tert-Butyl-carbamic acid naphthalen-1-yl ester | 34197-72-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: tert-Butyl-carbamic acid naphthalen-1-yl ester
• 英文别名: naphthalen-1-yl N-tert-butylcarbamate
• CAS: 34197-72-3
• 化学式: C₁₅H₁₇NO₂
• 分子量: 243.305
• InChiKey: NMPVKRZWKPKSLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-萘基氰酸酯 、 叔丁醇 在 硫酸 作用下， 以 乙醚 为溶剂， 生成 tert-Butyl-carbamic acid naphthalen-1-yl ester
  参考文献：
  名称：

  Grochowski,E.; Tomasik,W., Bulletin de l'Academie Polonaise des Sciences, Serie des Sciences Chimiques, 1971, vol. 19, p. 371 - 375

  摘要：

  DOI：

文献信息

• Novel carbamate and oxamide compounds
  申请人：Boehringer Ingelheim Pharmaceuticals, Inc.

  公开号：US20030092702A1

  公开（公告）日：2003-05-15

  Disclosed are novel aromatic compounds of the formula(I) described herein, wherein G, E, W, Ar, X, Y and Z are disclosed herein. The compounds are useful for treating cytokine mediated diseases or conditions such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds. 1

  本文披露了一种新型芳香化合物，其化学式为(I)，其中G、E、W、Ar、X、Y和Z如本文所述。这些化合物可用于治疗细胞因子介导的疾病或病况，如慢性炎症性疾病。还披露了含有这些化合物的药物组合物和制备这些化合物的方法。
• Compounds useful as anti-inflammatory agents
  申请人：——

  公开号：US20020032195A1

  公开（公告）日：2002-03-14

  Disclosed are novel aromatic compounds of the formula(I) wherein G, E, W, Ar, X, Y and Z. The compounds are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds. 1

  揭示了一种新颖的芳香化合物，其化学式为(I)，其中G、E、W、Ar、X、Y和Z。这些化合物可用于治疗涉及炎症的疾病或病理条件，如慢性炎症性疾病。还揭示了含有这些化合物的药物组合物以及制备这些化合物的方法。
• Intermediate arylamine compounds
  申请人：Boehringer Ingelheim Pharmaceuticals, Inc.

  公开号：US20030225077A1

  公开（公告）日：2003-12-04

  Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are and pharmaceutical compositions containing, intermediate compounds and processes of making such compounds.

  本发明涉及一种新型芳香化合物，可用于治疗涉及炎症的疾病或病理状况，如慢性炎症性疾病。还公开了含有该化合物的制药组合物、中间体化合物和制备该化合物的过程。
• Heterocyclic urea and related compounds useful as anti-inflammatory agents
  申请人：BOEHRINGER INGELHEIM PHARMACEUTICALS INC.

  公开号：EP1466906A1

  公开（公告）日：2004-10-13

  Disclosed are novel aromatic compounds which are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.

  所公开的新型芳香族化合物可用于治疗涉及炎症（如慢性炎症性疾病）的疾病或病理状况的药物组合物中。还公开了制造此类化合物的工艺。
• HETEROCYCLIC UREA AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS
  申请人：BOEHRINGER INGELHEIM PHARMACEUTICALS INC.

  公开号：EP1165516A2

  公开（公告）日：2002-01-02