7-O-[6-O-(1-O-vanillic acid 4-O-β-D-glucopyranosyl)-β-D-glucopyranosyl]-6-methoxycoumarin

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 单宁
• 英文名称: 7-O-[6-O-(1-O-vanillic acid 4-O-β-D-glucopyranosyl)-β-D-glucopyranosyl]-6-methoxycoumarin
• 化学式: C₃₀H₃₄O₁₇
• 分子量: 666.59
• InChiKey: KWAWFCLVDHLAMW-QXSDQSKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  47.0
• 可旋转键数：
  11.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  253.5
• 氢给体数：
  7.0
• 氢受体数：
  16.0

反应信息

• 作为反应物：
  描述：

  7-O-[6-O-(1-O-vanillic acid 4-O-β-D-glucopyranosyl)-β-D-glucopyranosyl]-6-methoxycoumarin 在 盐酸 作用下， 以 水 为溶剂， 反应 2.0h， 生成 葡萄糖
  参考文献：
  名称：

  Quinic acid derivatives and coumarin glycoside from the roots and stems of Erycibe obtusifolia

  摘要：

  A new quinic acid derivative (1) and a new coumarin glycoside (8), together with six known compounds (2-7) were isolated from the roots and stems of Erycibe obtusifolia. The structures of the new compounds were elucidated by spectroscopic and chemical analyses. The in vitro antiviral activity against the respiratory syncytial virus (RSV) of seven quinic acid derivatives was evaluated by cytopathic effect (CPE) reduction assay. Among them, the dicaffeoylquinic acids (6 and 7) displayed potent in vitro anti-RSV activity. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.phytol.2015.10.002

文献信息

• Quinic acid derivatives and coumarin glycoside from the roots and stems of Erycibe obtusifolia
  作者：Long Fan、Ying Wang、Ning Liang、Xiao-Jun Huang、Chun-Lin Fan、Zhen-Long Wu、Zhen-Dan He、Yao-Lan Li、Wen-Cai Ye

  DOI：10.1016/j.phytol.2015.10.002

  日期：2015.12

  A new quinic acid derivative (1) and a new coumarin glycoside (8), together with six known compounds (2-7) were isolated from the roots and stems of Erycibe obtusifolia. The structures of the new compounds were elucidated by spectroscopic and chemical analyses. The in vitro antiviral activity against the respiratory syncytial virus (RSV) of seven quinic acid derivatives was evaluated by cytopathic effect (CPE) reduction assay. Among them, the dicaffeoylquinic acids (6 and 7) displayed potent in vitro anti-RSV activity. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.