(4aS,4bR,10aR,10bS,12aS)-10a,12a-dimethyl-4,4a,4b,5,6,10b,11,12-octahydro-3H-naphtho[2,1-f]chromene-2,8-dione;4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: (4aS,4bR,10aR,10bS,12aS)-10a,12a-dimethyl-4,4a,4b,5,6,10b,11,12-octahydro-3H-naphtho[2,1-f]chromene-2,8-dione;4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
• 化学式: C33H37N3O3
• 分子量: 523.7
• InChiKey: KYIPPXYJMMTBEP-YYIYBXERSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.27
• 重原子数：
  39
• 可旋转键数：
  1
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  85
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• COMPOSITIONS AND METHODS FOR TREATING MAMMARY TUMORS
  申请人：GEORGETOWN UNIVERSITY

  公开号：US20150265590A1

  公开（公告）日：2015-09-24

  The present invention provides methods of inhibiting abnormal growth of cells, with the methods comprising contacting the cells with at least one of the sensitizing compounds disclosed herein in an amount sufficient to inhibit cell growth. The present invention also provides methods of treating and/or reducing the likelihood of being diagnosed with breast cancer, with the methods comprising administering to a subject in need of treatment thereof at least one of the sensitizing compounds disclosed herein.
• US9603844B2
  申请人：——

  公开号：US9603844B2

  公开（公告）日：2017-03-28
• [EN] COMPOSITIONS AND METHODS FOR TREATING MAMMARY TUMORS<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE TUMEURS MAMMAIRES
  申请人：UNIV GEORGETOWN

  公开号：WO2014066330A1

  公开（公告）日：2014-05-01

  The present invention provides methods of inhibiting abnormal growth of cells, with the methods comprising contacting the cells with at least one of the sensitizing compounds disclosed herein in an amount sufficient to inhibit cell growth. The present invention also provides methods of treating and/or reducing the likelihood of being diagnosed with breast cancer, with the methods comprising administering to a subject in need of treatment thereof at least one of the sensitizing compounds disclosed herein.