二甲基锗烷硫酮 | 16090-49-6

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 中文名称: 二甲基锗烷硫酮
• 英文名称: dimethylgermanethione
• 英文别名: Dimethyl-germaniumsulfid；Dimethyl germanium sulfide；dimethyl(sulfanylidene)germane
• CAS: 16090-49-6
• 化学式: C₂H₆GeS
• 分子量: 134.726
• InChiKey: FTOAATXNJIOWPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.43
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.1
• 氢给体数：
  0
• 氢受体数：
  1

ADMET

毒理性

• 副作用

神经毒素 - 感觉运动 职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒案例。 肾毒素 - 该化学物质在职业环境中可能对肾脏有毒。

Neurotoxin - Sensorimotor Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 人类毒性摘录

当预期暴露水平较高时，锗对水盐平衡的深刻干扰能力可能对人类有相关性。这会导致血液浓缩、血压下降和低体温。/锗/

One effect which may have human relevance is the profound ability of germanium to disturb water balance when high exposure levels are expected. This leads to hemoconcentration, a fall in blood pressure, and hypothermia. /Germanium/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

动物研究以检测致突变性、致畸性和致癌性没有产生任何阳性证据。/锗/

Animal studies to detect mutagenicity, teratogenicity, and carcinogenicity did not produce any positive evidence. /Germanium/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

锗以各种形式从胃肠道吸收并在给药后24小时内通过尿液（68%）和粪便（9.7%）排出。它在血浆和红细胞之间分布相当均匀，但不与血浆蛋白结合。锗可能在血液中不与蛋白质结合进行运输，因为它在几小时内就会离开血液。它广泛分布在身体组织中，并不被任何单一组织选择性保留。通常在一周内，它甚至从检测到的组织中消失。/锗/

Germanium in various forms is absorbed from the gastrointestinal tract and excreted in the urine (68%) and the feces (9.7%) within 24 hours of administration. It is fairly equally distributed between plasma and red blood cells but is not bound to plasma proteins. Germanium may be transported in the blood, unbound to protein, since it leaves the bloodstream in a few hours. It is widely distributed in body tissue and not selectively retained by any single tissue. Often, within a week it has even disappeared from the tissues in which it was detected. /Germanium/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 海关编码：
  2931900090

反应信息

• 作为反应物：
  描述：

  二甲基锗烷硫酮 以 solid matrix 为溶剂， 生成
  参考文献：
  名称：

  Generation, low-temperature stabilization, structure, and reactivity of intermediates with low-coordinated carbon, silicon, and germanium atoms

  摘要：

  The mechanisms of thermal and photochemical transformations of organic and organometallic compounds which pass through formation of different reactive intermediates were investigated by low-temperature matrix IR spectroscopy. Low-temperature matrix stabilization of the intermediates, the primary products of these reactions, was conducted at 10-15 K. The spectral and structural parameters of the free radicals (CCl3, CCl2Br, CClBr2, CH2CH=CH2, CF2CF=CF2, CH2-C=CH, CH2C=N, CH2Ph, CF2C6F5), halocarbenes and their silicon and germanium analogs, and unstable molecules with double-bond silicon and germanium atoms were obtained as a result.

  DOI：

  10.1007/bf00961022
• 作为产物：
  描述：

  hexamethylcyclotrigermatrithiane 以 neat (no solvent) 为溶剂， 生成 二甲基锗烷硫酮
  参考文献：
  名称：

  锗烷乙炔Me2Ge：S的基质分离和红外光谱

  摘要：

  DOI：

  10.1021/om00110a033

文献信息

• Direct study of unstable dimethylgermathione, Me2GeS, by vacuum pyrolysis-MS and low temperature matrix IR spectroscopy
  作者：V.N. Khabashesku、S.E. Boganov、P.S. Zuev、O.M. Nefedov、J. Tamás、A. Gömöry、I. Besenyei

  DOI：10.1016/0022-328x(91)83060-h

  日期：1991.1

  Dimethylgermathione, Me2GeS (D1), has been studied by vacuum pyrolysis-MS and matrix isolation IR spectroscopy. The germathione D1 was generated in the gas phase by pyrolytic decomposition (730–900°C, 10−2 −10−3 Torr) of the trimer (Me2GeS)3 (D3) in a quartz pyrolyzer, coupled to the ionization chamber of mass spectrometer or to an optical helium cryostat, where pyrolysis products have been frozen

  Dimethylgermathione中，Me 2个GeS（d 1），已经研究了通过真空热解-MS和基质隔离IR光谱。杀菌剂D 1是在石英热解器中通过三聚体（Me 2 GeS）3（D 3）的热解分解（730-900°C，10 -2 -10 -3托）在气相中产生的。质谱仪的电离室或光学氦低温恒温器，其中热解产物已在12 K的氩气基质中冷冻。
• Barrau, J.; Rima, G.; Satge, J., Phosphorus, Sulfur and Silicon and the Related Elements, 1995, vol. 107, # 1-4, p. 99 - 106
  作者：Barrau, J.、Rima, G.、Satge, J.

  DOI：——

  日期：——
• Germanones ET germathiones: Réactivité vis-à-vis de petits cycles organiques
  作者：Jacques Barrau、Ghassoub Rima、Hélène Lavayssière、Gabriel Dousse、Jacques Satgé

  DOI：10.1016/s0022-328x(00)98729-1

  日期：1983.4
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Ge: SVol., 128, page 554 - 556
  作者：

  DOI：——

  日期：——
• Lavayssiere, Helene; Dousse, Gabriel; Satge, Jacques, Angewandte Chemie, 1982, vol. 94, p. 455 - 455
  作者：Lavayssiere, Helene、Dousse, Gabriel、Satge, Jacques、Barrau, Jacques、Traore, Moussa

  DOI：——

  日期：——