5-[[5-Methyl-2-[3-[2-[[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]amino]-2-oxoethoxy]phenyl]pyrimidin-4-yl]-[(2-methylpropan-2-yl)oxycarbonyl]amino]indazole-1-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 5-[[5-Methyl-2-[3-[2-[[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]amino]-2-oxoethoxy]phenyl]pyrimidin-4-yl]-[(2-methylpropan-2-yl)oxycarbonyl]amino]indazole-1-carboxylic acid
• 英文别名: 5-[[5-methyl-2-[3-[2-[[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]amino]-2-oxoethoxy]phenyl]pyrimidin-4-yl]-[(2-methylpropan-2-yl)oxycarbonyl]amino]indazole-1-carboxylic acid
• 化学式: C₃₆H₄₃N₇O₈
• 分子量: 701.8
• InChiKey: RFXUFWMXEPCUQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  51
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  178
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• RHO KINASE INHIBITORS
  申请人：Kadmon Corporation, LLC

  公开号：EP2903618A2

  公开（公告）日：2015-08-12
• TREATMENT OF OCULAR DISORDERS
  申请人：Kadmon Corporation, LLC

  公开号：EP2903645A2

  公开（公告）日：2015-08-12
• [EN] RHO KINASE INHIBITORS<br/>[FR] INHIBITEURS DE RHO KINASE
  申请人：KADMON CORP LLC

  公开号：WO2014055996A2

  公开（公告）日：2014-04-10

  The invention relates to inhibitors of ROCKl and/or ROCK2. Also provided are methods of treating diseases and disorders involving inhibiting ROCKl and/or ROCK2.
• [EN] TREATMENT OF OCULAR DISORDERS<br/>[FR] TRAITEMENT DE TROUBLES OCULAIRES
  申请人：KADMON CORP LLC

  公开号：WO2014055999A2

  公开（公告）日：2014-04-10

  The invention provides methods of treatment of ocular disorders, including ocular disease with an angiogenic component. In certain embodiments, the treatment comprises administration of a ROCK2 inhibitor and an angiogenesis inhibitor. In certain embodiments, the ROCK2 inhibitor is ROCK2 selective. In certain embodiments, the angiogenesis inhibitor is a VEGF antagonist, for example, and VEGFR2 antibody.