四溴金(III)酸钾二水合物 | 14323-32-1

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属盐
• 中文名称: 四溴金(III)酸钾二水合物
• 中文别名: 四溴合金酸钾n水合物；溴金酸钾；四溴金(III)酸钾二水；溴化金钾(二水)
• 英文名称: potassium tetrabromoaurate(III)
• 英文别名: potassium tetrabromoaurate；K[Au(bromide)4]；potassium;tetrabromogold(1-)
• CAS: 14323-32-1
• 化学式: AuBr₄*K
• 分子量: 555.681
• InChiKey: GVZKACIZKAONNB-UHFFFAOYSA-J

物化性质

• 熔点：
  decomposes at 120℃ [CRC10]
• 稳定性/保质期：
  在常温常压下稳定，需避免接触氨和光。

计算性质

• 辛醇/水分配系数(LogP)：
  -14.98
• 重原子数：
  6
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• TSCA：
  Yes
• WGK Germany：
  3
• 安全说明：
  S36/37
• 危险类别码：
  R34
• 储存条件：
  常温下应密闭避光，存放在通风干燥处。

SDS

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Section 1: Product Identification
Chemical Name: Potassium tetrabromoaurate (III) dihydrate, 99%
CAS Registry Number: 14323-32-1
Formula: KAuBr4.2H2O
EINECS Number: 238-268-8
Chemical Family: halometallate salt
Synonym: Potassium gold tetrabromide hydrate

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Section 2: Composition and Information on Ingredients
Ingredient CAS Number Percent ACGIH (TWA) OSHA (PEL)
Title Compound 14323-32-1 100% no data no data

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Section 3: Hazards Identification
Emergency Overview: Irritating to skin, eyes and respiratory tract.
Primary Routes of Exposure: Contact with skin and eyes. Inhalation of dust.
Eye Contact: Causes slight to mild irritation of the eyes.
Skin Contact: Causes slight to mild irritation of the skin.
Inhalation: Irritating to the nose, mucous membranes and respiratory tract.
Ingestion may lead to dermatitis, dizziness, metallic taste, abdominal cramps, vomiting, bloody diarrhea,
Ingestion:
weakness, and convulsions.
Irritating to skin, eyes and respiratory tract. Gold compounds may cause impairment of kidney and bone
Acute Health Affects:
marrow function, abdominal cramps, vomiting, bloody diarrhea, weakness, and convulsions.
Prolonged exposure to gold compounds may lead to reduced red and white blood cell generation. Prolonged
Chronic Health Affects:
exposure to bromides may cause skin rashes, memory loss, irritability, and headache.
NTP: No
IARC: No
OSHA: No

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SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.

---

SECTION 5: Fire Fighting Measures
Flash Point: not applicable
Autoignition Temperature: none
Explosion Limits: none
Extinguishing Medium: None. Material is non-flammable.
Special Fire Fighting Procedures: No special fire fighting procedures required.
Hazardous Combustion and none
Decomposion Products:
Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards.

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SECTION 6: Accidental Release Measures
To avoid raising dust, small spills may be mixed with diatomaceous earth, sand, vermiculite or other suitable
Spill and Leak Procedures:
inert material and swept up.

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SECTION 7: Handling and Storage
Handling and Storage: Store solid in a tightly sealed container.

---

SECTION 8: Exposure Controls and Personal Protection
Eye Protection: Always wear approved safety glasses when handling a chemical substance in the laboratory.
Skin Protection: Wear protective clothing and gloves. Consult with glove manufacturer to determine the proper type of glove.
Ventilation: Material may form a fine dust. If possible, handle the material in an efficient fume hood.
If in form of fine dust and ventilation is not available a respirator should be worn. The use of respirators
Respirator:
requires a Respirator Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation: Material may form a fine dust. If possible, handle the material in an efficient fume hood.
Additional Protection: No additional protection required.

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SECTION 9: Physical and Chemical Properties
Color and Form: reddish-brown xtl.
Molecular Weight: 555.71 (591.74)
Melting Point: no data
Boiling Point: no data
Vapor Pressure: not applicable
Specific Gravity: no data
Odor: none
Solubility in Water: very soluble

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SECTION 10: Stability and Reactivity
Stability: air and moisture stable
Hazardous Polymerization: no hazardous polymerization
Conditions to Avoid: none
Incompatibility: Active metals
Decomposition Products: potassium bromide, gold, bromine, hydrobromic acid and water.

---

SECTION 11: Toxicological Information
RTECS Data: No information available in the RTECS files.
Carcinogenic Effects: no data
Mutagenic Effects: no data
Tetratogenic Effects: no data

---

SECTION 12: Ecological Information
Ecological Information: No information available

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SECTION 13: Disposal Considerations
Disposal: Dispose of according to local, state and federal regulations.

---

SECTION 14: Transportation
Shipping Name (CFR): Non-hazardous
Hazard Class (CFR): NA
Additional Hazard Class (CFR): NA
Packaging Group (CFR): NA
UN ID Number (CFR): NA
Shipping Name (IATA): Non-hazardous
Hazard Class (IATA): NA
Additional Hazard Class (IATA): NA
Packaging Group (IATA): NA
UN ID Number (IATA): NA

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SECTION 15: Regulatory Information
TSCA: Listed in the TSCA inventory.
SARA (Title 313): Title compound not listed.
Second Ingredient: none

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  四溴金(III)酸钾二水合物 以 硫酸 为溶剂， 生成 金
  参考文献：
  名称：

  Honeycomb nanogold networks with highly active sites

  摘要：

  描述了使用电化学产生的氢气泡模板形成大孔蜂窝金。合成过程诱导形成具有增强的电催化和表面增强拉曼散射特性的高活性表面。

  DOI：

  10.1039/c0cc03696j
• 作为产物：
  描述：

  金 在 KBr 、 Br₂ 作用下， 以 水 为溶剂， 生成 四溴金(III)酸钾二水合物
  参考文献：
  名称：

  Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Au: MVol.3, 6.3, page 618 - 621

  摘要：

  DOI：
• 作为试剂：
  描述：

  5-溴-2-硝基苯甲醛 在 tin(II) chloride dihdyrate 、 四溴金(III)酸钾二水合物 作用下， 以 甲醇 、 乙酸乙酯 、 1,2-二氯乙烷 为溶剂， 反应 24.0h， 生成 10-bromo-6-tosyl-5,6-dihydrodibenzo[b,f][1,8]naphthyridine
  参考文献：
  名称：

  金（III）催化的2-氨基吡咯和喹啉基聚氮杂杂环的位点选择和发散合成

  摘要：

  描述了一种在温和的反应条件下，通过简单的金（III）催化剂从乙酰胺和邻氨基苯甲酸酯中构建2-氨基吡咯和喹啉稠合的聚氮杂环杂环化合物的简便，定点和分散的方法。这种单罐策略使用容易获得的起始原料，以高度一步步和原子经济的方式进行，具有广阔的底物范围和扩大规模的潜力。在该串联反应中成功的关键要素是通过催化剂引导的，优选的通过在酰胺上的亲核苄基-2-呋喃甲基甲基部分猝灭原位生成的金卡宾中间体，以替代已知的CHH环化生成吲哚的方法。

  DOI：

  10.1002/anie.201810369

文献信息

• Gold Dithiocarbamate Derivatives as Potential Antineoplastic Agents:  Design, Spectroscopic Properties, and in Vitro Antitumor Activity
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  DOI：10.1021/ic048260v

  日期：2005.3.21

  Moreover, the electrochemical properties of the designed compounds have been studied through cyclic voltammetry. All the synthesized gold complexes have been tested for their in vitro cytotoxic activity. Remarkably, most of them, in particular gold(III) derivatives of N,N-dimethyldithiocarbamate and ethylsarcosinedithiocarbamate, have been proved to be much more cytotoxic in vitro than cisplatin,

  目前，顺铂（cis-diamminodichloroplatinum（II））是使用最多的抗癌药物之一，因为它可有效治疗70-90％的睾丸以及与其他药物联合治疗的卵巢小细胞肺癌，膀胱，脑和乳腺肿瘤。无论如何，尽管它具有很高的功效，但仍表现出一些与它在根治性治疗中的使用有关的临床问题，例如严重的正常组织毒性（特别是肾毒性）以及对治疗的初始和获得性耐药性的频繁发生。为了获得具有比顺铂更高的生物利用度，更高的细胞毒性和更低的副作用的化学治疗指数的化合物，我们在此报告了一些具有二硫代氨基甲酸酯配体的金（I）和金（III）配合物（DMDT = N，N-二甲基二硫代氨基甲酸酯； DMDTM = S-甲基-N，N-二甲基二硫代氨基甲酸酯；ESDT =乙基肌氨酸二硫代氨基甲酸酯），已通过元素分析，电导率测量，一维和二维NMR，FT-IR和UV-vis光谱以及热分析的方法进行了合成，纯化和表征。此外，已通过
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  日期：2018.3.1

  Noble metals are valued, critical elements whose chemical activation or recycling is challenging, and traditionally requires high temperatures, strong acids or bases, or aggressive complexation agents. By using elementary palladium and gold, demonstrated here is the use of mechanochemistry for noble‐metal activation and recycling by mild, clean, solvent‐free, and room‐temperature chemistry. The process

  贵重金属是重要的关键元素，其化学活化或循环利用具有挑战性，并且传统上需要高温，强酸或强碱或侵蚀性络合剂。通过使用元素钯和金，此处证明了通过温和，清洁，无溶剂和室温化学作用将机械化学用于贵金属活化和回收。该过程可将包括废催化剂在内的金属直接，高效，一锅转换为简单的水溶性盐或金属有机催化剂。
• Dinuclear Cycloaurated Complexes Containing Bridging (2-Diphenylphosphino)phenylphosphine and (2-Diethylphosphino)phenylphosphine, C₆H₄PR₂ (R = Ph, Et). Carbon−Carbon Bond Formation by Reductive Elimination at a Gold(II)−Gold(II) Center
  作者：Martin A. Bennett、Suresh K. Bhargava、David C. R. Hockless、Lee L. Welling、Anthony C. Willis

  DOI：10.1021/ja961511h

  日期：1996.1.1

  The digold(I) complexes Au2(μ-C6H4PR2)2 [R = Ph (1a), Et (1b)] obtained by treatment of AuBr(PEt3) with o-LiC6H4PR2 undergo addition with halogens or benzoyl peroxide to give metal−metal bonded digold(II) complexes Au2X2(μ-C6H4PR2)2 [R = Ph, Et; X = I (2a, 2b), Br (3a, 3b), Cl (4a, 4b), O2CPh (5a, 5b)], which are structurally similar to the bis(ylide) complexes Au2X2μ-(CH2)2PR2}2. The benzoate ligands

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  DOI：10.1016/j.jinorgbio.2012.07.001

  日期：2012.12

  [AuIIIX2(dtc-Sar-Aib3-O(t-Bu))] (X = Br (4a)/Cl (4b)), and [AuIIIX2(dtc-Sar-Aib3-Gly-OEt)] (X = Br (5a)/Cl (5b)) (Aib = “alpha”-aminoisobutyric acid, 2-methylalanine) were designed to obtain metal-based peptidomimetics that may specifically target two peptide transporters (namely, PEPT1 and PEPT2) upregulated in several human tumor cells. All the compounds were characterized by means of FT-IR and mono- and multidimensional

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• Anticancer Gold(III) Peptidomimetics: From Synthesis to in vitro and ex vivo Biological Evaluations
  作者：Giulia Boscutti、Chiara Nardon、Luciano Marchiò、Marco Crisma、Barbara Biondi、Daniele Dalzoppo、Lisa Dalla Via、Fernando Formaggio、Angela Casini、Dolores Fregona

  DOI：10.1002/cmdc.201800098

  日期：2018.6.6

  peptidomimetic ligand toward two peptide transporters (namely PEPT1 and PEPT2), which are upregulated in several tumor cells. The compounds were synthesized and fully characterized, mainly by means of elemental analysis, one‐ and two‐dimensional NMR spectroscopy, FT‐IR, and UV/Vis spectrophotometry. The crystal structures of three compounds were also solved by X‐ray diffraction. In vitro cytotoxicity studies

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