1-(2,2-Diphenyl-ethyl)-2-fluoro-benzene | 1229-66-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-(2,2-Diphenyl-ethyl)-2-fluoro-benzene
• 英文别名: Ethane, 1,1-diphenyl-2-(o-fluorophenyl)-；1-(2,2-diphenylethyl)-2-fluorobenzene
• CAS: 1229-66-9
• 化学式: C₂₀H₁₇F
• 分子量: 276.353
• InChiKey: FBFAHMMNPXJBOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-p-tosyl-DL-2-fluorophenylalanine 在 硫酸 作用下， 以 苯 为溶剂， 反应 8.0h， 以28%的产率得到1-fluoro-6-(2-fluorophenyl)naphthalene
  参考文献：
  名称：

  Formation of 2-arylnaphthalenes from N-tosylated phenylalanine derivatives

  摘要：

  N-Tosylated phenylalanine derivatives in benzene in the presence of sulfuric acid afforded 2-arylnaphthalene derivatives in moderate yields. The reaction might proceed via the corresponding decarbonylated N-tosylimine derivatives. Aldol type reaction of N-tosylimines followed by intramolecular Friedel-Crafts reaction and elimination of p-toluenesulfonamide gave 2-arylnaphthalenes. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01507-x

文献信息

• Formation of 2-arylnaphthalenes from N-tosylated phenylalanine derivatives
  作者：Mi Ra Seong、Hyun Nam Song、Jae Nyoung Kim

  DOI：10.1016/s0040-4039(98)01507-x

  日期：1998.9

  N-Tosylated phenylalanine derivatives in benzene in the presence of sulfuric acid afforded 2-arylnaphthalene derivatives in moderate yields. The reaction might proceed via the corresponding decarbonylated N-tosylimine derivatives. Aldol type reaction of N-tosylimines followed by intramolecular Friedel-Crafts reaction and elimination of p-toluenesulfonamide gave 2-arylnaphthalenes. (C) 1998 Elsevier Science Ltd. All rights reserved.