Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary... . Monitor for shock and treat if necessary... . Anticipate seizures and treat if necessary... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool... . Cover skin burns with dry sterile dressings after decontamination... . /Poison A and B/
In a metabolism study, mepiquat chloride, labeled with 14C in the 2,6-carbon atoms of the ring structure (radiochemical purity: 98%), was administered to young adult Sprague-Dawley rats (5/sex/group) either iv or orally. During the study, the rats received a standard diet (pellets) as follows: for body weight 150 g: 10% of body weight + 3 g; for body weight 150 g, 10% of body weight + 2 g. Water was provided ad libitum. Mepiquat chloride was absorbed rapidly from the stomach, distributed evenly in the intra and extracellular compartments of the blood, demonstrated high bioavailability via the oral route, was excreted mostly in urine, and did not accumulate in tissues. Other excretions of the administered radioactivity were as follows: feces, 2-15%; exhaled air, (14CO2 ), 0.20%; and bile, 0.23-0.31%. The bioavailability of mepiquat chloride appears to depend on the presence of food in the GI tract. In the two male rats used in the study of pulmonary elimination of mepiquat chloride as C-volatiles, which had access to food immediately after dosing, the bioavailability was much lower (58%) than that of a similar treatment group in which food was withheld until 4 hours after dosing (79%). Mepiquat chloride did not accumulate in tissues.
In a metabolism study, mepiquat chloride, labeled with 14C in the 2,6-carbon atoms of the ring structure (radiochemical purity: 98%), was administered to young adult Sprague-Dawley rats (5/sex/group) either iv or orally. ... Urine, feces and bile samples from various treatments were used for studies of the metabolic fate of mepiquat chloride. In all cases, only the unchanged compound could be detected. Therefore, there was no biotransformation of mepiquat chloride in vivo. The potential metabolites, such as 1-methylpiperidine or piperidine, were not detected.
The plant growth regulators chlormequat and/or mepiquat were investigated in cereals from the Danish harvest of 1999 where 83% of the samples contained chlormequat (n = 46) compared with 87% of the samples from the 1997 harvest (n = 52). The average concentration of chlormequat in 1999 was 0.32 mg/kg compared with 0.23 mg/kg in 1997. At 2.9 mg/kg, one sample of wheat bran was exceeding the MRL of 2 mg/kg for wheat. The intakes of the pesticides through the diet of cereals were estimated to comprise 1% of the ADI for chlormequat for an adult Dane.
Kinetics of reactions of cyclic secondary amines with 2,4-dinitro-1-naphthyl ethyl ether in dimethyl sulfoxide solution. Spectacular difference between the behavior of pyrrolidine and piperidine
[EN] ACC INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE L'ACC ET UTILISATIONS ASSOCIÉES
申请人：GILEAD APOLLO LLC
公开号：WO2017075056A1
公开（公告）日：2017-05-04
The present invention provides compounds I and II useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
[EN] BICYCLYL-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS<br/>[FR] COMPOSÉS ISOTHIAZOLINE SUBSTITUÉS PAR UN BICYCLYLE
申请人：BASF SE
公开号：WO2014206910A1
公开（公告）日：2014-12-31
The present invention relates to bicyclyl-substituted isothiazoline compounds of formula (I) wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.
The present invention provides triazole compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
本发明提供了三唑化合物，可用作乙酰辅酶A羧化酶（ACC）的抑制剂，以及其组合物和使用方法。
3-AMINOXALYL-AMINOBENZAMIDE DERIVATIVES AND INSECTICIDAL AND MITICIDAL AGENTS CONTAINING SAME AS ACTIVE INGREDIENT
申请人：Usui Shuichi
公开号：US20120022263A1
公开（公告）日：2012-01-26
The present invention herein provides a 3-aminooxalylaminobenzamide derivative which is used as an insecticide or miticide.
The 3-aminooxalylaminobenzamide derivative is one represented by the following general formula [1]:
(R
1
and R
2
each represent, for instance, a C
1
to C
3
alkoxy group or a C
1
to C
3
haloalkoxy group; R
3
and R
4
each represent, for instance, a C
1
to C
8
alkyl group or a C
1
to C
8
haloalkyl group; R
5
represents, for instance, a C
1
to C
5
haloalkyl group; R
6
and R
7
each represent, for instance, a hydrogen atom or a C
1
to C
5
alkyl group; Y represents, for instance, a hydrogen atom or a halogen atom; Z represents, for instance, a hydrogen atom; n is an integer ranging from 0 to 4 and m is an integer ranging from 0 to 2).
AZOLE DERIVATIVE, INTERMEDIATE COMPOUND, METHOD FOR PRODUCING AZOLE DERIVATIVE, AGRICULTURAL OR HORTICULTURAL CHEMICAL AGENT, AND PROTECTIVE AGENT FOR INDUSTRIAL MATERIAL
申请人：Kureha Corporation
公开号：US20200288714A1
公开（公告）日：2020-09-17
It is provided a plant disease controlling agent having low toxicity to human and animals and excellent handling safety, and showing excellent controlling effects on various plant diseases and high antibiotic action to plant disease germs.
A compound represented by the following the general formula (I), or an N-oxide or agrochemically acceptable salt thereof.
