tributylfluorosilane | 338-49-8

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: tributylfluorosilane
• 英文别名: Tributyl-fluor-silan；Tributyl(fluoro)silane
• CAS: 338-49-8
• 化学式: C₁₂H₂₇FSi
• 分子量: 218.43
• InChiKey: STAGZMKHHNNCKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  tributylfluorosilane 生成 ethoxy-tributyl-silane
  参考文献：
  名称：

  Malignant Peripheral Nerve Sheath Tumors with t(X;18). A Pathologic and Molecular Genetic Study

  摘要：

  Spindle cell sarcomas often present the surgical pathologist with a considerable diagnostic challenge. Malignant peripheral nerve sheath tumor, leiomyosarcoma, fibrosarcoma, and monophasic synovial sarcoma may all appear similar histologically. The application of ancillary diagnostic modalities, such as immunohistochemistry and electron microscopy, may be helpful in the differentiation of these tumors, but in cases in which these adjunctive: techniques fail to demonstrate any more definitive evidence of differentiation, tumor categorization may remain difficult. Cytogenetic and molecular genetic characterization of tumors have provided the basis for the application of molecular assays as the newest components of the diagnostic armamentarium. Because the chromosomal translocation t(X;18) has been observed repeatedly in many synovial sarcomas, it has been heralded as a diagnostic hallmark of synovial sarcoma To formally test the specificity of this translocation for the diagnosis of synovial sarcoma, RNA extracted from formalin-fixed, parrafin-embedded tissue from a variety of soft tissue and spindle cell tumors was evaluated fbr the presence of t(X;18) by reverse transcriptase-polymerase chain reaction. Although 85% of the synovial sarcomas studied demonstrated t(X;18), 75% of the malignant peripheral nerve sheath tumors in our cohort also demonstrated this translocation. We conclude that the translocation t(X;18) is not specific to synovial sarcoma and discuss the implications of the demonstration of t(X;18) in a majority of malignant peripheral nerve sheath tumors.

  DOI：

  10.1038/modpathol.3880230
• 作为产物：
  描述：

  三丁基氯硅烷 在 氢氟酸 作用下， 生成 tributylfluorosilane
  参考文献：
  名称：

  Pearlson; Brice; Simons, Journal of the American Chemical Society, 1945, vol. 67, p. 1770

  摘要：

  DOI：

文献信息

• Rhodium-Catalyzed Synthesis of Diaryl Sulfides Using Aryl Fluorides and Sulfur/Organopolysulfides
  作者：Mieko Arisawa、Takuya Ichikawa、Masahiko Yamaguchi

  DOI：10.1021/ol302497m

  日期：2012.10.19

  Substituted pentafluorobenzenes react with sulfur to give bis(4-substituted 2,3,5,6-tetrafluorophenyl) sulfides in the presence of RhH(PPh3)4, 1,2-bis(diphenylphosphino)benzene (dppBz), and tributylsilane. The reaction proceeds efficiently between room temperature and 80 °C. A comparative study of the reactivities of an organic trisulfide and a tetrasulfide showed notable substrate specificity. Di-tert-butyl

  取代pentafluorobenzenes与硫反应以得到在RhH的存在双（4-取代的2,3,5,6-四氟苯基）硫化物（PPH 3）4，1,2-双（二苯基膦基）苯（dppBz），和三丁基。反应在室温至80°C之间有效进行。对有机三硫化物和四硫化物的反应性进行的比较研究显示出显着的底物特异性。二-叔-丁基四硫化物具有反应性的芳基一氟化物和取代pentafluorobenzenes反应。二-叔丁基三硫化物与芳基一氟化物反应。根据S–S键能的差异解释了反应性。
• Petrow; Schtschukowskaja, Zhurnal Obshchei Khimii, 1955, vol. 25, p. 1128,1134;engl.Ausg.S.1083,1087
  作者：Petrow、Schtschukowskaja

  DOI：——

  日期：——
• Preparation of Organofluorosilanes Using Aqueous Hydrofluoric Acid¹
  作者：N. S. Marans、L. H. Sommer、F. C. Whitmore

  DOI：10.1021/ja01155a033

  日期：1951.11
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Si: MVol.C, 74, page 207 - 208
  作者：

  DOI：——

  日期：——
• Organic Reactions with Silicon Compounds.¹ II. The Reaction of Silicon Tetrafluoride with the Grignard Reagent
  作者：J. A. Gierut、F. J. Sowa、J. A. Nieuwland

  DOI：10.1021/ja01297a013

  日期：1936.6