2-chloro-5-phthalidyl-benzenesulfonic acid amide | 82875-52-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 2-chloro-5-phthalidyl-benzenesulfonic acid amide
• 英文别名: 2-Chlor-5-phthalidyl-benzolsulfonsaeure-amid；3-(3'-sulfamyl-4'-chlorophenyl)-3H-phthalide；2-chloro-5-(3-oxo-1H-2-benzofuran-1-yl)benzenesulfonamide
• CAS: 82875-52-3
• 化学式: C₁₄H₁₀ClNO₄S
• 分子量: 323.757
• InChiKey: GHZYUSYXOALWEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  94.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 乙醇 、 锌 作用下， 生成 2-chloro-5-phthalidyl-benzenesulfonic acid amide
  参考文献：
  名称：

  用于二苯甲酮-2-羧酸衍生物的构成†

  摘要：

  一些二苯甲酮-2-羧酸

  DOI：

  10.1002/hlca.19590420344

文献信息

• Process for forming certain substituted phthalimidines
  申请人：USV Pharmaceutical Corporation

  公开号：US04477675A1

  公开（公告）日：1984-10-16

  The process of preparing a compound of the formula: ##STR1## wherein, Y and Z are each H, alkyl, halo, alkoxy, trifluoromethyl, hydroxy, alkanoyloxy, or alkanoylamino; X is F, Cl, Br, or NR.sub.1 R.sub.2 wherein R.sub.1 and R.sub.2 are each hydrogen, alkyl, alkynyl, alkenyl, cycloalkyl, aryl or aralkyl; and R is H, alkyl, cycloalkyl, or aralkyl; which comprises the step of oxidation of the corresponding 3-desoxy compound.

  制备化合物的过程：##STR1## 其中，Y和Z分别为H，烷基，卤素，烷氧基，三氟甲基，羟基，烷酰氧基或烷酰氨基; X为F、Cl、Br或NR.sub.1 R.sub.2，其中R.sub.1和R.sub.2分别为氢、烷基、炔基、烯基、环烷基、芳基或芳基烷基; R为H、烷基、环烷基或芳基烷基；其包括对应的3-去氧化合物的氧化步骤。
• Intermediates for the synthesis of phthalimidines
  申请人：USV Pharmaceutical Corporation

  公开号：US04331600A1

  公开（公告）日：1982-05-25

  Compounds of the formula ##STR1## wherein, Y and Z are each H, alkyl, halo, alkoxy, trifluoromethyl, hydroxy, alkanoyloxy, or alkanoylamino; X is F, Cl Br or NR.sub.1 R.sub.2 in which R.sub.1 and R.sub.2 are each hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl or cycloalkyl; and R is H, alkyl, cycloalkyl or aralkyl; and salts thereof. The compounds have utility as anti-hypertensive and diuretic agents and as intermediates for the preparation of other anti-hypertensive and diuretic agents.

  化合物的化学式为##STR1##其中，Y和Z分别为H，烷基，卤素，烷氧基，三氟甲基，羟基，烷酰氧基或烷酰胺基；X为F，Cl，Br或NR.sub.1R.sub.2，其中R.sub.1和R.sub.2分别为氢，烷基，烯基，炔基，芳基，芳基烷基或环烷基；R为H，烷基，环烷基或芳基烷基；及其盐。这些化合物可用作抗高血压和利尿剂，并用作制备其他抗高血压和利尿剂的中间体。
• Oxidation process
  申请人：USV PHARMACEUTICAL CORPORATION

  公开号：EP0051217A1

  公开（公告）日：1982-05-12

  This invention relates to a new and useful process for the preparation of certain phthalimidines and more particularly with the preparation of 3-aryl-3-hydroxyphthalimidines which are useful astherapeutic agents.. The 3-aryl-3-hydroxyphthalimidines produced in accordance with the present invention are compounds of the formula: wherein, Y and Z are each H, alkyl, halo, alkoxy, trifluoromethyl, hydroxy, alkanoyloxy, or alkanoylamino; X is F, Cl, Br, or NR1R2 in which R1 and R2 are each hydrogen, alkyl, alkynyl, alkenyl, cycloalkyl, aryl or aralkyl; and, R is H, alkyl, cycloalkyl, or aralkyl.

  本发明涉及一种新的、有用的制备某些邻苯二甲酰亚胺的方法，更具体地涉及制备3-芳基-3-羟基邻苯二甲酰亚胺，该化合物是一种有用的治疗剂。根据本发明制备的3-芳基-3-羟基邻苯二甲酰亚胺是以下式的化合物：其中，Y和Z分别为H、烷基、卤素、烷氧基、三氟甲基、羟基、烷酰氧基或烷酰氨基；X为F、Cl、Br或NR1R2，其中R1和R2分别为氢、烷基、炔基、烯基、环烷基、芳基或芳基烷基；R为H、烷基、环烷基或芳基烷基。
• Methods and intermediates for the synthesis of 3-aryl-3-hydroxy-phthalimidines
  申请人：USV PHARMACEUTICAL CORPORATION

  公开号：EP0051215A2

  公开（公告）日：1982-05-12

  This invention relates to new intermediates for the preparation of certain phthalimidines and phthalazinones. The intermediates are more particularly concerned with the preparation of 3-aryl-3-hydroxyphthalimidines which are useful as therapeutic agents. The 3-aryl-3-hydroxyphthalimidines produced in accordance with the present invention are compounds of the formula: wherein, Y and Z are each H, alkyl, halo, alkoxy, trifluoromethyl, hydroxy, alkanoyloxy, or alkanoylamino; X is F, Cl, Br or NR1R2 in which R1 and R2 are each hydrogen, alkyl, alkynyl, alkenyl, cycloalkyl, aryl or aralkyl; and R is H, alkyl, cycloalkyl, or aralkyl.

  本发明涉及用于制备某些酞亚胺和酞嗪酮的新中间体。这些中间体尤其与制备 3-芳基-3-羟基邻苯二甲酰亚胺有关，这些邻苯二甲酰亚胺可用作治疗剂。 根据本发明生产的 3-芳基-3-羟基邻苯二甲酰亚胺是式中的化合物： 其中 Y和Z各自是H、烷基、卤代、烷氧基、三氟甲基、羟基、烷酰氧基或烷酰氨基； X 是 F、Cl、Br 或 NR1R2，其中 R1 和 R2 各自是氢、烷基、炔基、烯 基、环烷基、芳基或芳烷基；以及 R 是 H、烷基、环烷基或芳烷基。
• US4331600A
  申请人：——

  公开号：US4331600A

  公开（公告）日：1982-05-25