(3Z)-3-[[[4-(3,4-dihydroxyphenyl)-1,3-thiazol-2-yl]amino]methylidene]chromene-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (3Z)-3-[[[4-(3,4-dihydroxyphenyl)-1,3-thiazol-2-yl]amino]methylidene]chromene-2,4-dione
• 化学式: C₁₉H₁₂N₂O₅S
• 分子量: 380.4
• InChiKey: GDLAPCMFJZNZHI-WQLSENKSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  137
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• RIBONUCLEOTIDE REDUCTASE INHIBITORS AND METHODS OF USE
  申请人：City of Hope

  公开号：US20180155303A1

  公开（公告）日：2018-06-07

  Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme, as well as methods of synthesizing these novel compounds. The compounds may be used to inhibit RR activity and to treat various conditions associated with RRM2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases.

  本文提供了一些新化合物，它们通过结合RRM2并干扰RRM1/RRM2全酶的活性来抑制核糖核苷酸还原酶（RR）的活性，同时还提供了合成这些新化合物的方法。这些化合物可用于抑制RR的活性，并用于治疗与RRM2表达有关的各种疾病，例如某些癌症类型、线粒体疾病或退行性疾病。
• SMALL MOLECULE INHIBITORS OF BACTERIAL DAM DNA METHYLTRANSFERASES
  申请人：Cheng Xiaodong

  公开号：US20100035945A1

  公开（公告）日：2010-02-11

  Disclosed are compounds, crystal structures, data representations, methods of using, and methods of identifying compounds in relation to DNA methylation and inhibition of methylation. In embodiments, DNA methylation is by DNA-adenine methyltransferases (Dam). In an embodiment, compounds are used to treat a host suspected of infection by a pathogenic organism. In an embodiment, virulence of a pathogenic bacterium is modified by treatment with an agent capable of inhibiting a bacterial Dam enzyme. In an embodiment, compounds and methods are disclosed regarding Dam inhibitors.
• US7956076B2
  申请人：——

  公开号：US7956076B2

  公开（公告）日：2011-06-07
• US8163783B2
  申请人：——

  公开号：US8163783B2

  公开（公告）日：2012-04-24
• US8372983B2
  申请人：——

  公开号：US8372983B2

  公开（公告）日：2013-02-12