo a Staudinger reaction with a suitable reducing agent, resulting in cleavage. The probes find use in a variety of detection assays, e.g. specific polynucleotide binding assays, polypeptide binding assays, etc. The cleavable linkers are suitable for synthetic reactions, e.g. to prepare probes of the invention; in the synthesis of cleavable peptide conjugates; and the like.

  提供了包含一个或多个可选择裂解的α-叠氮醚基团的探针；以及包含一个或多个可选择裂解的α-叠氮醚基团的连接剂。α-叠氮醚基团将与适当的还原剂发生斯陶丁格反应，导致裂解。这些探针可用于各种检测分析中，例如特定多核苷酸结合分析、多肽结合分析等。可裂解的连接剂适用于合成反应，例如用于制备本发明的探针；用于合成可裂解的肽共轭物等。
• Interstrand cross-link of DNA by covalently linking a pair of abasic sites
  作者：Kohei Ichikawa、Naoshi Kojima、Yu Hirano、Toshie Takebayashi、Keiko Kowata、Yasuo Komatsu

  DOI：10.1039/c2cc16785a

  日期：——

  A pair of apurinic/apyrimidinic sites formed in DNA has been covalently connected with bis(aminooxy) derivatives. The efficacy of the interstrand cross-link is associated with the structural tethering of two aminooxy groups. The interstrand cross-link constructed stable DNA scaffolds for enzyme alignment.

  DNA 中形成的一对嘌呤/近嘧啶位点与双（氨基氧基）衍生物进行了共价连接。链间交联的功效与两个氨基氧基的结构系链有关。链间交联为酶配位构建了稳定的 DNA 支架。
• REDUCTIVE RELEASE PROBES CONTAINING A CHEMOSELECTIVELY CLEAVABLE ALPHA-AZIDOETHER LINKER AND METHODS OF USE THEREOF
  申请人：Franzini Raphael M.

  公开号：US20120178086A1

  公开（公告）日：2012-07-12

  Probes comprising one or more selectively cleavable α-azidoether moieties are provided; and linkers comprising the one or more selectively cleavable α-azidoether moieties. The α-azidoether moiety will undergo a Staudinger reaction with a suitable reducing agent, resulting in cleavage. The probes find use in a variety of detection assays, e.g. specific polynucleotide binding assays, polypeptide binding assays, etc. The cleavable linkers are suitable for synthetic reactions, e.g. to prepare probes of the invention; in the synthesis of cleavable peptide conjugates; and the like.

  提供了包含一个或多个可选择性裂解的α-叠氮醚基团的探针；以及包含一个或多个可选择性裂解的α-叠氮醚基团的连接体。α-叠氮醚基团将与合适的还原剂发生斯陶丁格反应，导致裂解。这些探针适用于各种检测分析中，例如特定的多核苷酸结合分析、多肽结合分析等。可裂解的连接体适用于合成反应，例如制备本发明的探针；在裂解肽共轭物的合成中使用等。
• Synthesis and immunofluorescence assay of a new biotinylated paclitaxel
  作者：Thota Sambaiah、Ke-Yung King、Shwu-Chen Tsay、Nai-Wen Mei、Sharcon Hakimclahi、Yiu-Kay Lai、Chien-Hui Lieu、Jih Ru Hwu

  DOI：10.1016/s0223-5234(02)01337-5

  日期：2002.4

  7-(5'-Biotinylamidopropanoyl)paclitaxel was synthesised by chemical methods. its immunofluorescence assay and the cell uptake experiments were performed by use of human leukemia U937 cells. The results indicate that paclitaxel is arresting cell cycle at the G(2)M phase only. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.