Diisobutylselenit | 10105-56-3

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: Diisobutylselenit
• 英文别名: Bis(2-methylpropyl) selenite
• CAS: 10105-56-3
• 化学式: C₈H₁₈O₃Se
• 分子量: 241.189
• InChiKey: MMFSWASWSXWRMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.75
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Diisobutylselenit 在 氯 作用下， 以 四氯化碳 为溶剂， 生成 dichloro-diisobutoxy-λ⁴-selane
  参考文献：
  名称：

  Mehrotra,R.C.; Mathur,S.N., Indian Journal of Chemistry, 1967, vol. 5, p. 375 - 378

  摘要：

  DOI：
• 作为产物：
  描述：

  异丁醇 在 selenium(IV) oxide 作用下， 生成 Diisobutylselenit
  参考文献：
  名称：

  Production and Application of Polyclonal Antibody to Human Thyroid Transcription Factor 2 Reveals Thyroid Transcription Factor 2 Protein Expression in Adult Thyroid and Hair Follicles and Prepubertal Testis

  摘要：

  Germline mutations in thyroid transcription factor 2 (TTF2) cause thyroid agenesis, spiky hair, and cleft palate, indicating thyroidal and extrathyroidal expression. We sought to investigate this by producing and applying an antibody to human TTF2. The coding region of human TTF2 was cloned into a bacterial expression vector, production of the soluble TTF2 protein optimized, and pure TTF2 obtained by nickel chromatography. Rabbits were immunized and the resulting TTF2 polyclonal titrated on formalin-fixed, paraffin-embedded sections of thyroid. The optimized protocol was applied to a range of tissues. Nine milligrams of TTF2 protein was obtained per liter of culture and a high-titer antibody produced. This displayed specific staining of thyroid follicular cell nuclei/cytoplasm and not of the interstitium, connective tissue, smooth muscle, or endothelium. No staining was obtained with the preimmune serum in the same conditions, or with the majority of other tissues tested with the TTF2 polyclonal. The exceptions were testis and skin, in which nuclear TTF2 immunoreactivity was present in the seminiferous tubules and cells in the follicular outer root sheath, respectively. In conclusion, we have produced a polyclonal antibody for human TTF2 and demonstrated immunoreactivity for this transcription factor in adult human thyroid and hair follicles and prepubertal testis.

  DOI：

  10.1089/105072503322511328

文献信息

• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Se: MVol.B, 21, page 40 - 43
  作者：

  DOI：——

  日期：——
• Mel'nikov, N. N.; Rokickaja, M. S., Zhurnal Obshchei Khimii, 1937, vol. 7, p. 1532 - 1532
  作者：Mel'nikov, N. N.、Rokickaja, M. S.

  DOI：——

  日期：——
• Mehrotra,R.C.; Mathur,S.N., Journal of the Indian Chemical Society, 1964, vol. 41, p. 111 - 115
  作者：Mehrotra,R.C.、Mathur,S.N.

  DOI：——

  日期：——