N-[5-[3-(4-methyl-5-oxooxadiazolidin-2-yl)-5-(trifluoromethyl)pyrazol-1-yl]pyridin-2-yl]naphthalene-2-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[5-[3-(4-methyl-5-oxooxadiazolidin-2-yl)-5-(trifluoromethyl)pyrazol-1-yl]pyridin-2-yl]naphthalene-2-carboxamide
• 化学式: C₂₃H₁₇F₃N₆O₃
• 分子量: 482.4
• InChiKey: UOPJQNSQJXGBGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• SUBSTITUTED PYRAZOLE COMPOUNDS AS CRAC MODULATORS
  申请人：Lupin Limited

  公开号：EP2844656A1

  公开（公告）日：2015-03-11
• NOVEL EFFECTIVE ANTIVIRAL COMPOUNDS AND METHODS USING SAME
  申请人：THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：US20170114060A1

  公开（公告）日：2017-04-27

  The present invention includes compounds that are useful in preventing or treating viral infections caused by an enveloped RNA virus, such as viral infections caused by a Filovirus, arenavirus, rhabdovirus, paramyxovirus, orthomyxovirus and/or retrovirus. The present invention further includes compositions comprising such compounds, and methods of treating a viral infection in a subject using such compounds.
• [EN] SUBSTITUTED PYRAZOLE COMPOUNDS AS CRAC MODULATORS<br/>[FR] COMPOSÉS SUBSTITUÉS DE PYRAZOLE EN TANT QUE MODULATEURS DE CRAC
  申请人：LUPIN LTD

  公开号：WO2013164773A1

  公开（公告）日：2013-11-07

  The present invention relates to compounds described herein Formula (I) and pharmaceutical acceptable salts thereof, which modulate the activity of calcium release- activated calcium (CRAC) channel. The invention also describes the compounds of Formula (I) and pharmaceutical compositions containing such compounds thereof for treating, managing, and/or lessening the severity of diseases, disorders, syndromes or conditions associated with the modulation of calcium release-activated calcium (CRAC) channel.
• [EN] NOVEL EFFECTIVE ANTIVIRAL COMPOUNDS AND METHODS USING SAME<br/>[FR] NOUVEAUX COMPOSÉS ANTIVIRAUX EFFICACES ET LEURS MÉTHODES D'UTILISATION
  申请人：UNIV PENNSYLVANIA

  公开号：WO2015187827A1

  公开（公告）日：2015-12-10

  The present invention includes compounds that are useful in preventing or treating viral infections caused by an enveloped RNA virus, such as viral infections caused by a filovirus, arenavirus, rhabdovirus, paramyxovirus, orthomyxovirus and/or retrovirus. The present invention further includes compositions comprising such compounds, and methods of treating a viral infection in a subject using such compounds.
• [EN] METHODS AND COMPOSITIONS FOR TREATING ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR TRAITER UNE LÉSION PULMONAIRE AIGUË ET UN SYNDROME DE DÉTRESSE RESPIRATOIRE AIGUË
  申请人：CALCIMEDICA INC

  公开号：WO2021189013A1

  公开（公告）日：2021-09-23

  Compositions and methods related to the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) including viral pneumonia through the pharmaceutical manipulation of calcium signaling are disclosed. Such compositions and methods may be used to reduce pro-inflammatory cytokine releases that may lead to ALI and/or ARDS.