荧光素-二棕榈酰磷脂酰乙醇胺 | 87706-98-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 荧光素-二棕榈酰磷脂酰乙醇胺
• 英文名称: Fluorescein-Dipalmitoylphosphatidylethanolamine
• 英文别名: [(2R)-3-[2-[(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-yl)carbamothioylamino]ethoxy-hydroxyphosphoryl]oxy-2-hexadecanoyloxypropyl] hexadecanoate
• CAS: 87706-98-7
• 化学式: C₅₈H₈₅N₂O₁₃PS
• 分子量: 1081.3
• InChiKey: LZNPLDBLBWZYIW-QZNUWAOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16.3
• 重原子数：
  75
• 可旋转键数：
  41
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  241
• 氢给体数：
  5
• 氢受体数：
  14

文献信息

• MAGNETIC-BASED BIOPANNING METHOD THROUGH ATTACHMENT OF MAGNETIC BEAD TO CELL
  申请人：AIMED BIO INC.

  公开号：EP3798305A1

  公开（公告）日：2021-03-31

  The present invention relates to a method for screening an antibody or antigen-binding fragment thereof by using cells bearing magnetic beads and, more particularly, to a method for screening an antibody binding specifically to an antigen protein or an antigen-binding fragment thereof, in which cells having biotinylated phospholipids in the cell membranes thereof and a streptavidin-magnetic bead complex fused to the surfaces thereof, and a magnetic-based system are utilized.

  本发明涉及一种利用带有磁珠的细胞筛选抗体或其抗原结合片段的方法，更具体地说，涉及一种筛选与抗原蛋白或其抗原结合片段特异性结合的抗体的方法，其中利用了在其细胞膜上具有生物素化磷脂的细胞和融合在其表面的链霉亲和素-磁珠复合物以及基于磁性的系统。
• INTRANASAL DELIVERY OF FLUORESCENT MARKER
  申请人：UCL BUSINESS LTD

  公开号：EP3784293A1

  公开（公告）日：2021-03-03
• METHODS AND COMPOSITIONS FOR STIMULATION OF CHIMERIC ANTIGEN RECEPTOR T CELLS WITH HAPTEN LABELLED CELLS
  申请人：Seattle Children's Hospital (DBA Seattle Children's Research Institute)

  公开号：EP4100026A1

  公开（公告）日：2022-12-14
• Intranasal Delivery of Fluorescent Marker
  申请人：UCL Business LTD

  公开号：US20210228745A1

  公开（公告）日：2021-07-29

  The present invention provides a method of diagnosing a CNS disorder comprising administering a fluorescent marker of retinal integrity to a subject and generating an image of the subject's eye, wherein the fluorescent marker is delivered by intranasal administration is also provided and fluorescent markers of retinal integrity for use in such methods. Also provided is a pharmaceutical composition comprising an annex in or a functional fragment or derivative thereof conjugated to a compound of 2 kDa or less, wherein the composition comprises annex in or a functional fragment or derivative thereof conjugated at a concentration of at least mg/ml.
• [EN] METHODS FOR AMPLIFYING IMMUNOASSAY SIGNALS<br/>[FR] MÉTHODES D'AMPLIFICATION DE SIGNAUX D'IMMUNOESSAI
  申请人：SIEMENS HEALTHCARE DIAGNOSTICS INC

  公开号：WO2021178988A1

  公开（公告）日：2021-09-10

  Disclosed herein are methods for using modified liposomes or carrier proteins comprising (i) an acridinium ester (AE), and (ii) a first agent encapsulated by the liposomes and/or (iii) a second agent on the surface of the liposomes or the carrier proteins. Specifically, the disclosed methods provide methods of labeling a target of interest, assaying a biological sample for a target antigen, and detecting a target antigen in a biological sample. Further disclosed herein are methods for increasing the strength of a signal detected by an imaging modality.