iodo (1Z)-N-[(5-ethyl-2-oxo-1,3-dihydroindol-3-yl)amino]naphthalene-1-carboximidothioate

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: iodo (1Z)-N-[(5-ethyl-2-oxo-1,3-dihydroindol-3-yl)amino]naphthalene-1-carboximidothioate
• 化学式: C₂₁H₁₈IN₃OS
• 分子量: 487.4
• InChiKey: NOVIFODRAWPGQL-DAFNUICNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  78.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] SPECIFIC INHIBITORS OF PROTEIN P21 AS THERAPEUTIC AGENTS<br/>[FR] INHIBITEURS SPÉCIFIQUES DE LA PROTÉINE P21 COMME AGENTS THÉRAPEUTIQUES
  申请人：BADEN WUERTTEMBERG STIFTUNG GMBH

  公开号：WO2014041125A1

  公开（公告）日：2014-03-20

  The present invention relates to novel inhibitors of p21. These inhibitors are useful as therapeutic agents for promoting cell regeneration and in the treatment of cancer. Improvement of cell regeneration is particularly desirable in patients of old age or in patients suffering from chronic diseases, acute or chronic injuries.