2',4',5'-tribromofluorescein | 25709-83-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2',4',5'-tribromofluorescein
• 英文别名: 2’,4’,5’-tribromofluorescein；2,4,5-Tribromfluorescein；2',4',5'-tribromo-3',6'-dihydroxy-spiro[phthalan-1,9'-xanthen]-3-one；2',4',5'-Tribrom-3',6'-dihydroxy-spiro[phthalan-1,9'-xanthen]-3-on；2',4',5'-tribromo-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
• CAS: 25709-83-5
• 化学式: C₂₀H₉Br₃O₅
• 分子量: 569.0
• InChiKey: YKZJCSJCUCCADE-UHFFFAOYSA-N

物化性质

• 沸点：
  636.3±55.0 °C(Predicted)
• 密度：
  2.31±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  28
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2932999099

反应信息

• 作为产物：
  描述：

  荧光素 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以31%的产率得到2',4',5'-tribromofluorescein
  参考文献：
  名称：

  通过重金属曙红盐造影剂进行3D无损成像

  摘要：

  常规组织学是基于3D活检的2D切片评估的破坏性技术。通过使用3D X射线组织学，可以克服这些障碍，但由于软组织固有的低衰减特性，其应用仍然受到限制。为了解决此问题，可以在X射线计算机断层扫描成像（CT）之前对组织进行染色，以增强软组织的X射线对比度。溴化荧光素盐的评估显示，溴原子数和所施加阳离子对获得的对比度增强具有相互影响。事实证明，二溴荧光素钡盐是理想的X射线造影剂，可进行3D成像并随后应用标准组织学技术补充反染。

  DOI：

  10.1002/chem.202005203

文献信息

• [EN] NOVEL HEAVY METAL ION-HEMATEIN-COMPLEXES USEFUL AS EX VIVO CONTRAST AGENT FOR A COMPUTED TOMOGRAPHY SCANNING OF A BIOLOGICAL SAMPLE, EX VIVO METHOD FOR INVESTIGATING A BIOLOGICAL SAMPLE, AND USE OF THE COMPLEXES<br/>[FR] NOUVEAUX COMPLEXES ION DE MÉTAL LOURD-HÉMATÉINE UTILES EN TANT QU'AGENT DE CONTRASTE EX VIVO POUR UN BALAYAGE DE TOMOGRAPHIE ASSISTÉE PAR ORDINATEUR D'UN ÉCHANTILLON BIOLOGIQUE, PROCÉDÉ EX VIVO POUR EXAMINER UN ÉCHANTILLON BIOLOGIQUE, ET UTILISATION DES COMPLEXES
  申请人：UNIV MUENCHEN TECH

  公开号：WO2019073064A1

  公开（公告）日：2019-04-18

  The present invention relates to specific complexes comprising heavy metal ions having an atomic number of 23 or higher and 83 or lower (in particular Ag1+, Ba2+,Pb2 +, Gd3+ and Bi3+) and one or more hematein ligand(s). In particular, the invention relates to the use of the complexes as ex vivo contrast agents for a computed tomography scanning of a biological sample. Moreover, the invention relates to specific ex vivo methods for investigating a biological sample by means of computed tomography scanning methods, wherein the method comprises staining the biological sample with a solution comprising one or more of the complex(es); or wherein the method comprises staining the biological sample with a staining solution comprising hematein, and separately contacting the biological sample with one or more staining solution(s) comprising one or more heavy metal ions having an atomic number of 23 or higher and 83 or lower (in particular Ag1+, Ba2+,Pb2 +, Gd3+ and Bi3+).

  本发明涉及包含具有原子序数为23或更高和83或更低的重金属离子（特别是Ag1+、Ba2+、Pb2+、Gd3+和Bi3+）和一个或多个赫马丁配体的特定络合物。具体而言，本发明涉及将这些络合物用作生物样本的体外造影剂，用于计算机断层扫描。此外，本发明涉及通过计算机断层扫描方法研究生物样本的特定体外方法，其中该方法包括用含有一个或多个该络合物的溶液对生物样本进行染色；或者该方法包括用含有赫马丁的染色溶液对生物样本进行染色，并分别将生物样本与含有原子序数为23或更高和83或更低的重金属离子（特别是Ag1+、Ba2+、Pb2+、Gd3+和Bi3+）的一个或多个染色溶液接触。
• Leave-in color conditioner
  申请人：Pollack George

  公开号：US20050198746A1

  公开（公告）日：2005-09-15

  The invention is directed to novel hair dye compositions, novel leave-in conditioners, and novel leave-in conditioners with a hair coloring effect. Hair dye compositions, leave-in conditioners, and leave-in conditioners with hair coloring effect may include a styrene/vinylpyrrolidone copolymer emulsion.

  本发明涉及新型染发剂组合物、新型留香护发素以及具有染发效果的新型留香护发素。染发剂组合物、留香护发素和具有染发效果的留香护发素可能包括苯乙烯/吡咯烷酮共聚物乳液。
• Graichen; Molitor, Journal of the Association of Official Agricultural Chemists, 1959, vol. 42, p. 149,159
  作者：Graichen、Molitor

  DOI：——

  日期：——
• NOVEL HEAVY METAL ION-LIGAND-COMPLEXES USEFUL AS EX VIVO CONTRAST AGENT FOR A COMPUTED TOMOGRAPHY SCANNING OF A BIOLOGICAL SAMPLE, EX VIVO METHOD FOR INVESTIGATING A BIOLOGICAL SAMPLE, AND USE OF THE COMPLEXES
  申请人：TECHNISCHE UNIVERSITÄT MÜNCHEN

  公开号：US20210371436A1

  公开（公告）日：2021-12-02

  The present invention relates to specific complexes comprising heavy metal ions having an atomic number of 29 or higher and 83 or lower (preferably 29 or higher and 81 or lower) and one or more ligand(s) selected from the group consisting of specific xanthene derivatives, preferably eosin Y and/or erythrosin B ligand(s). In particular, the invention relates to the use of the complexes as ex vivo contrast agents for a computed tomography scanning of a biological sample. Moreover, the invention relates to specific ex vivo methods for investigating a biological sample by means of computed tomography scanning methods, wherein the method comprises staining the biological sample with a solution comprising one or more of the complex(es); or wherein the method comprises staining the biological sample with a staining solution comprising one or more specific xanthenes derivatives (e.g. eosin Y and/or erythrosin B), and separately contacting the biological sample with one or more staining solution(s) comprising one or more heavy metal ions having an atomic number of 29 or higher and 83 or lower (preferably 29 or higher and 81 or lower).
• US5332504A
  申请人：——

  公开号：US5332504A

  公开（公告）日：1994-07-26