N-甲基-1-(哌啶-2-基)甲胺 | 27643-19-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: N-甲基-1-(哌啶-2-基)甲胺
• 中文别名: 2-[(甲基氨基)甲基]哌啶
• 英文名称: 2-Methylaminomethyl-piperidin
• 英文别名: Pipecolyl-methylamin；N-Methyl-1-(piperidin-2-yl)methanamine；N-methyl-1-piperidin-2-ylmethanamine
• CAS: 27643-19-2
• 化学式: C₇H₁₆N₂
• 分子量: 128.217
• InChiKey: MGOVUZGBXAFMCY-UHFFFAOYSA-N

物化性质

• 沸点：
  176℃
• 密度：
  0.861
• 闪点：
  55℃

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  N-甲基-1-(哌啶-2-基)甲胺 在 氯化亚砜 、 三乙胺 作用下， 以 氯仿 为溶剂， 生成 2-methyl-hexahydro-[1,2,5]thiadiazolo[2,3-a]pyridine 1-oxide
  参考文献：
  名称：

  WINTERFELD; HAERING, Archiv der Pharmazie, 1962, vol. 295 /67, p. 621 - 624

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 lithium aluminium tetrahydride 作用下， 生成 N-甲基-1-(哌啶-2-基)甲胺
  参考文献：
  名称：

  Synthese von 2-Azaindolizidin und 2,3-substituierten Abk�mmlingen

  摘要：

  DOI：

  10.1007/bf00635564
• 作为试剂：
  描述：

  4-叔丁基苯硼酸 、 S-叔丁基亚磺酰胺 在 N-甲基-1-(哌啶-2-基)甲胺 、 氯化镍二甲氧基乙烷 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙腈 为溶剂， 以72%的产率得到
  参考文献：
  名称：

  优化的 Ni 催化 Chan-Lam 型偶联：对映体获得手性 N-芳基亚磺酰胺

  摘要：

  优化了优化的 Ni 催化的 Chan-Lam 型偶联反应。制备了一系列手性 N-芳基亚磺酰胺，化学收率高，没有任何外消旋化。提出了一种似是而非的新颖机制，该方法可用于有效制备各种 C-X 键。

  DOI：

  10.1002/chem.202202190

文献信息

• PYRAZOLE DERIVATIVES
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP1762568A1

  公开（公告）日：2007-03-14

  A compound represented by formula (I): (wherein Ar1 represents a phenyl group which may have 1 to 3 substituents, or a non-substituted 5- or 6-membered aromatic heterocyclic group; Ar2 represents (i) a non-substituted phenyl group, (ii) a phenyl group which has been substituted by a lower alkyl group having 1 to 3 groups or atoms selected from among a carbamoyl group, an amino group, a hydroxyl group, a lower alkoxy group, and a halogen atom, or (iii) a 5- or 6-membered nitrogen-containing aromatic heterocyclic group which has been substituted by 1 to 3 groups or atoms selected from among a lower alkyl group, a lower alkynyl group, a lower alkanoyl group, a carbamoyl group, a cyano group, an amino group, a hydroxyl group, a lower alkoxy group, and a halogen atom; and X represents a group represented by formula (II): (wherein the ring structure represents a 4- to 7-membered heterocyclic group which may have, in addition to the nitrogen atom shown in formula (II), one heteroatom selected from among nitrogen, oxygen, and sulfur, and which may be substituted by 1 to 4 groups or atoms selected from among a lower alkyl group, a carbamoyl group, an amino group, a hydroxyl group, a lower alkoxy group, an oxo group, a lower alkanoyl group, a lower alkylsulfonyl group, and a halogen atom)), a salt thereof, a solvate of the compound or the salt, and a drug.

  由式(I)表示的化合物： （其中Ar1代表可能具有1到3个取代基的苯基，或者是非取代的5-或6-成员芳香杂环基团；Ar2代表（i）非取代的苯基团，（ii）已被1到3个来自羰胺基、氨基、羟基、低烷氧基和卤原子的群或原子取代的较低烷基基团取代的苯基团，或者（iii）已被1到3个来自低烷基基团、低炔基基团、低烷酰基团、羰胺基、氰基、氨基、羟基、低烷氧基和卤原子的群或原子取代的5-或6-成员含氮芳香杂环基团；X代表由式(II)表示的基团： （其中环结构表示可能具有除了式(II)中显示的氮原子之外，从氮、氧和硫中选择的一个杂原子的4-到7-成员杂环基团，并且可能被1到4个来自低烷基基团、羰胺基、氨基、羟基、低烷氧基、氧基、低烷酰基团、低烷基磺酰基团和卤原子的群或原子取代）），其盐，该化合物或其盐的溶剂化合物，以及药物。
• 8-Substituted isoquinoline derivative and the use thereof
  申请人：Kaneko Shunsuke

  公开号：US20100261701A1

  公开（公告）日：2010-10-14

  The present invention relates to a compound represented by the following formula (1): wherein D 1 , A 1 , D 2 , R 1 , D 3 , and R 2 each have the same meaning as defined in the present specification or a salt thereof. The compound represented by the formula (1) or a salt thereof has an IKKβ inhibiting activity and the like and is useful for the prevention and/or treatment of IKKβ-associated diseases or symptoms and the like.

  本发明涉及一种由以下式（1）表示的化合物： 其中D1，A1，D2，R1，D3和R2分别具有与本说明书中定义的相同含义或其盐。由式（1）表示的化合物或其盐具有IKKβ抑制活性等，对于预防和/或治疗IKKβ相关疾病或症状等方面是有用的。
• 2,6-BIS-(AMINOMETHYL)PIPERIDINE DERIVATIVES
  申请人：BASF SE

  公开号：US20150353491A1

  公开（公告）日：2015-12-10

  The present invention relates to 2,6-bis(aminomethyl)piperidine derivatives as such (in the following text abbreviated to “2,6-BAMP derivatives”) which are defined by the general formula (I) shown in the following text. In addition, the present invention relates to a process for preparing such 2,6-BAMP derivatives by hydrogenation of the corresponding 2,6-dicyanopiperidine derivatives (hereinafter abbreviated to “2,6-DCP derivatives”) in the presence of a catalyst. The present invention further provides for the use of the 2,6-BAMP derivatives of the invention as hardeners for epoxy resins, as intermediate in the preparation of diisocyanates, which play an important role in the production of polyurethanes, as starters in the preparation of polyetherols and/or as monomers for polyamide production. The present invention further relates to the diisocyanates as such prepared from the 2,6-BAMP derivatives and also the corresponding preparative process.

  本发明涉及2,6-双(氨甲基)哌啶衍生物（以下简称为“2,6-BAMP衍生物”），其由下文所示的通式（I）定义。此外，本发明涉及一种通过在催化剂存在下对相应的2,6-二氰基哌啶衍生物（以下简称为“2,6-DCP衍生物”）进行氢化制备此类2,6-BAMP衍生物的方法。本发明还提供了本发明的2,6-BAMP衍生物作为环氧树脂的固化剂、作为制备二异氰酸酯的中间体，在聚氨酯生产中扮演重要角色、作为制备聚醚醇的起始剂和/或作为聚酰胺生产的单体的用途。本发明还涉及从2,6-BAMP衍生物制备的二异氰酸酯及相应的制备过程。
• Process for Production of Optically Active Quinuclidinols
  申请人：Noyori Ryoji

  公开号：US20090216019A1

  公开（公告）日：2009-08-27

  A novel ruthenium complex which is a highly efficient catalyst useful for the production of optically active 3-quinuclidinols, and a process for production of optically active 3-quinuclidinols using the ruthenium complex as a catalyst, where the optically active 3-quinuclidinols are useful as an optically active, physiologically active compound utilized in medicines and agrichemicals or as a synthetic intermediate such as a liquid crystal material.

  一种新颖的钌配合物，是一种高效催化剂，可用于生产光学活性的3-喹诺啉醇，并且提供一种以该钌配合物为催化剂生产光学活性3-喹诺啉醇的方法，其中光学活性的3-喹诺啉醇可用作光学活性、生理活性的化合物，用于药物和农药，或者作为合成中间体，如液晶材料。
• NEW COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
  申请人：ROTH Gerald Juergen

  公开号：US20120157425A1

  公开（公告）日：2012-06-21

  The invention relates to new piperidine derivatives of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

  该发明涉及新的哌啶衍生物，其化学式I，用作药物，用于治疗的方法以及含有它们的药物组合物。